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03-02-2023 | Original Research

Development of chlorine dioxide sustained-release device using carboxymethyl cellulose-polyvinyl alcohol-β-cyclodextrin ternary hydrogel and a new sustained-release kinetic model

Authors: Yanan Wang, Hanyu Zhao, Lijie Huang, Guangxue Chen, Zhehao Wei, Qi Mo, Yishan Li, Xiyue Wang, Chongxing Huang, Qifeng Chen

Published in: Cellulose | Issue 5/2023

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Abstract

Owing to unique physiochemical and biological properties as well as the ability to be combined with a wide variety of materials for both biocompatibility and hydrophilia, carboxymethyl cellulose (CMC) is an excellent choice as a carrier. Loading Chlorine dioxide (ClO₂) into biodegradable carrier for its good disinfection performance and high safety factors has attracted significantattention. Therefore, in this study, we used ClO₂ as a model drug, and a sustained-ClO₂-gas-release gel was developed from degradable materials, such as carboxymethyl cellulose (CMC), polyvinyl alcohol (PVA), and β-cyclodextrin (βCD), through a simple and benign crosslinking strategy. Notably, the gel had sustained-release property in a wide temperature range of 4–35 ℃ and released ClO₂ gas effectively for more than 30 days. Furthermore, a loss factor was proposed based on the incomplete release of the drug in the sustained release process to a chieve a good fit with the gas diffusion process. A new diffusion model was designed based on the Korsmeyer–Peppas model, and an excellent fit was obtained. This sustained-ClO₂-gas-release gel provides theoretical and technical guidance for the development of sustained-disinfectant-release agents for use in space and offers new insights into the sustained release model of skeleton-soluble hydrogels.

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Title: Development of chlorine dioxide sustained-release device using carboxymethyl cellulose-polyvinyl alcohol-β-cyclodextrin ternary hydrogel and a new sustained-release kinetic model
Authors: Yanan Wang
Hanyu Zhao
Lijie Huang
Guangxue Chen
Zhehao Wei
Qi Mo
Yishan Li
Xiyue Wang
Chongxing Huang
Qifeng Chen
Publication date: 03-02-2023
Publisher: Springer Netherlands
Published in: Cellulose / Issue 5/2023
Print ISSN: 0969-0239
Electronic ISSN: 1572-882X
DOI: https://doi.org/10.1007/s10570-023-05070-6

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