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Arabian Journal for Science and Engineering
Published in: Arabian Journal for Science and Engineering 1/2020

26-09-2019 | Research Article - Biological Sciences

Comparative Study of Biological (Phoenix loureiroi Fruit) and Chemical Synthesis of Chitosan-Encapsulated Zinc Oxide Nanoparticles and their Biological Properties

Authors: Murugan Rajan, Allen Joseph Anthuvan, Kasipandi Muniyandi, Naveen Kumar Kalagatur, Saravanan Shanmugam, Saikumar Sathyanarayanan, Viswanathan Chinnuswamy, Parimelazhagan Thangaraj, Narendra Narain

Published in: Arabian Journal for Science and Engineering | Issue 1/2020

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Abstract

In the present study, the effect of in vitro antioxidant and cytotoxic properties was investigated in the biologically and chemically synthesized zinc oxide (ZnO)- and chitosan (CTS)-encapsulated ZnO (ZnO–CTS) nanoparticles. The nanoparticles were biologically synthesized using Phoenix loureiroi fruit and characterized using Fourier transform infrared, X-ray diffraction, scanning electron microscopy, field emission scanning transmission electron microscopy, energy-dispersive X-ray spectroscopy and ultra violet-diffuse reflectance spectroscopy. The biologically synthesized ZnO–CTS nanoparticles (B-ZnO–CTS) results revealed good chemical structure (H–N–H, O–H, C=O, Zn and O groups), crystalline size (18 nm), morphology (spherical), elemental composition (Zn = 61.10%; O = 25.86%; C = 13.04%) and optical properties (λ = 374 nm; Eg = 3.18 eV). The B-ZnO–CTS also exhibited higher DPPH· (IC50 = 419.32 µg/mL), ABTS·+ (45.61%), nitric oxide (21.28%), hydroxyl radical (77.10%) scavenging activities and superoxide anion radical production (27.89%). The cytotoxicity of B-ZnO–CTS revealed less hemolytic property (2.17%) and inhibited the Caco-2 cancerous cell viability (IC50 = 70.45 µg/mL). In conclusion, biological synthesis presents better prospects in pharmacotherapeutic applications in nano-herbal drug delivery.
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Metadata
Title
Comparative Study of Biological (Phoenix loureiroi Fruit) and Chemical Synthesis of Chitosan-Encapsulated Zinc Oxide Nanoparticles and their Biological Properties
Authors
Murugan Rajan
Allen Joseph Anthuvan
Kasipandi Muniyandi
Naveen Kumar Kalagatur
Saravanan Shanmugam
Saikumar Sathyanarayanan
Viswanathan Chinnuswamy
Parimelazhagan Thangaraj
Narendra Narain
Publication date
26-09-2019
Publisher
Springer Berlin Heidelberg
Published in
Arabian Journal for Science and Engineering / Issue 1/2020
Print ISSN: 2193-567X
Electronic ISSN: 2191-4281
DOI
https://doi.org/10.1007/s13369-019-04174-1

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