2006 | OriginalPaper | Chapter
Fast Protein Structure Alignment Algorithm Based on Local Geometric Similarity
Authors : Chan-Yong Park, Sung-Hee Park, Dae-Hee Kim, Soo-Jun Park, Man-Kyu Sung, Hong-Ro Lee, Jung-Sub Shin, Chi-Jung Hwang
Published in: MICAI 2006: Advances in Artificial Intelligence
Publisher: Springer Berlin Heidelberg
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This paper proposes a novel fast protein structure alignment algorithm and its application. Because it is known that the functions of protein are derived from its structure, the method of measuring the structural similarities between two proteins can be used to infer their functional closeness. In this paper, we propose a 3D chain code representation for fast measuring the local geometric similarity of protein and introduce a backtracking algorithm for joining a similar local substructure efficiently. A 3D chain code, which is a sequence of the directional vectors between the atoms in a protein, represents a local similarity of protein. After constructing a pair of similar substructures by referencing local similarity, we perform the protein alignment by joining the similar substructure pair through a backtracking algorithm. This method has particular advantages over all previous approaches; our 3D chain code representation is more intuitive and our experiments prove that the backtracking algorithm is faster than dynamic programming in general case. We have designed and implemented a protein structure alignment system based on our protein visualization software (MoleView). These experiments show rapid alignment with precise results.