2013 | OriginalPaper | Chapter
Exercise Induced Inter-individual Variation of Right Ventricular Pressures: Simulations Using a Modular Model of the Cardiovascular System
Authors : Catalina Tobon-Gomez, Georgina Palau-Caballero, Marta Sitges, Bart H. Bijnens
Published in: Statistical Atlases and Computational Models of the Heart. Imaging and Modelling Challenges
Publisher: Springer Berlin Heidelberg
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In recent years, the response of, especially, the right ventricle to intense exercise has gained increased interest. In this study, we use the CircAdapt model to evaluate the influence of inter-individual variation of pulmonary vascular resistance during exercise on cardiovascular hemodynamics. We modeled pulmonary vascular resistance as a nonlinear resistive module in which the resistance increases proportionally to stroke volume. We modeled inter-individual variation following normal random distributions. To evaluate the hemodynamic response to exercise, we computed pulmonary artery systolic pressure and end-systolic wall stress. With our modeling strategy, we were able to reproduce the phenomena observed clinically.