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28-01-2021 | Original Research

Enhancing magnetic resonance imaging of bio-based nano-contrast via anchoring manganese on rod-shaped cellulose nanocrystals

Authors: Yang Shen, Xin Li, Yu Lan, Menghang Zu, Xiaoming Liu, Haitao Huang, Na Zhou, Ran Duan, Lin Gan, Jin Huang

Published in: Cellulose | Issue 5/2021

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Abstract

Manganese-based nano materials used to enhance nano-contrasts in magnetic resonance imaging have low toxicity but suffer from a weak contrast imaging effect due to their low longitudinal relaxivity (r₁). Moreover, the nanoparticle contrasts of manganese salt probably release manganese ions into the patient body during and after imaging process, causing potential toxicity problems. Thus, we took advantage of rod-shaped cellulose nanocrystals (CNCs) functionalized by diethylenetriamine pentaacetic dianhydride (coded as DCNCs) to anchor Mn²⁺ and improve its r₁ for biocompatibility, highly chemical activity, and high specific area. Theoretical analysis indicated that the r₁ could increase with the anchoring rate of Mn²⁺ on rod-shaped particles, and the large number of hydroxyl groups on CNCs made them able to carry as much as 5.9 mmol·g⁻¹ of Mn²⁺. Then, we found the r₁ increased linearly as the anchoring degree increased, up to 57.71 mM⁻¹·s⁻¹. The obtained DCNCs anchoring Mn²⁺ (Mn²⁺@DCNCs) nano-contrast showed low toxicity on RAW 264.7 and HUVEC, where the viability of the two cells was higher than 80%. Therefore, such a high r₁ Mn²⁺-based material presents great advantage of commercial manganese and gadolinium contrasts, making the Mn²⁺@DCNCs of potential on diagnosing tumors and drug release.

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Title: Enhancing magnetic resonance imaging of bio-based nano-contrast via anchoring manganese on rod-shaped cellulose nanocrystals
Authors: Yang Shen
Xin Li
Yu Lan
Menghang Zu
Xiaoming Liu
Haitao Huang
Na Zhou
Ran Duan
Lin Gan
Jin Huang
Publication date: 28-01-2021
Publisher: Springer Netherlands
Published in: Cellulose / Issue 5/2021
Print ISSN: 0969-0239
Electronic ISSN: 1572-882X
DOI: https://doi.org/10.1007/s10570-021-03693-1

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