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2012 | OriginalPaper | Chapter

Computational Models as Novel Tools for Cancer Vaccines

Authors: Filippo Castiglione, Pier Luigi Lollini, Santo Motta, Arianna Paladini, Francesco Pappalardo, Marzio Pennisi

Published in: New Challenges for Cancer Systems Biomedicine

Publisher: Springer Milan

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Abstract

Prevention of tumor growth by immunological approaches is based on the assumption that the immune system, if adequately stimulated before tumor onset, could be able to protect from specific cancers. In the last decade active immunization strategies effectively prevented some virus-related cancers in humans. An immunopreventive cell vaccine for the non-virus-related human breast cancer has been recently developed. This vaccine, called Triplex, targets the HER-2-neu oncogene in HER-2/neu transgenic mice and has shown to almost completely prevent HER-2/neu-driven mammary carcinogenesis when administered with an intensive and life-long schedule. To better understand the preventive efficacy of the Triplex vaccine in reduced schedules we employed a computational approach. The computer model developed allowed us to test specific vaccination schedules in the quest for optimality. Furthermore, another computational model was developed to simulate the scenario arising from the immunotherapy experiments with the Triplex vaccine as a therapeutic approach against lung metastases derived by mammary carcinoma. This chapter describes the trail we followed starting from the problem of evaluating immunopreventive schedules with a generic computer model for the immune system response to a model of metastasis passing through an in-silico detailed model of the cancer-immune system interaction in HER-2/neu transgenic mice. Altogether it provides an example of the successful use of a combination of animal and computational modeling to speed up the way from lab to the bedside and even the patient.

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Literature
1.
go back to reference Abbas, A.K., Lichtman, A.H., Pillai, S.: Cellular and Molecular Immunology, 6th edn. Elsevier, Philadelphia (2007) Abbas, A.K., Lichtman, A.H., Pillai, S.: Cellular and Molecular Immunology, 6th edn. Elsevier, Philadelphia (2007)
2.
go back to reference Bernaschi, M., Castiglione, F.: Design and implementation of an immune system simulator. Comp. Biol. Med. 31( 5), 303–331 (2001) CrossRef Bernaschi, M., Castiglione, F.: Design and implementation of an immune system simulator. Comp. Biol. Med. 31( 5), 303–331 (2001) CrossRef
3.
go back to reference Boggio, K., Nicoletti, G., Di Carlo, E., Cavallo, F., Landuzzi, L., Melani, C., Giovarelli, M., Rossi, I., Nanni, P., De Giovanni, C., Bouchard, P., Wolf, S., Modesti, A., Musiani, P., Lollini, P.L., Colombo, M.P., Forni, G.: Interleukin 12-mediated prevention of spontaneous mammary adenocarcinomas in two lines of Her-2/neu transgenic mice. J. Exp. Med. 188, 589–596 (1998) CrossRef Boggio, K., Nicoletti, G., Di Carlo, E., Cavallo, F., Landuzzi, L., Melani, C., Giovarelli, M., Rossi, I., Nanni, P., De Giovanni, C., Bouchard, P., Wolf, S., Modesti, A., Musiani, P., Lollini, P.L., Colombo, M.P., Forni, G.: Interleukin 12-mediated prevention of spontaneous mammary adenocarcinomas in two lines of Her-2/neu transgenic mice. J. Exp. Med. 188, 589–596 (1998) CrossRef
4.
go back to reference Brenner, S., Milstein, C.: Origin of antibody variation. Nature 211, 242–243 (1966) CrossRef Brenner, S., Milstein, C.: Origin of antibody variation. Nature 211, 242–243 (1966) CrossRef
5.
go back to reference Burnet, F.M.: The Clonal Selection Theory of Acquired Immunity. Vanderbilt University, Nashville, TN (1959) CrossRef Burnet, F.M.: The Clonal Selection Theory of Acquired Immunity. Vanderbilt University, Nashville, TN (1959) CrossRef
6.
go back to reference Castiglione, F.: Agent Based Modeling. Scholarpedia 1(10), 1562 (2006) Castiglione, F.: Agent Based Modeling. Scholarpedia 1(10), 1562 (2006)
7.
go back to reference Castiglione, F.: Agent Based Modeling and Simulation, Introduction to. In: Meyers, R. (ed.) Encyclopedia of Complexity and Systems Science, vol 1, pp. 197–200. Springer, New York (2009) CrossRef Castiglione, F.: Agent Based Modeling and Simulation, Introduction to. In: Meyers, R. (ed.) Encyclopedia of Complexity and Systems Science, vol 1, pp. 197–200. Springer, New York (2009) CrossRef
8.
go back to reference Castiglione, F., Duca, K.A., Jarrah, A., Laubenbacher, R., Luzuriaga, K., Hochberg, D., Thorley-Lawson, D.A.. Simulating Epstein Barr Virus Infection with C-ImmSim. Bioinfor- matics 23, 1371–1377 (2007) CrossRef Castiglione, F., Duca, K.A., Jarrah, A., Laubenbacher, R., Luzuriaga, K., Hochberg, D., Thorley-Lawson, D.A.. Simulating Epstein Barr Virus Infection with C-ImmSim. Bioinfor- matics 23, 1371–1377 (2007) CrossRef
9.
go back to reference Castiglione, F., Poccia, F., D’Offizi, G., Bernaschi, M.: Mutation, fitness, viral diversity, and predictive markers of disease progression in a computational model of HIV type 1 infection. AIDS Res. Hum. Retrovirus 20(12), 1314–1323 (2004) CrossRef Castiglione, F., Poccia, F., D’Offizi, G., Bernaschi, M.: Mutation, fitness, viral diversity, and predictive markers of disease progression in a computational model of HIV type 1 infection. AIDS Res. Hum. Retrovirus 20(12), 1314–1323 (2004) CrossRef
10.
go back to reference Castiglione, F., Santoni, D., Rapin, N.: CTLs’ repertoire shaping in the thymus: a Montecarlo simulation. Autoimmunity 44(4), 1–10 (2011) CrossRef Castiglione, F., Santoni, D., Rapin, N.: CTLs’ repertoire shaping in the thymus: a Montecarlo simulation. Autoimmunity 44(4), 1–10 (2011) CrossRef
11.
go back to reference Cavallo, F., Calogero, R.A., Forni, G.: Are oncoantigens suitable targets for anti-tumour therapy? Nat. Rev. Cancer 7, 707–713 (2007) CrossRef Cavallo, F., Calogero, R.A., Forni, G.: Are oncoantigens suitable targets for anti-tumour therapy? Nat. Rev. Cancer 7, 707–713 (2007) CrossRef
12.
go back to reference Cavallo, F., De Giovanni, C., Nanni, P., Forni, G., Lollini, P-L.: The immune hallmarks of cancer. Cancer Immunol. Immunother. 60, 319–326 (2011) CrossRef Cavallo, F., De Giovanni, C., Nanni, P., Forni, G., Lollini, P-L.: The immune hallmarks of cancer. Cancer Immunol. Immunother. 60, 319–326 (2011) CrossRef
13.
go back to reference De Giovanni, C., Nicoletti, G., Landuzzi, L., Astolfi, A., Croci, S., Comes, A., Ferrini, S., Meazza, R., Iezzi, M., Di Carlo, E., Musiani, P., Cavallo, F., Nanni, P., Lollini, P.L.: Immunoprevention of HER-2/neu transgenic mammary carcinoma through an interleukin 12- engineered allogeneic cell vaccine. Cancer Res. 64, 4001–4009 (2004) CrossRef De Giovanni, C., Nicoletti, G., Landuzzi, L., Astolfi, A., Croci, S., Comes, A., Ferrini, S., Meazza, R., Iezzi, M., Di Carlo, E., Musiani, P., Cavallo, F., Nanni, P., Lollini, P.L.: Immunoprevention of HER-2/neu transgenic mammary carcinoma through an interleukin 12- engineered allogeneic cell vaccine. Cancer Res. 64, 4001–4009 (2004) CrossRef
14.
15.
go back to reference Dunn, G.P., Old, L.J., Schreiber, R.D.: The immunobiology of cancer immunosurveillance and immunoediting. Immunity 21, 137–148 (2004) CrossRef Dunn, G.P., Old, L.J., Schreiber, R.D.: The immunobiology of cancer immunosurveillance and immunoediting. Immunity 21, 137–148 (2004) CrossRef
16.
17.
go back to reference Francis, K., Palsson, B.O.: Effective intercellular communication distances are determined by the relative time constants for cyto/chemokine secretion and diffusion. Proc. Natl. Acad. Sci. USA 94(23), 12258–12262(1997) Francis, K., Palsson, B.O.: Effective intercellular communication distances are determined by the relative time constants for cyto/chemokine secretion and diffusion. Proc. Natl. Acad. Sci. USA 94(23), 12258–12262(1997)
18.
go back to reference Hayflick, L., Moorhead, P.S.: The serial cultivation of human diploid cell strains. Exp. Cell. Res. 25, 585–621 (1961) CrossRef Hayflick, L., Moorhead, P.S.: The serial cultivation of human diploid cell strains. Exp. Cell. Res. 25, 585–621 (1961) CrossRef
19.
go back to reference Jerne, N.K.: Towards a network theory of the immune system. Ann. Immunol. 125C, 373–389 (1974) Jerne, N.K.: Towards a network theory of the immune system. Ann. Immunol. 125C, 373–389 (1974)
20.
go back to reference Lederberg, J.: Genes and antibodies. Science 129, 1649–1653 (1959) Lederberg, J.: Genes and antibodies. Science 129, 1649–1653 (1959)
21.
go back to reference Lollini, P.L., Cavallo, F., Nanni, P., Forni, G.: Vaccines for tumor prevention. Nat. Rev. Cancer 6, 204–216 (2006) CrossRef Lollini, P.L., Cavallo, F., Nanni, P., Forni, G.: Vaccines for tumor prevention. Nat. Rev. Cancer 6, 204–216 (2006) CrossRef
22.
go back to reference Lollini, P.L., Motta, S., Pappalardo, F.: Discovery of cancer vaccination protocols with a genetic algorithm driving an agent based simulator. BMC Bioinformatics 7, 352 (2006) CrossRef Lollini, P.L., Motta, S., Pappalardo, F.: Discovery of cancer vaccination protocols with a genetic algorithm driving an agent based simulator. BMC Bioinformatics 7, 352 (2006) CrossRef
23.
go back to reference Lollini, P.L., Motta, S., Pappalardo, F.: Modeling tumor immunology, Mathematical Models & Methods in Applied Sciences 16(7S), 1091–1124 (2006) CrossRefMATHMathSciNet Lollini, P.L., Motta, S., Pappalardo, F.: Modeling tumor immunology, Mathematical Models & Methods in Applied Sciences 16(7S), 1091–1124 (2006) CrossRefMATHMathSciNet
24.
go back to reference Lollini, P.L., Nicoletti, G., Landuzzi, L., Cavallo, F., Forni, G., De Giovanni, C., Nanni, P.: Vaccines and other immunological approaches for cancer immunoprevention. Curr. Drug. Targets 12, 1957–1973 (2010) CrossRef Lollini, P.L., Nicoletti, G., Landuzzi, L., Cavallo, F., Forni, G., De Giovanni, C., Nanni, P.: Vaccines and other immunological approaches for cancer immunoprevention. Curr. Drug. Targets 12, 1957–1973 (2010) CrossRef
25.
go back to reference Matzinger, P.: Tolerance, Danger, and the Extended Family. Ann. Rev. Immunol. 12, 991–1045(1994) CrossRef Matzinger, P.: Tolerance, Danger, and the Extended Family. Ann. Rev. Immunol. 12, 991–1045(1994) CrossRef
26.
go back to reference Murphy, K., Travers, P., Janeway, C., Walport, M.: Janeway’s Immunology. Garland Science, Taylor and Francis, New York (2008) Murphy, K., Travers, P., Janeway, C., Walport, M.: Janeway’s Immunology. Garland Science, Taylor and Francis, New York (2008)
27.
go back to reference Nanni, P., Landuzzi, L., Nicoletti, G., De Giovanni, C., Rossi, I., Croci, S., Astolfi, A., Iezzi, M., Di Carlo, E., Musiani, P., Forni, G., Lollini, P.L.: Immunoprevention of mammary carcinoma in HER-2/neu transgenic mice is IFN-gamma and B cell dependent. J. Immunol. 173, 2288 –2296 (2004) CrossRef Nanni, P., Landuzzi, L., Nicoletti, G., De Giovanni, C., Rossi, I., Croci, S., Astolfi, A., Iezzi, M., Di Carlo, E., Musiani, P., Forni, G., Lollini, P.L.: Immunoprevention of mammary carcinoma in HER-2/neu transgenic mice is IFN-gamma and B cell dependent. J. Immunol. 173, 2288 2296 (2004) CrossRef
28.
go back to reference Nanni, P., Nicoletti, G., De Giovanni, C., Landuzzi, L., Di Carlo, E., Cavallo, F., Pupa, S.M., Rossi, I., Colombo, M.P., Ricci, C., Astolfi, A., Musiani, P., Forni, G., Lollini, P.L.: Combined allogeneic tumor cell vaccination and systemic interleukin 12 prevents mammary carcinogen- esis in HER-2/neu transgenic mice. J. Exp. Med. 194, 1195–1205 (2001) CrossRef Nanni, P., Nicoletti, G., De Giovanni, C., Landuzzi, L., Di Carlo, E., Cavallo, F., Pupa, S.M., Rossi, I., Colombo, M.P., Ricci, C., Astolfi, A., Musiani, P., Forni, G., Lollini, P.L.: Combined allogeneic tumor cell vaccination and systemic interleukin 12 prevents mammary carcinogen- esis in HER-2/neu transgenic mice. J. Exp. Med. 194, 1195–1205 (2001) CrossRef
29.
go back to reference Nanni, P., Nicoletti, G., Palladini, A., Croci, S., Murgo, A., Antognoli, A., Landuzzi, L., Fabbi, M., Ferrini, S., Musiani, P., Iezzi, M., De Giovanni, C., Lollini, P.L.: Antimetastatic activity of a preventive cancer vaccine. Cancer Res. 67, 11037–11044 (2007) CrossRef Nanni, P., Nicoletti, G., Palladini, A., Croci, S., Murgo, A., Antognoli, A., Landuzzi, L., Fabbi, M., Ferrini, S., Musiani, P., Iezzi, M., De Giovanni, C., Lollini, P.L.: Antimetastatic activity of a preventive cancer vaccine. Cancer Res. 67, 11037–11044 (2007) CrossRef
30.
go back to reference Novellino, L., Castelli, C., Parmiani, G.: A listing of human tumor antigens recognized by T cells. Cancer Immunol. Immunother. 54, 187–207 (2005) CrossRef Novellino, L., Castelli, C., Parmiani, G.: A listing of human tumor antigens recognized by T cells. Cancer Immunol. Immunother. 54, 187–207 (2005) CrossRef
31.
go back to reference Nossal, G.J.V., Pike Beverley, L.: Clonal anergy: Persistence in tolerant mice of antigen- binding B lymphocytes incapable of responding to antigen or mitogen. Proc. Natl. Acad. Sci. USA 77( 3), 1602–1606 (1980) CrossRef Nossal, G.J.V., Pike Beverley, L.: Clonal anergy: Persistence in tolerant mice of antigen- binding B lymphocytes incapable of responding to antigen or mitogen. Proc. Natl. Acad. Sci. USA 77( 3), 1602–1606 (1980) CrossRef
32.
go back to reference Palladini, A., Nicoletti, G., Pappalardo, F., Murgo, A., Grosso, V., Stivani, V., Ianzano, M.L., Antognoli, A., Croci, S., Landuzzi, L., De Giovanni, C., Nanni, P., Motta, S., Lollini, P.L.: In silico modeling and in vivo efficacy of cancer-preventive vaccinations. Cancer Res. 70, 7755–7763(2010) CrossRef Palladini, A., Nicoletti, G., Pappalardo, F., Murgo, A., Grosso, V., Stivani, V., Ianzano, M.L., Antognoli, A., Croci, S., Landuzzi, L., De Giovanni, C., Nanni, P., Motta, S., Lollini, P.L.: In silico modeling and in vivo efficacy of cancer-preventive vaccinations. Cancer Res. 70, 7755–7763(2010) CrossRef
33.
go back to reference Pappalardo, F., Castiglione, F., Lollini, P.L., Motta, S.: Modelling and Simulation of Cancer Immunoprevention Vaccine. Bioinformatics 21(12), 2891–2897 (2005) CrossRef Pappalardo, F., Castiglione, F., Lollini, P.L., Motta, S.: Modelling and Simulation of Cancer Immunoprevention Vaccine. Bioinformatics 21(12), 2891–2897 (2005) CrossRef
34.
go back to reference Pappalardo, F., Mastriani, E., Lollini, P.L., Motta, S.: Genetic Algorithm against Cancer. Lect. Notes Comp. Sci. 3849, 223–228 (2009) CrossRefMATH Pappalardo, F., Mastriani, E., Lollini, P.L., Motta, S.: Genetic Algorithm against Cancer. Lect. Notes Comp. Sci. 3849, 223–228 (2009) CrossRefMATH
35.
go back to reference Pappalardo, F., Pennisi, M., Castiglione, F., Motta, S.: Vaccine protocols optimization: in silico experiences. Biotechnology Advances 28, 82–93 (2010) CrossRef Pappalardo, F., Pennisi, M., Castiglione, F., Motta, S.: Vaccine protocols optimization: in silico experiences. Biotechnology Advances 28, 82–93 (2010) CrossRef
36.
go back to reference Pennisi, M., Catanuto, R., Mastriani, E., Cincotti, A., Pappalardo, F., Motta, S.: Simulated Annealing And Optimal Protocols. J. Circuits Systems and Computers 18(8), 1565–1579 (2009) CrossRef Pennisi, M., Catanuto, R., Mastriani, E., Cincotti, A., Pappalardo, F., Motta, S.: Simulated Annealing And Optimal Protocols. J. Circuits Systems and Computers 18(8), 1565–1579 (2009) CrossRef
37.
go back to reference Pennisi, M., Catanuto, R., Pappalardo, F., Motta, S.: Optimal vaccination schedules using Simulated Annealing, Bioinformatics 24(15), 1740–1742 (2008) CrossRef Pennisi, M., Catanuto, R., Pappalardo, F., Motta, S.: Optimal vaccination schedules using Simulated Annealing, Bioinformatics 24(15), 1740–1742 (2008) CrossRef
38.
go back to reference Pennisi, M., Pappalardo, F., Motta, S.: Agent based modeling of lung metastasis-immune system competition. Lect. Notes Comp Sci 5666, 1–3 (2009) CrossRef Pennisi, M., Pappalardo, F., Motta, S.: Agent based modeling of lung metastasis-immune system competition. Lect. Notes Comp Sci 5666, 1–3 (2009) CrossRef
39.
go back to reference Pennisi, M., Pappalardo, F., Palladini, A., Nicoletti, G., Nanni, P., Lollini, P.L., Motta, S.: Modeling the competition between lung metastases and the immune system using agents. BMC Bioinformatics 11(S7), S13 (2010) CrossRef Pennisi, M., Pappalardo, F., Palladini, A., Nicoletti, G., Nanni, P., Lollini, P.L., Motta, S.: Modeling the competition between lung metastases and the immune system using agents. BMC Bioinformatics 11(S7), S13 (2010) CrossRef
40.
go back to reference Pennisi, M., Pappalardo, F., Zhang, P., Motta, S.: Searching of optimal vaccination schedules: application of genetic algorithms to approach the problem in cancer immunoprevention. IEEE Eng. Med. Biol. Magazine 28(4), 67–72 (2009) CrossRef Pennisi, M., Pappalardo, F., Zhang, P., Motta, S.: Searching of optimal vaccination schedules: application of genetic algorithms to approach the problem in cancer immunoprevention. IEEE Eng. Med. Biol. Magazine 28(4), 67–72 (2009) CrossRef
41.
go back to reference Rapin, N., Lund, O., Bernaschi, M., Castiglione, F.: Computational immunology meets bioin- formatics: the use of prediction tools for molecular binding in the simulation of the immune system. PLoS ONE 5(4), e9862 (2010) CrossRef Rapin, N., Lund, O., Bernaschi, M., Castiglione, F.: Computational immunology meets bioin- formatics: the use of prediction tools for molecular binding in the simulation of the immune system. PLoS ONE 5(4), e9862 (2010) CrossRef
42.
go back to reference Rosenberg, S.A., Yang, J.C., Restifo, N.P.: Cancer immunotherapy: moving beyond current vaccines. Nat. Med. 10, 909–915 (2004) CrossRef Rosenberg, S.A., Yang, J.C., Restifo, N.P.: Cancer immunotherapy: moving beyond current vaccines. Nat. Med. 10, 909–915 (2004) CrossRef
43.
go back to reference Santoni, D., Pedicini, M., Castiglione, F.: Implementation of a regulatory gene network to simulate the TH1/2 differentiation in an agent-based model of hyper-sensitivity reactions. Bioinformatics 24(11), 1374–1380 (2008) CrossRef Santoni, D., Pedicini, M., Castiglione, F.: Implementation of a regulatory gene network to simulate the TH1/2 differentiation in an agent-based model of hyper-sensitivity reactions. Bioinformatics 24(11), 1374–1380 (2008) CrossRef
44.
45.
go back to reference Segovia-Juarez, J.L., Ganguli, S., Kirschner, D.: Identifying control mechanisms of granuloma formation during M. tuberculosis infection using an agent-based model. J. Theo. Biol. 231(3), 357–376 (2004) Segovia-Juarez, J.L., Ganguli, S., Kirschner, D.: Identifying control mechanisms of granuloma formation during M. tuberculosis infection using an agent-based model. J. Theo. Biol. 231(3), 357–376 (2004)
46.
go back to reference Slamon, D.J., Godolphin, W., Jones, L.A., Holt, J.A., Wong, S.G., Keith, D.E., Levin, W.J., Stuart, S.G., Udove, J., Ullrich, A.: Studies of the HER-2/neu protooncogene in human breast and ovarian cancer. Science 244, 707–712 (1989) CrossRef Slamon, D.J., Godolphin, W., Jones, L.A., Holt, J.A., Wong, S.G., Keith, D.E., Levin, W.J., Stuart, S.G., Udove, J., Ullrich, A.: Studies of the HER-2/neu protooncogene in human breast and ovarian cancer. Science 244, 707–712 (1989) CrossRef
47.
go back to reference Ursini-Siegel, J., Schade, B., Cardiff, R.D., Muller, W.J.: Insights from transgenic mouse models of ERBB2-induced breast cancer. Nat. Rev. Cancer 7, 389–397 (2007) CrossRef Ursini-Siegel, J., Schade, B., Cardiff, R.D., Muller, W.J.: Insights from transgenic mouse models of ERBB2-induced breast cancer. Nat. Rev. Cancer 7, 389–397 (2007) CrossRef
48.
go back to reference Wolfram, S.: ANew Kind of Science. Wolfram Media, Champain, Illinois, USA (2002) Wolfram, S.: ANew Kind of Science. Wolfram Media, Champain, Illinois, USA (2002)
49.
go back to reference Zhang, X., Mosser, D.M.: Macrophage activation by endogenous danger signals. J. Pathol. 214, 161–171 (2008) CrossRef Zhang, X., Mosser, D.M.: Macrophage activation by endogenous danger signals. J. Pathol. 214, 161–171 (2008) CrossRef
Metadata
Title
Computational Models as Novel Tools for Cancer Vaccines
Authors
Filippo Castiglione
Pier Luigi Lollini
Santo Motta
Arianna Paladini
Francesco Pappalardo
Marzio Pennisi
Copyright Year
2012
Publisher
Springer Milan
DOI
https://doi.org/10.1007/978-88-470-2571-4_12

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