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Journal of Materials Science
Published in: Journal of Materials Science 15/2018

25-04-2018 | Biomaterials

Electrospun sandwich configuration nanofibers as transparent membranes for skin care drug delivery systems

Authors: Ke Ma, Yiping Qiu, Yaqin Fu, Qing-Qing Ni

Published in: Journal of Materials Science | Issue 15/2018

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Abstract

The development of biocompatible nanocomposites for biomedical applications such as drug release has attracted increasing attention in recent years. In this work, electrospun membranes composed of polycaprolactone (PCL) and shellac were fabricated because PCL has favorable mechanical and biological properties, such as high biocompatibility and biodegradability. Meanwhile, shellac is biocompatible and non-toxic; as a result, the fabricated membranes are attractive for controlled drug delivery. Here, PCL/shellac/PCL nanofiber membranes were treated by ethanol vapor to improve their properties for use in drug delivery applications. Salicylic acid was loaded in the drug delivery system as a model drug, and three PCL/shellac/PCL membrane configurations were investigated. Ethanol vapor treatment increased the tensile strength, flexibility, and transparency of the membranes. Both the tensile strength and drug release properties of the membranes strongly depended on the ratio of PCL to shellac.
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Appendix
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Metadata
Title
Electrospun sandwich configuration nanofibers as transparent membranes for skin care drug delivery systems
Authors
Ke Ma
Yiping Qiu
Yaqin Fu
Qing-Qing Ni
Publication date
25-04-2018
Publisher
Springer US
Published in
Journal of Materials Science / Issue 15/2018
Print ISSN: 0022-2461
Electronic ISSN: 1573-4803
DOI
https://doi.org/10.1007/s10853-018-2241-4

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