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26-10-2021 | Original Research

Electrically controlled transdermal ibuprofen delivery consisting of pectin-bacterial cellulose/polypyrrole hydrogel composites

Authors: Nattinee Krathumkhet, Toyoko Imae, Nophawan Paradee

Published in: Cellulose | Issue 18/2021

Abstract

Pectin/bacteria cellulose (BC) hydrogel composites with various BC contents have been fabricated for the purpose of electrically controlled transdermal drug delivery. A conductive polymer, polypyrrole, was successfully incorporated into the pectin/BC hydrogel composite as a host of drug encapsulation for controlled release under applied electric field. Ibuprofen as a model drug was studied for its release behavior based on the effects of matrix composition, pH stimulation, matrix mesh size, and applied electrical potential by using a modified Franz diffusion cell. The drug release was optimized at 30 wt% BC and increased with applying electrical potential. The highest amount of drug release was 78% which was obtained on a drug-loaded polypyrrole-incorporated composite under applied electrical potential at 7 V. The hydrogel composites also presented the remarkable benefit of antibacterial activity for gram-positive bacteria. Thus, the hydrogel composites are valuable alternative materials for transdermal drug delivery.

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Title: Electrically controlled transdermal ibuprofen delivery consisting of pectin-bacterial cellulose/polypyrrole hydrogel composites
Authors: Nattinee Krathumkhet
Toyoko Imae
Nophawan Paradee
Publication date: 26-10-2021
Publisher: Springer Netherlands
Published in: Cellulose / Issue 18/2021
Print ISSN: 0969-0239
Electronic ISSN: 1572-882X
DOI: https://doi.org/10.1007/s10570-021-04259-x

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