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Journal of Nanoparticle Research
Published in: Journal of Nanoparticle Research 1/2015

01-01-2015 | Research Paper

Comparative study of aluminum phthalocyanine incorporating into two types of block copolymer: photo-physical property, size, and in vitro photodynamic therapy efficacy

Authors: Yide Huang, Dongdong Ma, Sujuan Pan, Pingping Lin, Yao Lin, Hongqin Yang, Yiru Peng

Published in: Journal of Nanoparticle Research | Issue 1/2015

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Abstract

Nanoparticles of amphiphilic triblock copolymer poly(l-lysine)-b-poly(ethylene glycol)-b-poly(l-lysine) and diblock copolymer methoxy-poly(ethylene glycol)-b-poly(l-lysine) were developed to encapsulate tetra(4-sulfoazophenyl-4′-aminosulfonyl) chloride aluminum phthalocyanine, a new photosensitizer used in photodynamic therapy. The mean nanoparticle sizes varied from 10 to 70 nm, and the encapsulation efficacy ranged from 56 to 73 % due to electrostatic self-assembly induced by two types of polymer. The characteristic photophysical parameters including the absorption spectrum profile, fluorescence quantum yield, and fluorescence decay curves for free and encapsulated phthalocyanine were analyzed. The cellular uptake amount and photoactivity of S-AlPc were improved by encapsulation. The aluminum phthalocyanine loaded with poly(l-lysine)-b-poly(ethylene glycol)-b-poly(l-lysine) presented suitable physical stability, improved photophysical properties, and enhanced phototoxicity in vitro, suggesting it may be considered as a promising formulation for PDT.
previous article Design, formulation, in vitro, in vivo, and pharmacokinetic evaluation of nisoldipine-loaded self-nanoemulsifying drug delivery system
next article Silver nanoparticle colloids with γ-cyclodextrin: enhanced stability and Gibbs–Marangoni flow

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Metadata
Title
Comparative study of aluminum phthalocyanine incorporating into two types of block copolymer: photo-physical property, size, and in vitro photodynamic therapy efficacy
Authors
Yide Huang
Dongdong Ma
Sujuan Pan
Pingping Lin
Yao Lin
Hongqin Yang
Yiru Peng
Publication date
01-01-2015
Publisher
Springer Netherlands
Published in
Journal of Nanoparticle Research / Issue 1/2015
Print ISSN: 1388-0764
Electronic ISSN: 1572-896X
DOI
https://doi.org/10.1007/s11051-014-2819-y

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