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In Vivo Left Ventricular Geometry and Boundary Conditions Read chapter Read first chapter

2010 | OriginalPaper | Chapter

4. Determination of Myocardial Material Properties by Optimization

Authors : Jonathan F. Wenk, Choon-Sik Jhun, Kay Sun, Nielen Stander, Julius M. Guccione

Published in: Computational Cardiovascular Mechanics

Publisher: Springer US

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Abstract

The previous chapter includes a computationally efficient strain energy function for describing the three-dimensional relationship between stress and strain in passive myocardial material properties, the material parameters of which were formally optimized using left ventricular pressure and epicardial strain measurements in a cylindrical model. Results from such a model are confined at best to the equatorial region of the left ventricle. A finite element model of the entire left ventricle is required to determine regional variations in myocardial material properties. The most important or at least interesting finding from such a study is that myocardial contractility in the (border zone) region adjacent to a myocardial infarction is much less than (typically only half) that in regions remote from the myocardial infarction. This finding has been confirmed with active stress measurements in skinned muscle fibers dissected from these regions. This chapter is concerned with brief descriptions of the studies from our laboratory that have led up to our current knowledge concerning regional variations of myocardial contractility in infarcted left ventricles.

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Metadata
Title
Determination of Myocardial Material Properties by Optimization
Authors
Jonathan F. Wenk
Choon-Sik Jhun
Kay Sun
Nielen Stander
Julius M. Guccione
Copyright Year
2010
Publisher
Springer US
Book
Computational Cardiovascular Mechanics

Print ISBN: 978-1-4419-0729-5

Electronic ISBN: 978-1-4419-0730-1

Copyright Year: 2010

DOI
https://doi.org/10.1007/978-1-4419-0730-1_4