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2011 | OriginalPaper | Chapter

18. Controlling Stem Cells with Biomaterials

Authors : Nivedita Sangaj, Shyni Varghese

Published in: Biomaterials for Tissue Engineering Applications

Publisher: Springer Vienna

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Abstract

Stem cell engineering has enormous potential to study developmental processes, disease progression, drug screening, and to provide new therapeutics. The interaction of stem cells with their microenvironment plays an important role in determining the stem cell fate. One of the most important environmental factors is the extracellular matrix, which defines the biochemical and biophysical niche from which the stem cells receive various regulatory signals. Artificial matrices based on natural and synthetic materials have been developed to direct stem cell fate such as proliferation and differentiation. Some of these approaches are being currently explored clinically and other more sophisticated multi-functional biomimetic materials with defined properties are currently under development. In this chapter we discuss some of the recent trends in the development of biomaterials and their applications in directing self-renewal and differentiation of stem cells.

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Metadata
Title
Controlling Stem Cells with Biomaterials
Authors
Nivedita Sangaj
Shyni Varghese
Copyright Year
2011
Publisher
Springer Vienna
Book
Biomaterials for Tissue Engineering Applications

Print ISBN: 978-3-7091-0384-5

Electronic ISBN: 978-3-7091-0385-2

Copyright Year: 2011

DOI
https://doi.org/10.1007/978-3-7091-0385-2_18

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