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Published in:
2012 | OriginalPaper | Chapter
Discovery of Complex Genomic Rearrangements in Cancer Using High-Throughput Sequencing
Authors : Andrew McPherson, Chunxiao Wu, Alexander Wyatt, Sohrab Shah, Colin Collins, S. Cenk Sahinalp
Published in: Research in Computational Molecular Biology
Publisher: Springer Berlin Heidelberg
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High-throughput sequencing now allows researchers to identify patterns of rearrangement in tumour genomes, and has led to the discovery of Complex Genomic Rearrangements (CGRs) as a new cytogenetic feature of some cancers. Closed chain breakage and rejoining (CCBR), a generalization of reciprocal translocation, was recently identified in prostate cancer [4]. CCBRs involve the balanced rearrangement of some
n
loci, and thus have the potential to fuse or interrupt up to
n
genes. In addition, dispersed throughout some breast cancer genomes are ‘genomic shards’, small fragments of DNA originating from elsewhere in the genome and inserted at the breakpoints of larger scale rearrangements.