Skip to main content
Disciplines
Automotive Business IT + Informatics Construction + Real Estate Electrical Engineering + Electronics Energy + Sustainability Insurance + Risk Finance + Banking Management + Leadership Marketing + Sales Mechanical Engineering + Materials
Events
DE
EN
Books
Journals
Topic Page
Marketing
Start single access now
Access for companies
EXTENDED SEARCH
Log in
Top
Published in:
Concentration-Encoded Molecular Communication in Nanonetworks. Part 1: Fundamentals, Issues, and Challenges Read chapter Read first chapter

2017 | OriginalPaper | Chapter

Communication of Drug Loaded Nanogels with Cancer Cell Receptors for Targeted Delivery

Authors : Govind Soni, Khushwant S. Yadav

Published in: Modeling, Methodologies and Tools for Molecular and Nano-scale Communications

Publisher: Springer International Publishing

Log in

Activate our intelligent search to find suitable subject content or patents.

search-config
loading …

Abstract

The human body is a massive nanoscale molecular communications network composed of billions of interacting cells Drug delivery is an important application of molecular communication. Nanogels are aqueous dispersions of nanoscale size formed by cross-linking of hydrophilic polymers, capable of retaining large amounts of water yet remaining insoluble and maintaining a three-dimensional structure. Nanogel structure enables easy attachment of vector groups for effective communication with cells to reach the desired targeted site. This chapter highlights communication of drug loaded nanogels for targeting cancer through receptors. The chapter critically discusses receptors like- integrin αvβ3, EphA2, folate, Hyaluronan and monoclonal antibody for communication with nanogels.

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

inform now

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

inform now

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 340 Zeitschriften

aus folgenden Fachgebieten:

  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Versicherung + Risiko




Jetzt Wissensvorsprung sichern!

inform now
previous chapter Electromagnetic Nanonetworks for Sensing and Drug Delivery
next chapter Modeling, Analysis and Design of Bio-hybrid Micro-robotic Swarms for Medical Applications
Literature
1.
Aasheim HC, Delabie J, Finne EF (2005) Ephrin-A1 binding to CD4 + T lymphocytes stimulates migration and induces tyrosine phosphorylation of PYK2. Blood 105:2869–2870CrossRef
2.
Akyildiz IF, Brunetti F, Blazquez C (2008) Nanonetworks: a new communication paradigm. Comput Netw 52:2260–2279CrossRef
3.
Atakan B, Akan OB (2010) Deterministic capacity of information flow in molecular nanonetworks. Nano Commun Netw J 1:31–42CrossRef
4.
Ayame H, Morimoto N, Akioshi K (2008) Self-assembled cationic nanogels for intracellular protein delivery. Bioconjugate Chem 19:882–890CrossRef
5.
Blanco MD, Guerrero S, Benito M, Fernández A, Teijón C, Olmo R, Katime I, Teijón JM (2011) In vitro and in vivo evaluation of a folate-targeted copolymeric submicrohydrogel based on n-isopropylacrylamide as 5-Fluorouracil delivery. Polymers 3:1107–1125CrossRef
6.
Brown JM, Giaccia AJ (1998) The unique physiology of solid tumors: opportunities (and problems) for cancer therapy. Cancer Res 58(7):1408–1416
7.
Choi JH, Jang JY, Joung YK, Kwon MH, Park KD (2010) Intracellular delivery and anti-cancer effect of self-assembled heparin-Pluronic nanogels with RNase A. J Control Release 147:420–427CrossRef
8.
Dickerson EB, Blackburn WH, Smith MH, Kapa LB, Lyon LA, McDonald JF (2010) Chemosensitization of cancer cells by siRNA using targeted nanogel delivery. BMC Cancer 10:10CrossRef
9.
Duxbury MS, Ito H, Zinner MJ, Ashley SW, Whang EE (2004) EphA2: a determinant of malignant cellular behavior and a potential therapeutic target in pancreatic adenocarcinoma. Oncogene 23:1448–1456CrossRef
10.
Ghosh SC, Neslihan Alpay S, Klostergaard J (2012) CD44: a validated target for improved delivery of cancer therapeutics. Expert Opin Ther Targets 16(7):635–650CrossRef
11.
Hilgenbrink AR, Low PS (2005) Folate receptor-mediated drug targeting: from therapeutics to diagnostics. J Pharm Sci 94:2135–2146CrossRef
12.
Huang SJ, Sun SL, Feng TH, Sung KH, Lui WL, Wang LF (2009) Folate-mediated chondroitin sulfate-Pluronic® 127 nanogels as a drug carrier. Eur J Pharm Sci 38:64–73CrossRef
13.
Ireton RC, Chen J (2005) EphA2 Receptor Tyrosine Kinase as a Promising Target for Cancer Therapeutics. Curr Cancer Drug Targets 5:149–157CrossRef
14.
Lee ES, Kim D, Youn YS, Oh KT, Bae YH (2008) A virus mimetic nanogel vehicle. Angew Chem 2008; 120(13): 2452–2455
15.
Li N, Wang J, Yang X, Li L (2011) Novel nanogels as drug delivery systems for poorly soluble anticancer drugs. Colloids Surf B 83:237–244CrossRef
16.
Low PS, Kularatne SA (2009) Folate-targeted therapeutic and imaging agents for cancer. Curr Opin Chem Biol 13:256–262CrossRef
17.
Malak D, Akan OB (2012) Molecular communication nanonetworks inside human body. Nano Commun Netw 3:19–35CrossRef
18.
Melero I, Hervas-Stubbs S, Glennie M, Pardoll DM, Chen L (2007) Immunostimulatory monoclonal antibodies for cancer therapy. Nat Rev Cancer 7(2):95–106CrossRef
19.
Misra S, Heldin P, Hascall VC, Karamanos NK, Skandalis SS, Markwald RR, Ghatak S (2011) Hyaluronan–CD44 interactions as potential targets for cancer therapy. FEBS J 278(9):1429–1443CrossRef
20.
Murphy EA, Majeti BK, Mukthavaram R, Acevedo LM, Barnes LA, Cheresh DA (2011) Targeted nanogels: a versatile platform for drug delivery to tumors. Mol Cancer Ther 10(6):972–982CrossRef
21.
Nakano T, Moore M (2011) Molecular communication paradigm overview. J Next Gener Inf Technolo 2(1):9–16CrossRef
22.
Nakano T, Moore MJ, Wei Fang, Vasilakos AV, Shuai Jianwei (2012) Molecular communication and networking: opportunities and challenges. IEEE Trans Nanobiosci 11(2):135–148CrossRef
23.
Nayak S, Lee H, Chmielewski J, Lyon LA (2004) Folate-mediated cell targeting and cytotoxicity using thermoresponsive microgels. J Am Chem Soc 126(33):10258–10259CrossRef
24.
Nukolova NV, Oberoi HS, Cohen SM, Kabanov AV, Bronich TK (2011) Folate-decorated nanogels for targeted therapy of ovarian cancer. Biomaterials 32:5417–5426CrossRef
25.
Nukolova NV, Yang Z, Kim JO, Kabanov AV, Bronich TK (2011) Polyelectrolyte nanogels decorated with monoclonal antibody for targeted drug delivery. React Funct Polym 71:315–323CrossRef
26.
Panyam J, Williams D, Dash A, Leslie-Pelecky D, Labhasetwar V (2004) Solid-state solubility influences encapsulation and release of hydrophobic drugs from PLGA/PLA nanoparticles. J Pharm Sci 93(7):1804–1814CrossRef
27.
Park W, Kim K, Bae B, Kim Y, Na K (2010) Cancer cell specific targeting of nanogels from acetylated hyaluronic acid with low molecular weight. Eur J Pharm Sci 40:367–375CrossRef
28.
Platt VM, Szoka FC Jr (2008) Anticancer therapeutics: targeting macromolecules and nanocarriers to hyaluronan or CD44, a hyaluronan receptor. Mol Pharm 5(4):474–486CrossRef
29.
Raemdonck K, Demeester J, De Smedt S (2009) Advanced nanogel engineering for drug delivery. Soft Matter 5:707–715CrossRef
30.
Scott AM, Wolchok JD, Old LJ (2012) Antibody therapy of cancer. Nat Rev Cancer 12(4):278–287CrossRef
31.
Soni G, Yadav KS (2014) High encapsulation efficiency of poloxamer based injectable thermoresponsive hydrogels of etoposide. Pharm Dev Technol 19(6):651–661CrossRef
32.
33.
Sunderland CJ, Steiert M, Talmadge JE, Derfus AM, Barry SE (2006) Targeted nanoparticles for detecting and treating cancer. Drug Dev Res 67(1):70–93CrossRef
34.
Toole BP (2004) Hyaluronan: from extracellular glue to pericellular cue. Nat Rev Cancer 4:528–539CrossRef
35.
Toole BP (2009) Hyaluronan–CD44 interactions in cancer: paradoxes and possibilities. Clin Cancer Res 15:7462–7468CrossRef
36.
Vinogradov SV, Batrakova EV, Kabanov AV (2004) Nanogels for oligonucleotide delivery to the brain. Bioconjug. Chem. 15:50–60CrossRef
37.
Vinogradov SV, Zeman AD, Batrakova EV, Kabanov AV (2005) Polyplex nanogel formulations for drug delivery of cytotoxic nucleoside analogs. J Control Release 107:143–157CrossRef
38.
Wei X, Senanayake TH, Warren G, Vinogradov SV (2013) Hyaluronic acid-based nanogel-drug conjugates with enhanced anticancer activity designed for the targeting of CD44-positive and drug-resistant tumors. Bioconjugate Chem. 24(4):658–668CrossRef
39.
Wu W, Shen J, Banerjee P, Zhou S (2010) Core shell hybrid nanogels for integration of optical temperature-sensing, targeted tumor cell imaging, and combined chemo-photothermal treatment. Biomaterials 31:7555–7566CrossRef
40.
Yadav KS, Jacob S, Sachdeva G, Chuttani K, Mishra AK, Sawant KK (2011) Long circulating PEGylated PLGA nanoparticles of cytarabine for targeting leukemia. J Microencapsul 28(8):729–742CrossRef
41.
Yoo HS, Park TG (2004) Folate receptor targeted biodegradable polymeric doxorubicin micelles. J Control Release 96:273–283CrossRef
Metadata
Title
Communication of Drug Loaded Nanogels with Cancer Cell Receptors for Targeted Delivery
Authors
Govind Soni
Khushwant S. Yadav
Copyright Year
2017
Book
Modeling, Methodologies and Tools for Molecular and Nano-scale Communications

Print ISBN: 978-3-319-50686-9

Electronic ISBN: 978-3-319-50688-3

Copyright Year: 2017

DOI
https://doi.org/10.1007/978-3-319-50688-3_21