Skip to main content
Top

Hint

Swipe to navigate through the chapters of this book

2020 | OriginalPaper | Chapter

Early Signs of Critical Slowing Down in Heart Surface Electrograms of Ventricular Fibrillation Victims

Authors : Berend Nannes, Rick Quax, Hiroshi Ashikaga, Mélèze Hocini, Remi Dubois, Olivier Bernus, Michel Haïssaguerre

Published in: Computational Science – ICCS 2020

Publisher: Springer International Publishing

share
SHARE

Abstract

Ventricular fibrillation (VF) is a dangerous type of cardiac arrhythmia which, without intervention, almost always results in sudden death. Implantable automatic defibrillators are among the most successful devices to prevent sudden death by automatically applying a shock to the heart when fibrillation occurs. However, the electric shock is very painful and could lead to dangerous situations when a patient is, for example, driving or biking. An early warning signal for VF could reduce the risk in such situations or, in the future, reduce the need for defibrillation altogether. Here, we test for the presence of critical slowing down (CSD), which has proven to be an early warning indicator for critical transitions in a range of different systems. CSD is characterized by a buildup of autocorrelation; we therefore study the residuals of heart surface electrocardiograms (ECGs) of patients that suffered VF to investigate if we can measure positive trends in autocorrelation. We consider several methods to extract these residuals from the original signals. For three out of four VF victims, we find a significant amount of positive autocorrelation trends in the residuals, which might be explained by CSD. We show that these positive trends may not be measurable from the original body surface ECGs, but only from certain areas around the heart surface. We argue that additional experimental studies involving heart surface ECG data of subjects that did not suffer VF are required to quantify the prediction accuracy of the promising results we get from the data of VF victims.
Appendix
Available only for authorised users
Literature
1.
go back to reference Amann, A., Tratnig, K., Unterkofler, K.: Reliability of old and new ventricular fibrillation detection algorithms for automated external defibrillators. Biomed. Tech./Biomed. Eng. 48, 216–217 (2003) CrossRef Amann, A., Tratnig, K., Unterkofler, K.: Reliability of old and new ventricular fibrillation detection algorithms for automated external defibrillators. Biomed. Tech./Biomed. Eng. 48, 216–217 (2003) CrossRef
2.
go back to reference Ahmad, M., Bloomstein, L.Z., Roelke, M., Bernstein, A.D., Parsonnet, V.: Patients’ attitudes toward implanted defibrillator shocks. Pacing Clin. Electrophysiol. 23(6), 934–938 (2000) CrossRef Ahmad, M., Bloomstein, L.Z., Roelke, M., Bernstein, A.D., Parsonnet, V.: Patients’ attitudes toward implanted defibrillator shocks. Pacing Clin. Electrophysiol. 23(6), 934–938 (2000) CrossRef
3.
go back to reference Sears, S.F., Conti, J.B.: Quality of life and psychological functioning of ICD patients. Heart 87(5), 488–493 (2002) CrossRef Sears, S.F., Conti, J.B.: Quality of life and psychological functioning of ICD patients. Heart 87(5), 488–493 (2002) CrossRef
4.
go back to reference Lane, R.: Prediction and prevention of sudden cardiac death in heart failure. Heart 91(5), 674–680 (2005) CrossRef Lane, R.: Prediction and prevention of sudden cardiac death in heart failure. Heart 91(5), 674–680 (2005) CrossRef
5.
go back to reference Reed, M., Robertson, C., Addison, P.: Heart rate variability measurements and the prediction of ventricular arrhythmias. QJM 98(2), 87–95 (2005) CrossRef Reed, M., Robertson, C., Addison, P.: Heart rate variability measurements and the prediction of ventricular arrhythmias. QJM 98(2), 87–95 (2005) CrossRef
6.
go back to reference Scheffer, M., et al.: Early-warning signals for critical transitions. Nature 461(7260), 53–59 (2009) CrossRef Scheffer, M., et al.: Early-warning signals for critical transitions. Nature 461(7260), 53–59 (2009) CrossRef
7.
go back to reference Wissel, C.: A universal law of the characteristic return time near thresholds. Oecologia 65(1), 101–107 (1984) CrossRef Wissel, C.: A universal law of the characteristic return time near thresholds. Oecologia 65(1), 101–107 (1984) CrossRef
8.
go back to reference Scheffer, M., Dakos, V., Nes, E., Brovkin, V., Petoukhov, V., Held, H.: Slowing down as an early warning signal for abrupt climate change. Proc. Natl. Acad. Sci. 105(38), 14308–14312 (2008) CrossRef Scheffer, M., Dakos, V., Nes, E., Brovkin, V., Petoukhov, V., Held, H.: Slowing down as an early warning signal for abrupt climate change. Proc. Natl. Acad. Sci. 105(38), 14308–14312 (2008) CrossRef
9.
go back to reference McSharry, P., Smith, L., Tarassenko, L.: Prediction of epileptic seizures: are nonlinear methods relevant? Nat. Med. 9(3), 241–242 (2003) CrossRef McSharry, P., Smith, L., Tarassenko, L.: Prediction of epileptic seizures: are nonlinear methods relevant? Nat. Med. 9(3), 241–242 (2003) CrossRef
10.
go back to reference Goldberger, A., Bhargava, V., West, B., Mandell, A.: Some observations on the question: is ventricular fibrillation “chaos”? Phys. D 19(2), 282–289 (1986) MathSciNetCrossRef Goldberger, A., Bhargava, V., West, B., Mandell, A.: Some observations on the question: is ventricular fibrillation “chaos”? Phys. D 19(2), 282–289 (1986) MathSciNetCrossRef
11.
go back to reference Surawicz, B.: Ventricular fibrillation. Am. J. Cardiol. 28(3), 268–287 (1971) CrossRef Surawicz, B.: Ventricular fibrillation. Am. J. Cardiol. 28(3), 268–287 (1971) CrossRef
12.
go back to reference Kaplan, D., Cohen, R.: Is fibrillation chaos? Circ. Res. 67(4), 886–892 (1990) CrossRef Kaplan, D., Cohen, R.: Is fibrillation chaos? Circ. Res. 67(4), 886–892 (1990) CrossRef
13.
go back to reference Garfinkel, A., et al.: Quasiperiodicity and chaos in cardiac fibrillation. J. Clin. Invest. 99(2), 305–314 (1997) CrossRef Garfinkel, A., et al.: Quasiperiodicity and chaos in cardiac fibrillation. J. Clin. Invest. 99(2), 305–314 (1997) CrossRef
14.
go back to reference Wit, A., Cranefield, P.: Reentrant excitation as a cause of cardiac arrhythmias. Am. J. Physiol. Heart Circ. Physiol. 235(1), H1–H17 (1978) CrossRef Wit, A., Cranefield, P.: Reentrant excitation as a cause of cardiac arrhythmias. Am. J. Physiol. Heart Circ. Physiol. 235(1), H1–H17 (1978) CrossRef
15.
go back to reference Weiss, J., et al.: The dynamics of cardiac fibrillation. Circulation 112(8), 1232–1240 (2005) CrossRef Weiss, J., et al.: The dynamics of cardiac fibrillation. Circulation 112(8), 1232–1240 (2005) CrossRef
16.
go back to reference Weiss, J., Garfinkel, A., Karagueuzian, H., Qu, Z., Chen, P.: Chaos and the transition to ventricular fibrillation. Circulation 99(21), 2819–2826 (1999) CrossRef Weiss, J., Garfinkel, A., Karagueuzian, H., Qu, Z., Chen, P.: Chaos and the transition to ventricular fibrillation. Circulation 99(21), 2819–2826 (1999) CrossRef
17.
go back to reference Qu, Z.: Chaos in the genesis and maintenance of cardiac arrhythmias. Prog. Biophys. Mol. Biol. 105(3), 247–257 (2011) CrossRef Qu, Z.: Chaos in the genesis and maintenance of cardiac arrhythmias. Prog. Biophys. Mol. Biol. 105(3), 247–257 (2011) CrossRef
18.
go back to reference Qu, Z., Hu, G., Garfinkel, A., Weiss, J.: Nonlinear and stochastic dynamics in the heart. Phys. Rep. 543(2), 61–162 (2014) MathSciNetCrossRef Qu, Z., Hu, G., Garfinkel, A., Weiss, J.: Nonlinear and stochastic dynamics in the heart. Phys. Rep. 543(2), 61–162 (2014) MathSciNetCrossRef
19.
go back to reference Gulrajani, R.: The forward and inverse problems of electrocardiography. IEEE Eng. Med. Biol. Mag. 17(5), 84–101, 122 (1998) Gulrajani, R.: The forward and inverse problems of electrocardiography. IEEE Eng. Med. Biol. Mag. 17(5), 84–101, 122 (1998)
20.
go back to reference Suppappola, S., Sun, Y., Chiaramida, S.: Gaussian pulse decomposition: an intuitive model of electrocardiogram waveforms. Ann. Biomed. Eng. 25(2), 252–260 (1997) CrossRef Suppappola, S., Sun, Y., Chiaramida, S.: Gaussian pulse decomposition: an intuitive model of electrocardiogram waveforms. Ann. Biomed. Eng. 25(2), 252–260 (1997) CrossRef
22.
go back to reference Goldberger, A., et al.: PhysioBank, PhysioToolkit, and PhysioNet. Circulation 101(23), e215–e220 (2000) CrossRef Goldberger, A., et al.: PhysioBank, PhysioToolkit, and PhysioNet. Circulation 101(23), e215–e220 (2000) CrossRef
Metadata
Title
Early Signs of Critical Slowing Down in Heart Surface Electrograms of Ventricular Fibrillation Victims
Authors
Berend Nannes
Rick Quax
Hiroshi Ashikaga
Mélèze Hocini
Remi Dubois
Olivier Bernus
Michel Haïssaguerre
Copyright Year
2020
DOI
https://doi.org/10.1007/978-3-030-50423-6_25