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2017 | OriginalPaper | Chapter

11. Controlled Molecular Assembly Toward Self-propelled Micro-/Nanomotors

Authors : Xiankun Lin, Zhiguang Wu, Qiang He

Published in: Supramolecular Chemistry of Biomimetic Systems

Publisher: Springer Singapore

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Abstract

Micro-/nanomotors (MNMs) are able to propel themselves in fluids through converting different energies from environment into kinetic energy. Recently, layer-by-layer (LbL) assembly, a versatile assembly approach, has been employed to access MNMs with advantages such as regulated motion, stimuli-response properties, and multifunctionality. In this chapter, we review the recent progress on controlled fabrication, motion control, and biomedical applications of MNMs based on controlled molecular assembly. Through integrating diverse functional building blocks such as nanoparticles, enzymes, and metal shells, MNMs with various structures (e.g., hollow capsules and nanotubes) have been prepared, and the control over the on/off state of the MNM motion has been realized. In addition, we also discuss a special type of MNMs which is derived from the combination of as-assembled biological aggregates and artificial nanostructures. These MNMs can be driven by bubble recoil, irradiation by near-infrared light, and ultrasonic fields. We have also demonstrated the potential applications of these assembled MNMs in biomedical fields such as targeted drug delivery, photothermal therapy, and detoxification.

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Literature
1.
go back to reference Li JB, He Q, Yan XH (2011) Molecular assembly of biomimetic systems. Wiley-VCH, Weinheim Li JB, He Q, Yan XH (2011) Molecular assembly of biomimetic systems. Wiley-VCH, Weinheim
8.
go back to reference Wang J (2013) Nanomachines: fundamentals and applications. Wiley-VCH, WeinheimCrossRef Wang J (2013) Nanomachines: fundamentals and applications. Wiley-VCH, WeinheimCrossRef
15.
go back to reference Balasubramanian S, Kagan D, Hu C-MJ, Campuzano S, Lobo-Castañon MJ, Lim N, Kang DY, Zimmerman M, Zhang LF, Wang J (2011) Micromachine-enabled capture and isolation of cancer cells in complex media. Angew Chem Int Ed 50(18):4161–4164. doi:10.1002/anie.201100115 CrossRef Balasubramanian S, Kagan D, Hu C-MJ, Campuzano S, Lobo-Castañon MJ, Lim N, Kang DY, Zimmerman M, Zhang LF, Wang J (2011) Micromachine-enabled capture and isolation of cancer cells in complex media. Angew Chem Int Ed 50(18):4161–4164. doi:10.​1002/​anie.​201100115 CrossRef
17.
21.
go back to reference Paxton WF, Kistler KC, Olmeda CC, Sen A, St. Angelo SK, Cao Y, Mallouk TE, Lammert PE, Crespi VH (2004) Catalytic nanomotors:  autonomous movement of striped nanorods. J Am Chem Soc 126(41):13424–13431. doi:10.1021/ja047697z Paxton WF, Kistler KC, Olmeda CC, Sen A, St. Angelo SK, Cao Y, Mallouk TE, Lammert PE, Crespi VH (2004) Catalytic nanomotors:  autonomous movement of striped nanorods. J Am Chem Soc 126(41):13424–13431. doi:10.​1021/​ja047697z
30.
36.
37.
go back to reference Wu YJ, Lin XK, Wu ZG, Möhwald H, He Q (2014) Self-propelled polymer multilayer janus capsules for effective drug delivery and light-triggered release. ACS Appl Mater Interfaces 6(13):10476–10481. doi:10.1021/am502458h CrossRef Wu YJ, Lin XK, Wu ZG, Möhwald H, He Q (2014) Self-propelled polymer multilayer janus capsules for effective drug delivery and light-triggered release. ACS Appl Mater Interfaces 6(13):10476–10481. doi:10.​1021/​am502458h CrossRef
38.
go back to reference del Mercato LL, Carraro M, Zizzari A, Bianco M, Miglietta R, Arima V, Viola I, Nobile C, Soraru A, Vilona D, Gigli G, Bonchio M, Rinaldi R (2014) Catalytic self-propulsion of supramolecular capsules powered by polyoxometalate cargos. Chem Eur J 20(35):10910–10914. doi:10.1002/chem.201403171 CrossRef del Mercato LL, Carraro M, Zizzari A, Bianco M, Miglietta R, Arima V, Viola I, Nobile C, Soraru A, Vilona D, Gigli G, Bonchio M, Rinaldi R (2014) Catalytic self-propulsion of supramolecular capsules powered by polyoxometalate cargos. Chem Eur J 20(35):10910–10914. doi:10.​1002/​chem.​201403171 CrossRef
41.
go back to reference Wu ZG, Wu YJ, He WP, Lin XK, Sun JM, He Q (2013) Self-propelled polymer-based multilayer nanorockets for transportation and drug release. Angew Chem Int Ed 52(27):7000–7003. doi:10.1002/anie.201301643 CrossRef Wu ZG, Wu YJ, He WP, Lin XK, Sun JM, He Q (2013) Self-propelled polymer-based multilayer nanorockets for transportation and drug release. Angew Chem Int Ed 52(27):7000–7003. doi:10.​1002/​anie.​201301643 CrossRef
43.
go back to reference Gai MY, Frueh J, Hu N, Si TY, Sukhorukov GB, He Q (2016) Self-propelled two dimensional polymer multilayer plate micromotors. Phys Chem Chem Phys 18(5):3397–3401. doi:10.1039/c5cp07697h CrossRef Gai MY, Frueh J, Hu N, Si TY, Sukhorukov GB, He Q (2016) Self-propelled two dimensional polymer multilayer plate micromotors. Phys Chem Chem Phys 18(5):3397–3401. doi:10.​1039/​c5cp07697h CrossRef
46.
go back to reference Wu ZG, Lin XK, Zou X, Sun JM, He Q (2015) Biodegradable protein-based rockets for drug transportation and light-triggered release. ACS Appl Mater Interfaces 7(1):250–255. doi:10.1021/am507680u CrossRef Wu ZG, Lin XK, Zou X, Sun JM, He Q (2015) Biodegradable protein-based rockets for drug transportation and light-triggered release. ACS Appl Mater Interfaces 7(1):250–255. doi:10.​1021/​am507680u CrossRef
48.
go back to reference Xuan MJ, Shao JX, Dai LR, He Q, Li JB (2015) Macrophage cell membrane camouflaged mesoporous silica nanocapsules for in vivo cancer therapy. Adv Healthcare Mater 4(11):1645–1652. doi:10.1002/adhm.201500129 CrossRef Xuan MJ, Shao JX, Dai LR, He Q, Li JB (2015) Macrophage cell membrane camouflaged mesoporous silica nanocapsules for in vivo cancer therapy. Adv Healthcare Mater 4(11):1645–1652. doi:10.​1002/​adhm.​201500129 CrossRef
49.
go back to reference Gao CY, Lin ZH, Jurado-Sánchez B, Lin XK, Wu ZG, He Q (2016) Stem cell membrane-coated nanogels for highly efficient in vivo tumor targeted drug delivery. Small 12(30):4056–4062. doi:10.1002/smll.201600624 CrossRef Gao CY, Lin ZH, Jurado-Sánchez B, Lin XK, Wu ZG, He Q (2016) Stem cell membrane-coated nanogels for highly efficient in vivo tumor targeted drug delivery. Small 12(30):4056–4062. doi:10.​1002/​smll.​201600624 CrossRef
50.
go back to reference Gao CY, Wu ZG, Lin ZH, Lin XK, He Q (2016) Polymeric capsule-cushioned leukocyte cell membrane vesicles as a biomimetic delivery platform. Nanoscale 8(6):3548–3554. doi:10.1039/c5nr08407e CrossRef Gao CY, Wu ZG, Lin ZH, Lin XK, He Q (2016) Polymeric capsule-cushioned leukocyte cell membrane vesicles as a biomimetic delivery platform. Nanoscale 8(6):3548–3554. doi:10.​1039/​c5nr08407e CrossRef
52.
go back to reference Wu ZG, Li TL, Li JX, Gao W, Xu TL, Christianson C, Gao WW, Galarnyk M, He Q, Zhang LF, Wang J (2014) Turning erythrocytes into functional micromotors. ACS Nano 8(12):12041–12048. doi:10.1021/nn506200x CrossRef Wu ZG, Li TL, Li JX, Gao W, Xu TL, Christianson C, Gao WW, Galarnyk M, He Q, Zhang LF, Wang J (2014) Turning erythrocytes into functional micromotors. ACS Nano 8(12):12041–12048. doi:10.​1021/​nn506200x CrossRef
53.
go back to reference Wu ZG, de Avila BEF, Martin A, Christianson C, Gao WW, Thamphiwatana SK, Escarpa A, He Q, Zhang LF, Wang J (2015) RBC micromotors carrying multiple cargos towards potential theranostic applications. Nanoscale 7(32):13680–13686. doi:10.1039/c5nr03730a CrossRef Wu ZG, de Avila BEF, Martin A, Christianson C, Gao WW, Thamphiwatana SK, Escarpa A, He Q, Zhang LF, Wang J (2015) RBC micromotors carrying multiple cargos towards potential theranostic applications. Nanoscale 7(32):13680–13686. doi:10.​1039/​c5nr03730a CrossRef
54.
go back to reference Wu ZG, Li TL, Gao W, Xu TL, Jurado-Sánchez B, Li JX, Gao WW, He Q, Zhang LF, Wang J (2015) Cell-membrane-coated synthetic nanomotors for effective biodetoxification. Adv Funct Mater 25(25):3881–3887 Wu ZG, Li TL, Gao W, Xu TL, Jurado-Sánchez B, Li JX, Gao WW, He Q, Zhang LF, Wang J (2015) Cell-membrane-coated synthetic nanomotors for effective biodetoxification. Adv Funct Mater 25(25):3881–3887
56.
go back to reference Xuan MJ, Shao JX, Lin XK, Dai LR, He Q (2014) Self-propelled janus mesoporous silica nanomotors with sub-100 nm diameters for drug encapsulation and delivery. ChemPhysChem 15(11):2255–2260. doi:10.1002/cphc.201402111 CrossRef Xuan MJ, Shao JX, Lin XK, Dai LR, He Q (2014) Self-propelled janus mesoporous silica nanomotors with sub-100 nm diameters for drug encapsulation and delivery. ChemPhysChem 15(11):2255–2260. doi:10.​1002/​cphc.​201402111 CrossRef
57.
58.
go back to reference Wu ZG, Lin XK, Wu YJ, Si TY, Sun JM, He Q (2014) Near-infrared light-triggered “on/off” motion of polymer multilayer rockets. ACS Nano 8(6):6097–6105. doi:10.1021/nn501407r CrossRef Wu ZG, Lin XK, Wu YJ, Si TY, Sun JM, He Q (2014) Near-infrared light-triggered “on/off” motion of polymer multilayer rockets. ACS Nano 8(6):6097–6105. doi:10.​1021/​nn501407r CrossRef
Metadata
Title
Controlled Molecular Assembly Toward Self-propelled Micro-/Nanomotors
Authors
Xiankun Lin
Zhiguang Wu
Qiang He
Copyright Year
2017
Publisher
Springer Singapore
DOI
https://doi.org/10.1007/978-981-10-6059-5_11

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