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2014 | OriginalPaper | Chapter

95. Design and Synthesis of 1H-2, 3-Dihydro-1-Pyrrolizinones Derivatives

Authors : Changhai Sun, Jing Cao

Published in: Proceedings of the 2012 International Conference on Applied Biotechnology (ICAB 2012)

Publisher: Springer Berlin Heidelberg

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Abstract

Pyrrolizinone derivatives were discovered showing remarkable anti-inflammatory and analgesic activities. Based on the SAR summarized before, a series of pyrrolizinone derivatives were designed and synthesized in this paper. All the eight target compounds were characterized by ¹HNMR spectra, and the test of anti-inflammatory and analgesic activities is in progress.

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Morriello GJ, Chicchi G, Johnson T et al (2010) Fused tricyclic pyrrolizinones that exhibit pseudo-irreversible blockade of the NK1 receptor. Bioorg Med Chem Lett 20(19):5925–5932CrossRef

Morriello GJ, Mills SG, Johnson T et al (2010) Substituted fused bicyclic pyrrolizinones as potent, orally bioavailable hNK1 antagonists. Bioorg Med Chem Lett 20(6):2007–2012CrossRef

Despinoy XL, McNab H (2009) 1-Methoxycarbonylpyrrolizin-3-one and related compounds. Org Biomol Chem 7(10):2187–2194CrossRef

Lescot E, Bureau R, Sopkova-de Oliveira Santos J et al (2005) 3D-QSAR and docking studies of selective GSK-3beta inhibitors. comparison with a thieno[2,3-b]pyrrolizinone derivative, a new potential lead for GSK-3beta ligands. J Chem Inf Model 45(3):708–715

Zhao LQ, Hu YD, Yuan Y et al (2001) Studied on docking of 5,6-diaryl-2,3-dihydro-1-pyrrolizinone derivatives with cyclooxygenase. Yao Xue Xue Bao 36(6):415–418

Zhao LQ, Yuan Y, Hu YD et al 3D-QSAR of antiinflammatory activities of 5,6-diaryl-2,3-dihydro-1-pyrrolizinone derivatives]. Yao Xue Xue Bao. 36(5):343–346

Zhao LQ, Yang Z, Zhang SF (2001) 5, 6-diaryl-2, 3-dihydro-1-pyrrolizinone derivatives synthesis and antiiflammatory and analgesic activities. Yao Xue Xue Bao 36(4):258–261

Zhang SF, Gao WF, Hen HZ (1988) Synthesis of 3H-1, 2-dihydro-1-pyrrolizinone derivatives. Yao Xue Xue Bao 23(1):28–33

Title: Design and Synthesis of 1H-2, 3-Dihydro-1-Pyrrolizinones Derivatives
Authors: Changhai Sun
Jing Cao
Publisher: Springer Berlin Heidelberg
Book: Proceedings of the 2012 International Conference on Applied Biotechnology (ICAB 2012)
Print ISBN: 978-3-642-37921-5

Electronic ISBN: 978-3-642-37922-2

Copyright Year: 2014
DOI: https://doi.org/10.1007/978-3-642-37922-2_95

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