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2013 | OriginalPaper | Chapter

34. Effects of Hemoglobin-Based Oxygen Carriers on Blood Coagulation

Authors : Jonathan S. Jahr, Molly Chung, Afsaneh Anvarhosseini, Hae Won Kim

Published in: Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics

Publisher: Springer Berlin Heidelberg

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Abstract

There have been at least two major concerns with use of HBOCs as resuscitation fluids for traumatic hemorrhage: potential coagulopathy and interference with conventional clinical laboratory coagulation measurements.

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Literature
go back to reference Abe H, Fujihara M, Azuma H, Ikeda H, Ikebuchi K, Takeoka S, Tsuchida E, Harashima H (2006) Interaction of hemoglobin vesicles, a cellular-type artificial oxygen carrier with human plasma: effects on coagulation, kallikrein-kinin, and complement systems. Artif Cell Blood Substit Immobil Biotecnol 34(1):1–10CrossRef Abe H, Fujihara M, Azuma H, Ikeda H, Ikebuchi K, Takeoka S, Tsuchida E, Harashima H (2006) Interaction of hemoglobin vesicles, a cellular-type artificial oxygen carrier with human plasma: effects on coagulation, kallikrein-kinin, and complement systems. Artif Cell Blood Substit Immobil Biotecnol 34(1):1–10CrossRef
go back to reference Arnaud F, Handrigan M (2006) Coagulation patterns following hemoglobin-based oxygen carrier resuscitation in severe uncontrolled hemorrhagic shock in swine. Transfusion Med 16:290–302CrossRef Arnaud F, Handrigan M (2006) Coagulation patterns following hemoglobin-based oxygen carrier resuscitation in severe uncontrolled hemorrhagic shock in swine. Transfusion Med 16:290–302CrossRef
go back to reference Arnaud F, Hammett M, Asher L, Philbin N, Rice J, Dong F, Pearce B, Flournoy WS, Nicholson C, McCarron R, Freilich D (2005) Effects of bovine polymerized hemoglobin on coagulation in controlled hemorrhagic shock in swine. Shock 24(2):145–152CrossRef Arnaud F, Hammett M, Asher L, Philbin N, Rice J, Dong F, Pearce B, Flournoy WS, Nicholson C, McCarron R, Freilich D (2005) Effects of bovine polymerized hemoglobin on coagulation in controlled hemorrhagic shock in swine. Shock 24(2):145–152CrossRef
go back to reference Arnaud F, Fasipe D, Philbin N, Rice J, Flournoy WS, Ahlers A, James MF (2007) Hele′t E, Potgieter, Ellis P, McCarron R, Freilich D. Hematology patterns after hemoglobin-based oxygen carrier resuscitation from severe controlled hemorrhage with prolonged delayed definitive care. Transfusion 47:2098–2109CrossRef Arnaud F, Fasipe D, Philbin N, Rice J, Flournoy WS, Ahlers A, James MF (2007) Hele′t E, Potgieter, Ellis P, McCarron R, Freilich D. Hematology patterns after hemoglobin-based oxygen carrier resuscitation from severe controlled hemorrhage with prolonged delayed definitive care. Transfusion 47:2098–2109CrossRef
go back to reference Belgrave RL, Hines MT, Keegan RD, Wardrop KJ, Bayly WM, Sellon DC (2002) Effects of a polymerized ultrapurified bovine hemoglobin blood substitute administered to ponies with normovolemic anemia. J Vet Intern Med 16(4):396–403CrossRef Belgrave RL, Hines MT, Keegan RD, Wardrop KJ, Bayly WM, Sellon DC (2002) Effects of a polymerized ultrapurified bovine hemoglobin blood substitute administered to ponies with normovolemic anemia. J Vet Intern Med 16(4):396–403CrossRef
go back to reference Browdie D, Smith H (1975) Stroma-free hemoglobin. Simplied preparation and in vivo and in vitro effects on coagulation in rabbits. Am J Surg 129(4):365–368CrossRef Browdie D, Smith H (1975) Stroma-free hemoglobin. Simplied preparation and in vivo and in vitro effects on coagulation in rabbits. Am J Surg 129(4):365–368CrossRef
go back to reference Cabrales P, Sun G, Zhou Y, Harris DR, Tsai AG, Intaglietta M, Palmer AF (2009) Effects of the molecular mass of tense-state polymerized bovine hemoglobin on blood pressure and vasoconstriction. J Appl Phys 107:1548–1558 Cabrales P, Sun G, Zhou Y, Harris DR, Tsai AG, Intaglietta M, Palmer AF (2009) Effects of the molecular mass of tense-state polymerized bovine hemoglobin on blood pressure and vasoconstriction. J Appl Phys 107:1548–1558
go back to reference Chen J-Y, Scerbo M, Kramer G (2009) A review of blood substitutes: examing the history, clinical trial results, and ethics of hemoglobin-based oxygen carriers. Clinics (São Paulo) 64:803–813 Chen J-Y, Scerbo M, Kramer G (2009) A review of blood substitutes: examing the history, clinical trial results, and ethics of hemoglobin-based oxygen carriers. Clinics (São Paulo) 64:803–813
go back to reference Dade PFA-100 Reagents Package Insert. Newark, DE: Dade Behring Inc; 2005 Dade PFA-100 Reagents Package Insert. Newark, DE: Dade Behring Inc; 2005
go back to reference Darlington DN, Delgado AV, Kheirabadi BS, Fedyk CG, Scherer MR, Pusateri AE, Wade CE, Cap AP, Holcomb JB, Dubick MA (2011) Effect of hemodilution on coagulation and recombinant factor VIIa efficacy in human blood in vitro. J Trauma-injury Infect Crit Care 71:1152–1163CrossRef Darlington DN, Delgado AV, Kheirabadi BS, Fedyk CG, Scherer MR, Pusateri AE, Wade CE, Cap AP, Holcomb JB, Dubick MA (2011) Effect of hemodilution on coagulation and recombinant factor VIIa efficacy in human blood in vitro. J Trauma-injury Infect Crit Care 71:1152–1163CrossRef
go back to reference Deusch E, Gamsjager T, Kress HG et al (2003) Binding of hydroxyethyl starch molecules to the platelet surface. Anesth Analg 97:680–683CrossRef Deusch E, Gamsjager T, Kress HG et al (2003) Binding of hydroxyethyl starch molecules to the platelet surface. Anesth Analg 97:680–683CrossRef
go back to reference Ekseth K, Abildgaard L, Vegfors M, Berg-Johnsen J, Engdahl O (2002) The in vitro effects of crystalloids and colloids on coagulation. Anaesthesia 57:1102–1108CrossRef Ekseth K, Abildgaard L, Vegfors M, Berg-Johnsen J, Engdahl O (2002) The in vitro effects of crystalloids and colloids on coagulation. Anaesthesia 57:1102–1108CrossRef
go back to reference Favaloro EJ (2002) Clinical application of the PFA-100. Curr Opin Haematol 9:407–415CrossRef Favaloro EJ (2002) Clinical application of the PFA-100. Curr Opin Haematol 9:407–415CrossRef
go back to reference Feola M, Simoni J, Canizaro PT, Tran R. Raschbaum G, Behal FJ, Lubbock (1988) Texas. Toxicity of polymerized hemoglobin solutions. Surg Gynecol Obstet 166:211–222 Feola M, Simoni J, Canizaro PT, Tran R. Raschbaum G, Behal FJ, Lubbock (1988) Texas. Toxicity of polymerized hemoglobin solutions. Surg Gynecol Obstet 166:211–222
go back to reference Harrison P, Robinson M, Liesner R et al (2002) The PFA-100: a potential rapid screening tool for the assessment of platelet dysfunction. Clin Lab Haematol 4:225–232CrossRef Harrison P, Robinson M, Liesner R et al (2002) The PFA-100: a potential rapid screening tool for the assessment of platelet dysfunction. Clin Lab Haematol 4:225–232CrossRef
go back to reference Hauser CJ, Boffard K, Dutton R, Bernard GR, Croce MA, Holcomb JB et al (2010) Results of the CONTROL trial: efficacy and safety of recombinant activated Factor VII in the management of refractory traumatic hemorrhage. J Trauma 69(3):489–500CrossRef Hauser CJ, Boffard K, Dutton R, Bernard GR, Croce MA, Holcomb JB et al (2010) Results of the CONTROL trial: efficacy and safety of recombinant activated Factor VII in the management of refractory traumatic hemorrhage. J Trauma 69(3):489–500CrossRef
go back to reference Huang Y, Komatsu T, Nakagawa A, Tsuchida E, Kobayashi S (2003) Compatibility in vitro of albumin-heme oxygen carrier with blood cell components. J Biomed Mater Res A 66(2):292–297CrossRef Huang Y, Komatsu T, Nakagawa A, Tsuchida E, Kobayashi S (2003) Compatibility in vitro of albumin-heme oxygen carrier with blood cell components. J Biomed Mater Res A 66(2):292–297CrossRef
go back to reference Huraux C, Ankri A, Eyraud D et al (2001) Hemostatic changes in patients receiving hydroxyethyl starch: The influence of ABO blood group. Anesth Analg 92:1396–1401CrossRef Huraux C, Ankri A, Eyraud D et al (2001) Hemostatic changes in patients receiving hydroxyethyl starch: The influence of ABO blood group. Anesth Analg 92:1396–1401CrossRef
go back to reference Iwasaki K, Iwashita Y, Ikeda K, Uematsu T (1986) Efficacy and saftey of hemoglobin-polyethlene glycol conjugate (pyridoxalated polyethylene glycol hemoglobin) as an oxygen-carrying resuscitation fluid. Artif Organs 10(6):470–474CrossRef Iwasaki K, Iwashita Y, Ikeda K, Uematsu T (1986) Efficacy and saftey of hemoglobin-polyethlene glycol conjugate (pyridoxalated polyethylene glycol hemoglobin) as an oxygen-carrying resuscitation fluid. Artif Organs 10(6):470–474CrossRef
go back to reference Jahr JS, Lurie F, Gosselin R, Lin JS, Wong L, Owings JT, Larkin E (2002) Effects of hemoglobin glutamer-250 (bovine) (HBOC-201, Hemopure) on coagulation testing. Am J Ther 9:431–436CrossRef Jahr JS, Lurie F, Gosselin R, Lin JS, Wong L, Owings JT, Larkin E (2002) Effects of hemoglobin glutamer-250 (bovine) (HBOC-201, Hemopure) on coagulation testing. Am J Ther 9:431–436CrossRef
go back to reference Jahr JS, Weeks DL, Desai P, Lim JC, Butch AW, Gunther RA, Driessen B (2008a) Does OxyVita, a new-generation hemoglobin-based oxygen carrier, or oxyglobin, acutely interfere with coagulation compared with normal saline or 6% hetastarch? An ex vivo thrombelastography study. J Cardiothorac Vasc Anesth 22:34–39CrossRef Jahr JS, Weeks DL, Desai P, Lim JC, Butch AW, Gunther RA, Driessen B (2008a) Does OxyVita, a new-generation hemoglobin-based oxygen carrier, or oxyglobin, acutely interfere with coagulation compared with normal saline or 6% hetastarch? An ex vivo thrombelastography study. J Cardiothorac Vasc Anesth 22:34–39CrossRef
go back to reference Jahr JS, Mackenzie C, Pearce B, Pitman A, Greenburg AG (2008b) HBOC-201 as an alternative to blood transfusion: efficacy and safety evaluation in a multicenter phase III trial in elective orthopedic surgery. J Trauma-Injury Infect Crit Care 64(6):1484–1497CrossRef Jahr JS, Mackenzie C, Pearce B, Pitman A, Greenburg AG (2008b) HBOC-201 as an alternative to blood transfusion: efficacy and safety evaluation in a multicenter phase III trial in elective orthopedic surgery. J Trauma-Injury Infect Crit Care 64(6):1484–1497CrossRef
go back to reference Jahr JS, Liu H, Albert O, Gull A, Moallempour M, Lim J, Gosselin R (2010) Does HBOC-201 (Hemopure) affect platelet function in orthopedic surgery: a single-site analysis from a multicenter study? Am J Ther 17:140–147CrossRef Jahr JS, Liu H, Albert O, Gull A, Moallempour M, Lim J, Gosselin R (2010) Does HBOC-201 (Hemopure) affect platelet function in orthopedic surgery: a single-site analysis from a multicenter study? Am J Ther 17:140–147CrossRef
go back to reference Jahr JS, Sadighi A, Doherty L, Li A, Kim HW (2011) In chemistry and biochemistry of oxygen therapeutics: from transfusion to artificial blood. Mozzarelli A, Bettati S (eds) (2011) John Wiley and Sons, Ltd., pp 301–316 Jahr JS, Sadighi A, Doherty L, Li A, Kim HW (2011) In chemistry and biochemistry of oxygen therapeutics: from transfusion to artificial blood. Mozzarelli A, Bettati S (eds) (2011) John Wiley and Sons, Ltd., pp 301–316
go back to reference Jahr JS, Sadighi Akha A, Holtby R (2012) Crosslinked, polymerized, and PEG-conjugated hemoglobin-based oxygen carriers: clinical safety and efficacy of recent and current products. publ Curr Drug Discov Technol 9:158–65 Jahr JS, Sadighi Akha A, Holtby R (2012) Crosslinked, polymerized, and PEG-conjugated hemoglobin-based oxygen carriers: clinical safety and efficacy of recent and current products. publ Curr Drug Discov Technol 9:158–65
go back to reference James MF (2004) Hele′t E, Potgieter, Ellis P. The effect of hemopure on coagulation in clinically relevant concentrations. Anesth Analg 99(6):1593–1597CrossRef James MF (2004) Hele′t E, Potgieter, Ellis P. The effect of hemopure on coagulation in clinically relevant concentrations. Anesth Analg 99(6):1593–1597CrossRef
go back to reference Jamnicki M, Bombeli T, Seifert B, Zollinger A, Camenzind V, Pasch T, Spahn DR (2000) Low- and medium-molecular-weight hydroxyethyl starches: comparison of their effect on blood coagulation. Anesthesiology 93(5):1231–1237CrossRef Jamnicki M, Bombeli T, Seifert B, Zollinger A, Camenzind V, Pasch T, Spahn DR (2000) Low- and medium-molecular-weight hydroxyethyl starches: comparison of their effect on blood coagulation. Anesthesiology 93(5):1231–1237CrossRef
go back to reference Johnson VV, Swiatkowski SA (2007) Scientific aspects of supplying blood to distant military theaters. Transfus Med 14:694–699 Johnson VV, Swiatkowski SA (2007) Scientific aspects of supplying blood to distant military theaters. Transfus Med 14:694–699
go back to reference Kim HW, Greenburg AG (2006) Toward 21st century blood component replacement therapeutics: artificial oxygen carriers, platelet substitutes, recombinant clotting factors, and others. Artif blood Substit Immobil Biotechnol 34:537–550CrossRef Kim HW, Greenburg AG (2006) Toward 21st century blood component replacement therapeutics: artificial oxygen carriers, platelet substitutes, recombinant clotting factors, and others. Artif blood Substit Immobil Biotechnol 34:537–550CrossRef
go back to reference Kim HW, Stubdal H, Greenburg AG (1992) Coagulation dynamics after hemodilution with polyhemoglobin. Surg Gynecol Obstet 175(219–26):22 Kim HW, Stubdal H, Greenburg AG (1992) Coagulation dynamics after hemodilution with polyhemoglobin. Surg Gynecol Obstet 175(219–26):22
go back to reference Lee DH, Bardossy L, Peterson N, Blajchman MA (2000) O-raffinose cross-linked hemoglobin improves the hemostatic defect associated with anemia and thrombocytopenia in rabbits. Blood 96(10):3630–3636 Lee DH, Bardossy L, Peterson N, Blajchman MA (2000) O-raffinose cross-linked hemoglobin improves the hemostatic defect associated with anemia and thrombocytopenia in rabbits. Blood 96(10):3630–3636
go back to reference Lefkowitz JB (2008) Coagulation pathway and physiology. In: Kottke-Marchant K (ed) An Algorithmic Approach to hemostasis testing. College of American Pathologists, Northfield, pp 3–12 Lefkowitz JB (2008) Coagulation pathway and physiology. In: Kottke-Marchant K (ed) An Algorithmic Approach to hemostasis testing. College of American Pathologists, Northfield, pp 3–12
go back to reference Leytin V, Mazer D, Mody M, Garvey B, Freedman J (2003) Hemolink, an o-raffinose cross link haemoglobin-based oxygen carrier, does not affect activation and function of human platelets in whole blood. Br J Haematol 120(3):535–541CrossRef Leytin V, Mazer D, Mody M, Garvey B, Freedman J (2003) Hemolink, an o-raffinose cross link haemoglobin-based oxygen carrier, does not affect activation and function of human platelets in whole blood. Br J Haematol 120(3):535–541CrossRef
go back to reference Mammen EF (1998) PFA-100 system: a new method for assesment of platelet dysfunction. Semin Thromb Haemost 24:195–202CrossRef Mammen EF (1998) PFA-100 system: a new method for assesment of platelet dysfunction. Semin Thromb Haemost 24:195–202CrossRef
go back to reference Moallempour M, Jahr JS, Lim JC, Weeks D, Butch A, Driessen B (2009) Methemoglobin effects on coagulation: a dose-response study with HBOC-200 (Oxyglobin) in a thrombelastogram model. J Cardiothorac Vasc Anesth 23(1):41–47CrossRef Moallempour M, Jahr JS, Lim JC, Weeks D, Butch A, Driessen B (2009) Methemoglobin effects on coagulation: a dose-response study with HBOC-200 (Oxyglobin) in a thrombelastogram model. J Cardiothorac Vasc Anesth 23(1):41–47CrossRef
go back to reference Ning J, Chang TM (1990) In vivo effects of stroma-free hemoglobin and polyhemoglobin on coagulation factors in rats. Int J Artif Organs 13(8):509–516 Ning J, Chang TM (1990) In vivo effects of stroma-free hemoglobin and polyhemoglobin on coagulation factors in rats. Int J Artif Organs 13(8):509–516
go back to reference Reid TE (2003) Hb-based oxygen carriers: are we there yet? Transfusion 43:280–287CrossRef Reid TE (2003) Hb-based oxygen carriers: are we there yet? Transfusion 43:280–287CrossRef
go back to reference Sakai H, Hara H, Yuasa M, Tsai AG, Takeoka S, Tsuchida E, Intaglietta M (2002) Am J Phys-Heart Circ Phys 279:H908– H915 Sakai H, Hara H, Yuasa M, Tsai AG, Takeoka S, Tsuchida E, Intaglietta M (2002) Am J Phys-Heart Circ Phys 279:H908– H915
go back to reference Savitsky JP, Doczi J, Black J, Arnold JD (1978) A clinical safety trial of stroma-free hemoglobin. Clin Pharmacol Ther 23(1):73–80 Savitsky JP, Doczi J, Black J, Arnold JD (1978) A clinical safety trial of stroma-free hemoglobin. Clin Pharmacol Ther 23(1):73–80
go back to reference Saxena R, Wijnhoud AD, Carton H, Hacke W, Kaste M, Przybelski RJ, Stern KN, Koudstaa PJ (1999) Stroke 30:993–996 Saxena R, Wijnhoud AD, Carton H, Hacke W, Kaste M, Przybelski RJ, Stern KN, Koudstaa PJ (1999) Stroke 30:993–996
go back to reference Standl T, Burmeister MA, Horn EP, Wilhelm S, Knoefel WT (1998) Schulte am Esch J. Bovine haemoglobin-based oxygen carrier for patients undergoing haemodilution before liver resection. Br J Anaesth 80(2):189–194CrossRef Standl T, Burmeister MA, Horn EP, Wilhelm S, Knoefel WT (1998) Schulte am Esch J. Bovine haemoglobin-based oxygen carrier for patients undergoing haemodilution before liver resection. Br J Anaesth 80(2):189–194CrossRef
go back to reference Strauss RG, Pennell BJ, Stump DC (2002) A randomized, blinded trial comparing the hemostatic effects of pentastarch versus hetastarch. Transfusion 42:27–36CrossRef Strauss RG, Pennell BJ, Stump DC (2002) A randomized, blinded trial comparing the hemostatic effects of pentastarch versus hetastarch. Transfusion 42:27–36CrossRef
go back to reference TEG (2005) 5000 User’s manual. Niles, IL, Haemoscope Inc, P 178 TEG (2005) 5000 User’s manual. Niles, IL, Haemoscope Inc, P 178
go back to reference Uszynski L, Schier J, Rudowski W, Daszynski J (1976) Effects of stroma-free haemoglobin solution on the blood-clotting system in dogs. Eur Surg Res 8(3):201–210 Uszynski L, Schier J, Rudowski W, Daszynski J (1976) Effects of stroma-free haemoglobin solution on the blood-clotting system in dogs. Eur Surg Res 8(3):201–210
go back to reference Weeks DL, Jahr JS, Lim JC, Butch AW, Driessen D (2008) Does Hextend® impair coagulation compared to 6% hetastarch: an ex vivo TEG study. Am J Ther 15:225–230CrossRef Weeks DL, Jahr JS, Lim JC, Butch AW, Driessen D (2008) Does Hextend® impair coagulation compared to 6% hetastarch: an ex vivo TEG study. Am J Ther 15:225–230CrossRef
go back to reference Williams JP, Tseuda K, Vandermeersch E, Bourke DL, Jahr JS (2002) Transfusion requirements in Phase III study of HBOC-201 (Hemopure®, Hemoglobin gutamer-250, bovine), a bovine hemoglobin based blood substitute. Transfusion 42:S49–030I Williams JP, Tseuda K, Vandermeersch E, Bourke DL, Jahr JS (2002) Transfusion requirements in Phase III study of HBOC-201 (Hemopure®, Hemoglobin gutamer-250, bovine), a bovine hemoglobin based blood substitute. Transfusion 42:S49–030I
go back to reference Winslow RM (2003) Current status of blood substitute research: towards a new paradigm. J Intern Med 253:508–517CrossRef Winslow RM (2003) Current status of blood substitute research: towards a new paradigm. J Intern Med 253:508–517CrossRef
go back to reference Wong NS, Chan TM (2007) Polyhemoglobin-fibrinogen: a novel oxygen carrier with platelet-like properties in a hemodiluted setting. Artif Cell Blood Substit Immobil Biotecnol 35(5):481–489CrossRef Wong NS, Chan TM (2007) Polyhemoglobin-fibrinogen: a novel oxygen carrier with platelet-like properties in a hemodiluted setting. Artif Cell Blood Substit Immobil Biotecnol 35(5):481–489CrossRef
go back to reference Zhang N, Jia Y, Chen G, Cabrales P, Palmer AF (2011) Tissue Eng Part A 17:927–940CrossRef Zhang N, Jia Y, Chen G, Cabrales P, Palmer AF (2011) Tissue Eng Part A 17:927–940CrossRef
Metadata
Title
Effects of Hemoglobin-Based Oxygen Carriers on Blood Coagulation
Authors
Jonathan S. Jahr
Molly Chung
Afsaneh Anvarhosseini
Hae Won Kim
Copyright Year
2013
Publisher
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-642-40717-8_34

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