Skip to main content
Top
Published in: Journal of Materials Science 4/2019

22-10-2018 | Materials for life sciences

Fabricated porous silk fibroin particles for pH-responsive drug delivery and targeting of tumor cells

Authors: Ning Sun, Rong Lei, Jianghui Xu, Subhas C. Kundu, Yurong Cai, Juming Yao, Qingqing Ni

Published in: Journal of Materials Science | Issue 4/2019

Log in

Activate our intelligent search to find suitable subject content or patents.

search-config
loading …

Abstract

To improve the roles of tumor drug, porous silk fibroin particles have been designed as drug carriers. Doxorubicin (DOX) is encapsulated during the fabrication process of the silk fibroin particles to form DOX loaded silk fibroin particles (SFPs-DOX). Folic acid (FA) is covalently grafted to the surface of the silk fibroin particles (FA-SFPs-DOX) as a target group to the folate receptor of tumor cells. The experimental results showed that under the conditions of low pH, high ionic strength and high enzyme concentration, the release of loaded drugs in particles has stimulus response under various conditions. The synthesized silk fibroin particles have good biocompatibility. The specific binding of fibroin particles to folate receptors provides the particles to with target functions to the tumor cells. The job develops potential application of silk fibroin particles as smart drug carriers for the targeted therapy of tumor.

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Appendix
Available only for authorised users
Literature
1.
go back to reference Such GK, Yan Y, Johnston APR, Gunawan ST, Caruso F (2015) Interfacing materials science and biology for drug carrier design. Adv Mater 27:2278–2297CrossRef Such GK, Yan Y, Johnston APR, Gunawan ST, Caruso F (2015) Interfacing materials science and biology for drug carrier design. Adv Mater 27:2278–2297CrossRef
2.
go back to reference Min KH, Park K, Kim YS, Bae SM, Lee S, Jo HG, Park RW, Kim IS, Jeong SY, Kim K, Kwon IC (2008) Hydrophobically modified glycol chitosan nanoparticles-encapsulated camptothecin enhance the drug stability and tumor targeting in cancer therapy. J Control Release 127:208–218CrossRef Min KH, Park K, Kim YS, Bae SM, Lee S, Jo HG, Park RW, Kim IS, Jeong SY, Kim K, Kwon IC (2008) Hydrophobically modified glycol chitosan nanoparticles-encapsulated camptothecin enhance the drug stability and tumor targeting in cancer therapy. J Control Release 127:208–218CrossRef
3.
go back to reference Du JZ, Du XJ, Mao CQ, Wang J (2011) Tailor-made dual pH-sensitive polymer-doxorubicin nanoparticles for efficient anticancer drug delivery. J Am Chem Soc 133:17560–17563CrossRef Du JZ, Du XJ, Mao CQ, Wang J (2011) Tailor-made dual pH-sensitive polymer-doxorubicin nanoparticles for efficient anticancer drug delivery. J Am Chem Soc 133:17560–17563CrossRef
4.
go back to reference Shi Y, Wang M, Ma CB, Yu GH (2015) A conductive self-healing hybrid gel enabled by metal-ligand supramolecule and nanostructured conductive polymer. Nano Lett 15:6276–6281CrossRef Shi Y, Wang M, Ma CB, Yu GH (2015) A conductive self-healing hybrid gel enabled by metal-ligand supramolecule and nanostructured conductive polymer. Nano Lett 15:6276–6281CrossRef
5.
go back to reference Pérez-Herrero E, Fernández-Medarde A (2015) Advanced targeted therapies in cancer: drug nanocarriers, the future of chemotherapy. Eur J Pharm 93:52–79CrossRef Pérez-Herrero E, Fernández-Medarde A (2015) Advanced targeted therapies in cancer: drug nanocarriers, the future of chemotherapy. Eur J Pharm 93:52–79CrossRef
6.
go back to reference Chang BS, Sha XY, Guo J, Jiao YF, Wang CC, Yang WL (2011) Thermo and pH dual responsive, polymer shell coated, magnetic mesoporous silica nanoparticles for controlled drug release. J Mater Chem 21:9239–9247CrossRef Chang BS, Sha XY, Guo J, Jiao YF, Wang CC, Yang WL (2011) Thermo and pH dual responsive, polymer shell coated, magnetic mesoporous silica nanoparticles for controlled drug release. J Mater Chem 21:9239–9247CrossRef
7.
go back to reference Horan RL, Antle K, Collette AL, Wang YZ, Huang J, Moreau JE, Volloch V, Kaplan DL, Altman GH (2005) In vitro degradation of silk fibroin. Biomaterials 26:3385–3393CrossRef Horan RL, Antle K, Collette AL, Wang YZ, Huang J, Moreau JE, Volloch V, Kaplan DL, Altman GH (2005) In vitro degradation of silk fibroin. Biomaterials 26:3385–3393CrossRef
8.
go back to reference Shi LB, Cai HX, Chen LK, Wu Y, Zhu SA, Gong XN, Xia YX, Ouyang HW, Zou XH (2014) Tissue engineered bulking agent with adipose-derived stem cells and silk fibroin microspheres for the treatment of intrinsic urethral sphincter deficiency. Biomaterials 35:1519–1530CrossRef Shi LB, Cai HX, Chen LK, Wu Y, Zhu SA, Gong XN, Xia YX, Ouyang HW, Zou XH (2014) Tissue engineered bulking agent with adipose-derived stem cells and silk fibroin microspheres for the treatment of intrinsic urethral sphincter deficiency. Biomaterials 35:1519–1530CrossRef
9.
go back to reference Wongpinyochit T, Uhlmann P, Urquhart AJ, Seib FP (2015) PEGylated silk nanoparticles for anticancer drug delivery. Biomacromol 16:3712–3722CrossRef Wongpinyochit T, Uhlmann P, Urquhart AJ, Seib FP (2015) PEGylated silk nanoparticles for anticancer drug delivery. Biomacromol 16:3712–3722CrossRef
10.
go back to reference Brown JE, Partlow BP, Berman AM, House MD, Kaplan DL (2016) Injectable silk-based biomaterials for cervical tissue augmentation: an in vitro study. Am J Obstet Gynecol 214:118e1–118e9CrossRef Brown JE, Partlow BP, Berman AM, House MD, Kaplan DL (2016) Injectable silk-based biomaterials for cervical tissue augmentation: an in vitro study. Am J Obstet Gynecol 214:118e1–118e9CrossRef
11.
go back to reference Shi JJ, Votruba AR, Farokhzad OC, Langer R (2010) Nanotechnology in drug delivery and tissue engineering: from discovery to applications. Nano Lett 10:3223–3230CrossRef Shi JJ, Votruba AR, Farokhzad OC, Langer R (2010) Nanotechnology in drug delivery and tissue engineering: from discovery to applications. Nano Lett 10:3223–3230CrossRef
12.
go back to reference Shchepelina O, Drachuk I, Gupta MK, Lin J, Tsukruk VV (2011) Silk-on-silk layer-by-layer microcapsules. Adv Mater 23:4655–4660CrossRef Shchepelina O, Drachuk I, Gupta MK, Lin J, Tsukruk VV (2011) Silk-on-silk layer-by-layer microcapsules. Adv Mater 23:4655–4660CrossRef
13.
go back to reference Wang Q, Jian MQ, Wang CY, Zhang YY (2017) Carbonized silk nanofiber membrane for transparent and sensitive electronic skin. Adv Func Mater 27:1605657–1605666CrossRef Wang Q, Jian MQ, Wang CY, Zhang YY (2017) Carbonized silk nanofiber membrane for transparent and sensitive electronic skin. Adv Func Mater 27:1605657–1605666CrossRef
14.
go back to reference Subia B, Dey T, Sharma S, Kundu SC (2015) Target specific delivery of anticancer drug in silk fibroin-based 3D distribution model of bone-breast cancer cells. ACS Appl Mater Interfaces 7:2269–2279CrossRef Subia B, Dey T, Sharma S, Kundu SC (2015) Target specific delivery of anticancer drug in silk fibroin-based 3D distribution model of bone-breast cancer cells. ACS Appl Mater Interfaces 7:2269–2279CrossRef
15.
go back to reference Vepari C, Kaplan DL (2007) Silk as a biomaterial. Prog Polym Sci 32:991–1007CrossRef Vepari C, Kaplan DL (2007) Silk as a biomaterial. Prog Polym Sci 32:991–1007CrossRef
16.
go back to reference Tian Y, Jiang XJ, Chen X, Shao ZZ, Yang WL (2014) Doxorubicin-loaded magnetic silk fibroin nanoparticles for targeted therapy of multidrug-resistant cancer. Adv Mater 26:7393–7398CrossRef Tian Y, Jiang XJ, Chen X, Shao ZZ, Yang WL (2014) Doxorubicin-loaded magnetic silk fibroin nanoparticles for targeted therapy of multidrug-resistant cancer. Adv Mater 26:7393–7398CrossRef
17.
go back to reference Yang MY, Zhou GS, Shuai YJ, Wang J, Zhu LJ, Mao CB (2014) Tuning molecular weights of Bombyx mori (B. mori) silk sericin to modify its assembly structures and materials formation. ACS Appl Mater Interfaces 16:13782–13789CrossRef Yang MY, Zhou GS, Shuai YJ, Wang J, Zhu LJ, Mao CB (2014) Tuning molecular weights of Bombyx mori (B. mori) silk sericin to modify its assembly structures and materials formation. ACS Appl Mater Interfaces 16:13782–13789CrossRef
18.
go back to reference Yang MY, Shuai YJ, Zhang C, Chen YY, Zhu LJ, Mao CB (2014) Biomimetic nucleation of hydroxyapatite crystals mediated by Antheraea pernyi (A. pernyi) silk sericin promotes osteogenic differentiation of human bone marrow derived mesenchymal stem cells. Biomacromol 15:1185–1193CrossRef Yang MY, Shuai YJ, Zhang C, Chen YY, Zhu LJ, Mao CB (2014) Biomimetic nucleation of hydroxyapatite crystals mediated by Antheraea pernyi (A. pernyi) silk sericin promotes osteogenic differentiation of human bone marrow derived mesenchymal stem cells. Biomacromol 15:1185–1193CrossRef
19.
go back to reference Wu J, Liu L, Cai YR, Yao JM (2013) Recent advances of calcium phosphate nanoparticles for controlled drug delivery. Mini Rev Med Chem 13:1501–1507CrossRef Wu J, Liu L, Cai YR, Yao JM (2013) Recent advances of calcium phosphate nanoparticles for controlled drug delivery. Mini Rev Med Chem 13:1501–1507CrossRef
20.
go back to reference Xu S, Olenyuk BZ, Okamoto CT, Hamm-Alvarez SF (2013) Targeting receptor-mediated endocytotic pathways with nanoparticles: rationale and advance. Adv Drug Deliv Rev 65:121–138CrossRef Xu S, Olenyuk BZ, Okamoto CT, Hamm-Alvarez SF (2013) Targeting receptor-mediated endocytotic pathways with nanoparticles: rationale and advance. Adv Drug Deliv Rev 65:121–138CrossRef
21.
go back to reference Guan XW, Li YH, Jiao ZX, Chen J, Guo ZP, Tian HY, Chen XS (2013) A pH-sensitive charge-conversion system for doxorubicin delivery. Acta Biomater 9:7672–7678CrossRef Guan XW, Li YH, Jiao ZX, Chen J, Guo ZP, Tian HY, Chen XS (2013) A pH-sensitive charge-conversion system for doxorubicin delivery. Acta Biomater 9:7672–7678CrossRef
22.
go back to reference Huang L, Tao KX, Liu J, Qi C, Xu LM, Chang PP, Gao JB, Shuai XM, Wang GB, Wang Z, Wang L (2016) Design and fabrication of multifunctional sericin nanoparticles for tumor targeting and ph-responsive subcellular delivery of cancer chemotherapy drugs. ACS Appl Mater Interfaces 8:6577–6585CrossRef Huang L, Tao KX, Liu J, Qi C, Xu LM, Chang PP, Gao JB, Shuai XM, Wang GB, Wang Z, Wang L (2016) Design and fabrication of multifunctional sericin nanoparticles for tumor targeting and ph-responsive subcellular delivery of cancer chemotherapy drugs. ACS Appl Mater Interfaces 8:6577–6585CrossRef
23.
go back to reference Subia B, Kundu SC (2013) Drug loading and release on tumor cells using silk fibroin-albumin nanoparticles as carriers. Nanotechnology 24:035103CrossRef Subia B, Kundu SC (2013) Drug loading and release on tumor cells using silk fibroin-albumin nanoparticles as carriers. Nanotechnology 24:035103CrossRef
24.
go back to reference Lammel AS, Hu X, Park SH, Kaplan DL, Scheibel TR (2010) Controlling silk fibroin particle features for drug delivery. Biomaterials 31:4583–4591CrossRef Lammel AS, Hu X, Park SH, Kaplan DL, Scheibel TR (2010) Controlling silk fibroin particle features for drug delivery. Biomaterials 31:4583–4591CrossRef
25.
go back to reference El-Gogary RI, Rubio N, Wang JT, Al-Jamal WT, Bourgognon M, Kafa H, Naeem M, Klippstein R, Abbate V, Leroux F, Bals S, Tendeloo GV, Kamel AO, Awad GAS, Mortada ND, Al-Jamal KT (2014) Polyethylene glycol conjugated polymeric nanocapsules for targeted delivery of quercetin to folate-expressing cancer cells in vitro and in vivo. ACS Nano 8:1384–1401CrossRef El-Gogary RI, Rubio N, Wang JT, Al-Jamal WT, Bourgognon M, Kafa H, Naeem M, Klippstein R, Abbate V, Leroux F, Bals S, Tendeloo GV, Kamel AO, Awad GAS, Mortada ND, Al-Jamal KT (2014) Polyethylene glycol conjugated polymeric nanocapsules for targeted delivery of quercetin to folate-expressing cancer cells in vitro and in vivo. ACS Nano 8:1384–1401CrossRef
26.
go back to reference Banerjee SS, Chen DH (2008) Multifunctional pH-sensitive magnetic nanoparticles for simultaneous imaging, sensing and targeted intracellular anticancer drug delivery. Nanotechnology 19:505104CrossRef Banerjee SS, Chen DH (2008) Multifunctional pH-sensitive magnetic nanoparticles for simultaneous imaging, sensing and targeted intracellular anticancer drug delivery. Nanotechnology 19:505104CrossRef
27.
go back to reference Shi JJ, Zhang HL, Wang L, Li LL, Wang HH, Wang ZZ, Li Z, Chen CQ, Hou L, Zhang CF, Zhang ZZ (2013) PEI-derivatized fullerene drug delivery using folate as a homing device targeting to tumor. Biomaterials 34:251–261CrossRef Shi JJ, Zhang HL, Wang L, Li LL, Wang HH, Wang ZZ, Li Z, Chen CQ, Hou L, Zhang CF, Zhang ZZ (2013) PEI-derivatized fullerene drug delivery using folate as a homing device targeting to tumor. Biomaterials 34:251–261CrossRef
28.
go back to reference Chen FH, Zhang LM, Chen QT, Zhang Y, Zhang ZJ (2010) Synthesis of a novel magnetic drug delivery system composed of doxorubicin-conjugated Fe3O4 nanoparticle cores and a PEG-functionalized porous silica shell. Chem Commun 46:8633–8635CrossRef Chen FH, Zhang LM, Chen QT, Zhang Y, Zhang ZJ (2010) Synthesis of a novel magnetic drug delivery system composed of doxorubicin-conjugated Fe3O4 nanoparticle cores and a PEG-functionalized porous silica shell. Chem Commun 46:8633–8635CrossRef
29.
go back to reference Seib FP, Kaplan DL (2012) Doxorubicin-loaded silk films: drug-silk interactions and in vivo performance in human orthotopic breast cancer. Biomaterials 33:8442–8450CrossRef Seib FP, Kaplan DL (2012) Doxorubicin-loaded silk films: drug-silk interactions and in vivo performance in human orthotopic breast cancer. Biomaterials 33:8442–8450CrossRef
30.
go back to reference Lu YJ, Low PS (2012) Folate-mediated delivery of macromolecular anticancer therapeutic agents. Adv Drug Deliv Rev 64:342–352CrossRef Lu YJ, Low PS (2012) Folate-mediated delivery of macromolecular anticancer therapeutic agents. Adv Drug Deliv Rev 64:342–352CrossRef
31.
go back to reference Liu JQ, Cui L, Losic D (2013) Graphene and graphene oxide as new nanocarriers for drug delivery applications. Acta Biomater 9:9243–9257CrossRef Liu JQ, Cui L, Losic D (2013) Graphene and graphene oxide as new nanocarriers for drug delivery applications. Acta Biomater 9:9243–9257CrossRef
32.
go back to reference Guo X, Shi CL, Yang G, Wang J, Cai ZH, Zhou SB (2014) Dual-responsive polymer micelles for target-cell-specific anticancer drug delivery. Chem Mater 26:4405–4418CrossRef Guo X, Shi CL, Yang G, Wang J, Cai ZH, Zhou SB (2014) Dual-responsive polymer micelles for target-cell-specific anticancer drug delivery. Chem Mater 26:4405–4418CrossRef
33.
go back to reference Ma NX, Liu J, He WX, Li ZH, Luan YX, Song YM, Garg S (2017) Folic acid-grafted bovine serum albumin decorated graphene oxide: an efficient drug carrier for targeted cancer therapy. J Colloid Interface Sci 490:598–607CrossRef Ma NX, Liu J, He WX, Li ZH, Luan YX, Song YM, Garg S (2017) Folic acid-grafted bovine serum albumin decorated graphene oxide: an efficient drug carrier for targeted cancer therapy. J Colloid Interface Sci 490:598–607CrossRef
34.
go back to reference Shuai XT, Ai H, Nasongkla N, Gao JM (2004) cRGD-functionalized polymer micelles for targeted doxorubicin delivery. Angew Chem Int Ed Engl 43:6323–6327CrossRef Shuai XT, Ai H, Nasongkla N, Gao JM (2004) cRGD-functionalized polymer micelles for targeted doxorubicin delivery. Angew Chem Int Ed Engl 43:6323–6327CrossRef
Metadata
Title
Fabricated porous silk fibroin particles for pH-responsive drug delivery and targeting of tumor cells
Authors
Ning Sun
Rong Lei
Jianghui Xu
Subhas C. Kundu
Yurong Cai
Juming Yao
Qingqing Ni
Publication date
22-10-2018
Publisher
Springer US
Published in
Journal of Materials Science / Issue 4/2019
Print ISSN: 0022-2461
Electronic ISSN: 1573-4803
DOI
https://doi.org/10.1007/s10853-018-3022-9

Other articles of this Issue 4/2019

Journal of Materials Science 4/2019 Go to the issue

Premium Partners