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16-04-2024 | Research Article

Effect of adult hippocampal neurogenesis on pattern separation and its applications

Authors: Zengbin Wang, Kai Yang, Xiaojuan Sun

Published in: Cognitive Neurodynamics

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Abstract

Adult hippocampal neurogenesis (AHN) is considered essential in memory formation. The dentate gyrus neural network containing newborn dentate gyrus granule cells at the critical period (4–6 weeks) have been widely discussed in neurophysiological and behavioral experiments. However, how newborn dentate gyrus granule cells at this critical period influence pattern separation of dentate gyrus remains unclear. To address this issue, we propose a biologically related dentate gyrus neural network model with AHN. By Leveraging this model, we find pattern separation is enhanced at the medium level of neurogenesis (5% of mature granule cells). This is because the sparse firing of mature granule cells is increased. We can understand this change from the following two aspects. On one hand, newborn granule cells compete with mature granule cells for inputs from the entorhinal cortex, thereby weakening the firing of mature granule cells. On the other hand, newborn granule cells effectively enhance the feedback inhibition level of the network by promoting the firing of interneurons (Mossy cells and Basket cells) and then indirectly regulating the sparse firing of mature granule cells. To verify the validity of the model for pattern separation, we apply the proposed model to a similar concept separation task and reveal that our model outperforms the original model counterparts in this task.

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Metadata
Title
Effect of adult hippocampal neurogenesis on pattern separation and its applications
Authors
Zengbin Wang
Kai Yang
Xiaojuan Sun
Publication date
16-04-2024
Publisher
Springer Netherlands
Published in
Cognitive Neurodynamics
Print ISSN: 1871-4080
Electronic ISSN: 1871-4099
DOI
https://doi.org/10.1007/s11571-024-10110-3