Skip to main content
Top

2015 | OriginalPaper | Chapter

55. Effect of Manchurian Walnut Extracts on Cancer Cells Proliferation

Authors : Changcai Zhao, Xing Niu, Rui Huang, Jiali Dong, Yuyin Li, Aipo Diao

Published in: Advances in Applied Biotechnology

Publisher: Springer Berlin Heidelberg

Activate our intelligent search to find suitable subject content or patents.

search-config
loading …

Abstract

Extracts from the Manchurian walnut have the antibacterial, anti-inflammatory, and anticancer properties. In this study, different extracts were obtained from Manchurian walnut peels, flowers, and leaves by the Soxhlet extraction method, and used to study the antitumor activity. MTT assay shows that the ethyl acetate phase of the peels inhibits cell proliferation of colon cancer cell SW480 with an IC50 at 56 μg/mL. Hoechst 33258 staining illustrates that the ethyl acetate phase of the peels induces cell apoptosis of SW480 cells. These results indicate that the ethyl acetate of Manchurian walnut peels inhibits cell proliferation and promotes cell apoptosis of cancer cells.

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Literature
1.
go back to reference Cantero-Muñoz P, Urién MA, Ruano-Ravina A (2011) Efficacy and safety ofintraoperative radiotherapy in colorectal cancer: a systematic review. Cancer Lett 306(2):121–133CrossRef Cantero-Muñoz P, Urién MA, Ruano-Ravina A (2011) Efficacy and safety ofintraoperative radiotherapy in colorectal cancer: a systematic review. Cancer Lett 306(2):121–133CrossRef
2.
go back to reference Khuloud B, Jan S, Stefanie D et al (2012) The anticancer effect of saffron in two p53 isogenic colorectal cancer cell lines. BMC Complement Altern Med. doi:10.1186/1472-6882-12-69 Khuloud B, Jan S, Stefanie D et al (2012) The anticancer effect of saffron in two p53 isogenic colorectal cancer cell lines. BMC Complement Altern Med. doi:10.​1186/​1472-6882-12-69
3.
go back to reference Storli KE, Søndenaa K, Bukholm IR et al (2011) Overall survival after resection for colon cancer in a national cohort study was adversely affected by TNM stage, lymph node ratio, gender, and old age. Int J Colorectal Dis 26(10):1299–1307CrossRef Storli KE, Søndenaa K, Bukholm IR et al (2011) Overall survival after resection for colon cancer in a national cohort study was adversely affected by TNM stage, lymph node ratio, gender, and old age. Int J Colorectal Dis 26(10):1299–1307CrossRef
4.
go back to reference Shan D, Bing H, Hongmei A et al (2013) Teng-Long-Bu-Zhong-Tang, a Chinese herbal formula, enhances anticancer effects of 5–fluor ouracil in CT26 colon carcinoma. BMC Complement Altern Med. doi:10.1186/1472-6882-13-128 Shan D, Bing H, Hongmei A et al (2013) Teng-Long-Bu-Zhong-Tang, a Chinese herbal formula, enhances anticancer effects of 5–fluor ouracil in CT26 colon carcinoma. BMC Complement Altern Med. doi:10.​1186/​1472-6882-13-128
5.
go back to reference Aithal KB, Rao SB, Sunil K et al (2012) Tumor growth inhibitory effect of juglone and its radiation sensitizing potential. In vivo and in vitro studies. Integr Cancer Ther 11(1):68–80CrossRef Aithal KB, Rao SB, Sunil K et al (2012) Tumor growth inhibitory effect of juglone and its radiation sensitizing potential. In vivo and in vitro studies. Integr Cancer Ther 11(1):68–80CrossRef
6.
go back to reference Bhatia K, Rahman S, Ali M et al (2006) In vitro antioxidant activity of Juglans regiaL bark extract and its protective effect on cyclophosphamide induced urotoxicity in mice. Redox Rep 11(6):273–279CrossRef Bhatia K, Rahman S, Ali M et al (2006) In vitro antioxidant activity of Juglans regiaL bark extract and its protective effect on cyclophosphamide induced urotoxicity in mice. Redox Rep 11(6):273–279CrossRef
7.
go back to reference Blumenthal M (1998) Walnut Hull. The complete german commission E monographs. American Botanical Council, Austin Blumenthal M (1998) Walnut Hull. The complete german commission E monographs. American Botanical Council, Austin
8.
go back to reference Duke JA, Ayensu ES (1985) Medicinal plants of China. Ann Soc Belg Med Trop 65(2):117–120 Duke JA, Ayensu ES (1985) Medicinal plants of China. Ann Soc Belg Med Trop 65(2):117–120
9.
go back to reference Bhargava UC, Westfall BA (1968) Antitumor activity of Juglansniga (black walnut) extractives. J Pharm Sci 57(10):1674–1677CrossRef Bhargava UC, Westfall BA (1968) Antitumor activity of Juglansniga (black walnut) extractives. J Pharm Sci 57(10):1674–1677CrossRef
10.
go back to reference Paulsen MT, Ljungman M (2005) The natural toxin juglone causes degradation of p53 and inducesrapid H2AX phosphorylation and cell death in human fibroblasts. Toxicol Appl Pharmacol 209(1):1–9CrossRef Paulsen MT, Ljungman M (2005) The natural toxin juglone causes degradation of p53 and inducesrapid H2AX phosphorylation and cell death in human fibroblasts. Toxicol Appl Pharmacol 209(1):1–9CrossRef
11.
go back to reference Babula P, Adam V, Havel L et al (2007) Naphthoquinones and their pharmacological properties. Ceska Slov Farm 56(3):114–120 Babula P, Adam V, Havel L et al (2007) Naphthoquinones and their pharmacological properties. Ceska Slov Farm 56(3):114–120
12.
go back to reference Iatropoulos MJ, Williams GM (1996) Proliferation markers. Exp Toxicol Pathol 48(2–3):175–181CrossRef Iatropoulos MJ, Williams GM (1996) Proliferation markers. Exp Toxicol Pathol 48(2–3):175–181CrossRef
13.
go back to reference Balleine RL, Webster LR, Davis S et al (2008) Molecular grading of ductal carcinoma in situ of the breast. Clin Cancer Res 14(24):8244–8252CrossRef Balleine RL, Webster LR, Davis S et al (2008) Molecular grading of ductal carcinoma in situ of the breast. Clin Cancer Res 14(24):8244–8252CrossRef
14.
go back to reference Fang L, Cheng Q, Li W et al (2014) Antitumor activities of an oncolytic adenovirus equipped with a double siRNA targeting Ki67 and hTERT in renal cancer cells. Virus Res 181:61–71CrossRef Fang L, Cheng Q, Li W et al (2014) Antitumor activities of an oncolytic adenovirus equipped with a double siRNA targeting Ki67 and hTERT in renal cancer cells. Virus Res 181:61–71CrossRef
Metadata
Title
Effect of Manchurian Walnut Extracts on Cancer Cells Proliferation
Authors
Changcai Zhao
Xing Niu
Rui Huang
Jiali Dong
Yuyin Li
Aipo Diao
Copyright Year
2015
Publisher
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-662-45657-6_55

Premium Partners