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01-12-2019 | Original Article | Issue 1/2019

Network Modeling Analysis in Health Informatics and Bioinformatics 1/2019

Computational simulation of inhibitory effects of curcumin, retinoic acid and their conjugates on GSK-3 beta

Journal:
Network Modeling Analysis in Health Informatics and Bioinformatics > Issue 1/2019
Authors:
Hemanshi Mishra, Rajesh Kumar Kesharwani, Dev Bukhsh Singh, Sandeep Tripathi, Shiv Kumar Dubey, Krishna Misra

Abstract

Turmeric, since in ancient Indian traditional medicinal system, has been implicated for its therapeutic and chemopreventive properties against a broad spectrum of diseases. Curcumin, the active polyphenol from turmeric, helps to obstruct the growth of many types of cancers at various stages which include prostrate, melanoma, breast, brain tumor, pancreatic, leukemia, etc. The initiation and recurrence of cancer have been attributed to few mutated cells in bulk of tumor called as cancer stem cells which have the capacity of self-renewal and differentiation. Glycogen synthase kinase-3 beta (GSK-3B) is a multifunctional serine/threonine protein kinase, originally found in mammals, an important component of diverse signaling pathways, dysregulation of which leads to affect the cancer stem cell properties. The nutritional- and phytochemical-based dietary interventions may complement current chemotherapy to prevent recurrence and relapse of cancer. The objective of present study is to investigate the effect of retinoic acid and curcumin–retinoic acid conjugates against GSK-3B protein. The in silico results indicate that molecule 3 (curcumin–retinoic acid conjugates) might be a potent inhibitor of GSK-3B and a novel future drug candidate for the treatment of cancer.

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