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2018 | OriginalPaper | Chapter

Flow Chemistry as a Drug Discovery Tool: A Medicinal Chemistry Perspective

Authors : Andrew R. Bogdan, Michael G. Organ

Published in: Flow Chemistry for the Synthesis of Heterocycles

Publisher: Springer International Publishing

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Abstract

The applications of flow chemistry in a drug discovery environment are discussed within. The development of integrated synthesis–bioassay platforms is discussed in the context of enabling medicinal chemistry programs, as is the use of flow chemistry to facilitate intermediate scale-up in a lead optimization setting. Emerging chemical technologies are also discussed, highlighting the use of high temperatures, hazardous gases, and photochemistry in flow to support medicinal chemistry efforts.

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Title: Flow Chemistry as a Drug Discovery Tool: A Medicinal Chemistry Perspective
Authors: Andrew R. Bogdan
Michael G. Organ
Publisher: Springer International Publishing
Book: Flow Chemistry for the Synthesis of Heterocycles
Print ISBN: 978-3-319-94327-5

Electronic ISBN: 978-3-319-94328-2

Copyright Year: 2018
DOI: https://doi.org/10.1007/7081_2018_24