2006 | OriginalPaper | Chapter
From Kinetics to Structure: High Resolution Molecular Microscopy
Author : Jeremy J. Ramsden
Published in: Proteins at Solid-Liquid Interfaces
Publisher: Springer Berlin Heidelberg
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Existing methods of protein structural determination either present a static picture under unnatural conditions or impose a considerable perturbation on the molecule during measurement. This chapter introduces high resolution optical waveguide lightmode spectroscopy (OWLS) as an alternative non-imaging technique of great power and versatility enabling the structure and dynamics of proteins at interfaces to be characterized with unprecedented richness and precision.