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Microsystem Technologies

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14-02-2017 | Technical Paper

Fabrication and hemocompatibility of carboxy-chitosan stabilized magnetite nanoparticles

Authors: Md. Abdur Rahman, Bungo Ochiai

Published in: Microsystem Technologies | Issue 1/2018

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Abstract

This paper describes fabrication of a new hemocompatible, magnetic nanoparticles based on magnetite and naturally occurring chitosan, potentially applicable as biomaterials to nanobiomedicine. We fabricated carboxy-functionalized magnetite–chitosan (Fe₃O₄–CS–BTCDA) nanocomposite particles by a simple two-stage protocol. Magnetite–chitosan (Fe₃O₄–CS) nanocomposite particles were first prepared via in situ chemical coprecipitation reactions using Fe²⁺ and Fe³⁺ salts in an alkaline aqueous solution of CS. Fe₃O₄–CS nanocomposite particles were then reacted with butanetetracarboxylic dianhydride (BTCDA) to obtain the Fe₃O₄–CS–BTCDA nanocomposite particles dispersible under physiological conditions. The obtained nanoparticles are superparamagnetic. The hemolytic activity of the Fe₃O₄–CS–BTCDA nanocomposite particles is very low and essential for practical bio-related applications.

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Title: Fabrication and hemocompatibility of carboxy-chitosan stabilized magnetite nanoparticles
Authors: Md. Abdur Rahman
Bungo Ochiai
Publication date: 14-02-2017
Publisher: Springer Berlin Heidelberg
Published in: Microsystem Technologies / Issue 1/2018
Print ISSN: 0946-7076
Electronic ISSN: 1432-1858
DOI: https://doi.org/10.1007/s00542-017-3318-8

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