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Published in:
2007 | OriginalPaper | Chapter
Dimerization and Oligomerization of Rhodopsin and Other G Protein-Coupled Receptors
Authors : Sławomir Filipek, Anna Modzelewska, Krystiana A. KrzyŚko
Published in: Molecular Materials with Specific Interactions – Modeling and Design
Publisher: Springer Netherlands
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Dimerization, and more generally oligomerization, of G protein-coupled receptors (GPCRs) is experimentally proven and possibly all GPCRs act in oligomeric form. The coupling with G protein, phosphorylation by kinase and binding to arrestin what starts internalization process have also been shown to be influenced by the oligomeric state of the receptors. Cooperative interactions within homo- and heterodimers of GPCRs may be critical for the propagation of an external signal across the cell membrane, activation of a G protein and passing the signal down to effector proteins