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Synthesis of N-Linked Glycopeptides Using Convergent Enzymatic Glycosylation Combined with SPPS Read chapter Read first chapter

2018 | OriginalPaper | Chapter

Example of Sacrificial Unit Using Two Different Click Reactions in Coupling and Decoupling (CAD) Chemistry

Authors : Roman Bielski, Zbigniew J. Witczak, Donald Mencer

Published in: Coupling and Decoupling of Diverse Molecular Units in Glycosciences

Publisher: Springer International Publishing

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Abstract

An example of a specific coupling and decoupling (CAD) chemistry is described. It takes advantage of propargyl acrylate as a sacrificial unit (SU). The addition of a selected compound representing a molecular unit equipped with an azide functionality to the terminal triple bond of the SU and another compound acting as a molecular unit equipped with a thiol functionality to the conjugated double bond of the SU proceeded at very good yields. The construct containing two molecular units can be decoupled using a few different reactions and the decoupling can take place at two positions.

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Metadata
Title
Example of Sacrificial Unit Using Two Different Click Reactions in Coupling and Decoupling (CAD) Chemistry
Authors
Roman Bielski
Zbigniew J. Witczak
Donald Mencer
Copyright Year
2018
Book
Coupling and Decoupling of Diverse Molecular Units in Glycosciences

Print ISBN: 978-3-319-65586-4

Electronic ISBN: 978-3-319-65587-1

Copyright Year: 2018

DOI
https://doi.org/10.1007/978-3-319-65587-1_13