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Aliphatic [18F]Fluorination Chemistry for Positron Emission Tomography Read chapter Read first chapter

2020 | OriginalPaper | Chapter

Et3N·3HF Complex Fluorination for Preparing Alkyl Fluorides

Author : Günter Haufe

Published in: Fluorination

Publisher: Springer Singapore

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Fluorinated organic compounds, both analogues of natural products and synthetic materials, gain enormous interest by organic and medicinal chemists, biochemists, material scientists, and others because of its unique chemical properties and biological activity. Consequently, there is a continuously growing demand of methods to synthesize such compounds. Although plenty of methods to introduce fluorine and fluorinated groups into organic compounds do exist, not all used reagents can be handled easily and safely in ordinary organic chemistry laboratories. A frequently used fluorination reagent is the triethylamine trihydrofluoride complex, Et3N·3HF [triethylamine tris(hydrogenfluoride)] as a source of nucleophilic fluoride [1‐4]. …

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previous chapter Electrochemical Fluorination for Preparing Aryl Fluorides
next chapter Fluolead (Ar-SF3) Deoxofluorination
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Metadata
Title
Et3N·3HF Complex Fluorination for Preparing Alkyl Fluorides
Author
Günter Haufe
Copyright Year
2020
Publisher
Springer Singapore
Book
Fluorination

Print ISBN: 978-981-10-3895-2

Electronic ISBN: 978-981-10-3896-9

Copyright Year: 2020

DOI
https://doi.org/10.1007/978-981-10-3896-9_26

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