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Journal of Polymer Research
Published in: Journal of Polymer Research 6/2019

01-06-2019 | ORIGINAL PAPER

Effects of amylose content on starch-chitosan composite film and its application as a wound dressing

Authors: Wen-Ching Wu, Po-Yuan Hsiao, Yi-Cheng Huang

Published in: Journal of Polymer Research | Issue 6/2019

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Abstract

This study analyzed the amylose content of starches and used them to prepare starch–chitosan composite films to assess their potential as wound dressings. Amylose content was 35.3% in potato starch, 30.5% in corn starch, and 9.7% in glutinous rice starch. The glutinous rice starch–chitosan composite (GC) film, which had a lower amylose content, had a coarser surface and exhibited a higher swelling rate, tensile strength, and elongation at break. In in vitro experiments by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay indicated that GC film had greater biocompatibility with mouse fibroblast L929 cells and human keratinocyte HaCaT cells. The results of the enzyme-linked immunosorbent assay indicated that GC film was more capable of alleviating inflammation than other films by preventing RAW264.7 macrophage from secreting cytokines (TNF-α and IL-6). Additionally, it possessed an excellent coagulation rate. Briefly, the GC film with a lower amylose content is a suitable material for wound dressing.
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Metadata
Title
Effects of amylose content on starch-chitosan composite film and its application as a wound dressing
Authors
Wen-Ching Wu
Po-Yuan Hsiao
Yi-Cheng Huang
Publication date
01-06-2019
Publisher
Springer Netherlands
Published in
Journal of Polymer Research / Issue 6/2019
Print ISSN: 1022-9760
Electronic ISSN: 1572-8935
DOI
https://doi.org/10.1007/s10965-019-1770-0

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