Skip to main content
Top

2009 | OriginalPaper | Chapter

6. Fructan Prebiotics Derived from Inulin

Author : Douwina Bosscher

Published in: Prebiotics and Probiotics Science and Technology

Publisher: Springer New York

Activate our intelligent search to find suitable subject content or patents.

search-config
loading …

Abstract

Inulin, as well as the shorter form oligofructose, is a nondigestible carbohydrate (fructan) that has been part of the daily food of mankind for centuries. Inulin-type fructans naturally occur in many edible plants as storage carbohydrates. They are present in leek, onion, garlic, wheat, chicory, artichoke, and banana. It is estimated that an average North American consumes about 1–4 g/day of inulin or oligofructose. In Western Europe, the average intake varies between 3 and 10 g/day. Occasionally, people can have higher intakes, e.g., after consuming a bowl of French onion soup, salsify dish, etc., and intakes can then exceed easily 10 g. This illustrates that via the normal diet some, and at certain times, all populations consume relatively high quantities of inulin-type fructans. It also follows that wheat, onion, and banana, and to a lesser extend garlic are the most important sources of inulin-type fructans in the diet. Although inulin-type fructans are nutritive substances and part of our daily diet, these compounds are currently not taken up in food composition tables.

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Literature
go back to reference Abrams SA, Griffin IJ, Hawthorne KM, Ellis KJ (2007) Effect of prebiotic supplementation and calcium intake on body mass index. J Pediatr 151:293–298CrossRef Abrams SA, Griffin IJ, Hawthorne KM, Ellis KJ (2007) Effect of prebiotic supplementation and calcium intake on body mass index. J Pediatr 151:293–298CrossRef
go back to reference Abrams SA, Griffin IJ, Hawthorne KM, Liang L, Gunn SK, Darlington G, Ellis KJ (2005) A combination of prebiotic short- and long-chain inulin-type fructans enhances calcium absorption and bone mineralization in young adolescents. Am J Clin Nutr 82:471–476 Abrams SA, Griffin IJ, Hawthorne KM, Liang L, Gunn SK, Darlington G, Ellis KJ (2005) A combination of prebiotic short- and long-chain inulin-type fructans enhances calcium absorption and bone mineralization in young adolescents. Am J Clin Nutr 82:471–476
go back to reference Ananta E, Birkeland S-E, Corcoran B, Fitzgerald G, Hinz S, Klijn A, Mättö J, mercenier A, Nilsson U, Nyman M, O’Sullivan E, Parche S, Rautonen N, Ross RP, Saarela M, Stanton C, Stahl U, Suomalainen T, Vincken J-P, Virkajärvi I, Voragen F, Wesenfeld J, Wouters R, Knorr D (2004) Processing effects on the nutritional advancement of probiotics and prebiotics. Microb Ecol Health Dis 16:113–124CrossRef Ananta E, Birkeland S-E, Corcoran B, Fitzgerald G, Hinz S, Klijn A, Mättö J, mercenier A, Nilsson U, Nyman M, O’Sullivan E, Parche S, Rautonen N, Ross RP, Saarela M, Stanton C, Stahl U, Suomalainen T, Vincken J-P, Virkajärvi I, Voragen F, Wesenfeld J, Wouters R, Knorr D (2004) Processing effects on the nutritional advancement of probiotics and prebiotics. Microb Ecol Health Dis 16:113–124CrossRef
go back to reference Archer BJ, Johnson SK, Devereux HM, Baxter AL (2004) Effect of fat replacement by inulin or lupin-kernel on sausage patty acceptability, post-meal perceptions of satiety and food intake in men. Br J Nutr 91:591–599CrossRef Archer BJ, Johnson SK, Devereux HM, Baxter AL (2004) Effect of fat replacement by inulin or lupin-kernel on sausage patty acceptability, post-meal perceptions of satiety and food intake in men. Br J Nutr 91:591–599CrossRef
go back to reference Bartosch S, Woodmansey EJ, Paterson JCM, McMurdo ET, Macfarlane GT (2005) Microbiological effects of consuming a synbiotic containing Bifidobacterium bifidum, Bifidobacterium lactis, and oligofructose in elderly persons, determined by real-time polymerase chain reaction and counting of viable bacteria. CID 40:28–37CrossRef Bartosch S, Woodmansey EJ, Paterson JCM, McMurdo ET, Macfarlane GT (2005) Microbiological effects of consuming a synbiotic containing Bifidobacterium bifidum, Bifidobacterium lactis, and oligofructose in elderly persons, determined by real-time polymerase chain reaction and counting of viable bacteria. CID 40:28–37CrossRef
go back to reference Belenguer A, Duncan SH, Calder AG, Holtrop G, Louis P, Lobley GE, Flint HJ (2006) Two routes of metabolic cross-feeding between Bifidobacterium adolescentis and butyrate-producing anaerobes from the human gut. Appl Environ Microbiol 72:3593–3599CrossRef Belenguer A, Duncan SH, Calder AG, Holtrop G, Louis P, Lobley GE, Flint HJ (2006) Two routes of metabolic cross-feeding between Bifidobacterium adolescentis and butyrate-producing anaerobes from the human gut. Appl Environ Microbiol 72:3593–3599CrossRef
go back to reference Benyacoub J, Rochat F, Saudan K-Y, Rochat I, Antille N, Cherbut C, von der Weid T, Schiffrin EJ, Blum S (2008) Feeding a diet containing a fructooligosaccharide mix can enhance Salmonella vaccine efficacy in mice. J Nutr 138:123–129 Benyacoub J, Rochat F, Saudan K-Y, Rochat I, Antille N, Cherbut C, von der Weid T, Schiffrin EJ, Blum S (2008) Feeding a diet containing a fructooligosaccharide mix can enhance Salmonella vaccine efficacy in mice. J Nutr 138:123–129
go back to reference Bosscher D, Van Loo J, Franck A (2006a) Inulin and oligofructose as prebiotics in the prevention of intestinal infections and diseases. Nutr Res Rev 19:216–226CrossRef Bosscher D, Van Loo J, Franck A (2006a) Inulin and oligofructose as prebiotics in the prevention of intestinal infections and diseases. Nutr Res Rev 19:216–226CrossRef
go back to reference Bosscher D, Van Loo J, Franck A (2006b) Inulin and oligofructose as functional ingredients to improve mineralization. Int Dairy J 16:1092–1097CrossRef Bosscher D, Van Loo J, Franck A (2006b) Inulin and oligofructose as functional ingredients to improve mineralization. Int Dairy J 16:1092–1097CrossRef
go back to reference Brighenti F, Casiraghi MC, Canzi E, Ferrari A (1999) Effect of consumption of a ready-to-eat breakfast cereal containing inulin on the intestinal milieu and blood lipids in healthy male volunteers. Eur J Clin Nutr 53:726–733CrossRef Brighenti F, Casiraghi MC, Canzi E, Ferrari A (1999) Effect of consumption of a ready-to-eat breakfast cereal containing inulin on the intestinal milieu and blood lipids in healthy male volunteers. Eur J Clin Nutr 53:726–733CrossRef
go back to reference Buddington KK, Donahoo JB, Buddington RK (2002) Dietary oligofructose and inulin protect mice from enteric and systemic pathogens and tumor inducers. J Nutr 132:472–477 Buddington KK, Donahoo JB, Buddington RK (2002) Dietary oligofructose and inulin protect mice from enteric and systemic pathogens and tumor inducers. J Nutr 132:472–477
go back to reference Bunout D, Barrera G, Hirsch S, Gattas V, Pia de la Maza M, Haschke F, Steenhout P, Klassen P, Hager C, Avendano M, Petermann M, Munoz C (2004) Effects of a nutritional supplement on the immune response and cytokine production in free-living Chilean elderly. J Parenter Enteral Nutr 28:348–354CrossRef Bunout D, Barrera G, Hirsch S, Gattas V, Pia de la Maza M, Haschke F, Steenhout P, Klassen P, Hager C, Avendano M, Petermann M, Munoz C (2004) Effects of a nutritional supplement on the immune response and cytokine production in free-living Chilean elderly. J Parenter Enteral Nutr 28:348–354CrossRef
go back to reference Butel M, Catala I, Waligora-Dupriet A, Taper H, Tessedre A, Durao J, Szylit O (2001) Protective effect of dietary oligofructose against cecitis induced by clostridia in gnotobiotic quails. Microb Ecol Health Dis 13:166–172CrossRef Butel M, Catala I, Waligora-Dupriet A, Taper H, Tessedre A, Durao J, Szylit O (2001) Protective effect of dietary oligofructose against cecitis induced by clostridia in gnotobiotic quails. Microb Ecol Health Dis 13:166–172CrossRef
go back to reference Butel MJ, Roland N, Hibert A, Popot F, Favre A, Tessedre AC, Bensaada M, Rimbault A, Szylit O (1998) Clostridial pathogenicity in experimental necrotising enterocolitis in gnotobiotic quails and protective role of bifidobacteria. J Med Microbiol 47(5):391–399CrossRef Butel MJ, Roland N, Hibert A, Popot F, Favre A, Tessedre AC, Bensaada M, Rimbault A, Szylit O (1998) Clostridial pathogenicity in experimental necrotising enterocolitis in gnotobiotic quails and protective role of bifidobacteria. J Med Microbiol 47(5):391–399CrossRef
go back to reference Cani P, Daubioul C, Reusens B, Remacle C, Catillon G, Delzenne N (2005b) Involvement of endogeneous glucagon-like peptide-1(7–36) amide on glycemia-lowering effect of oligofructose in streptozotocin-treated rats. J Endocrin 185:457–465CrossRef Cani P, Daubioul C, Reusens B, Remacle C, Catillon G, Delzenne N (2005b) Involvement of endogeneous glucagon-like peptide-1(7–36) amide on glycemia-lowering effect of oligofructose in streptozotocin-treated rats. J Endocrin 185:457–465CrossRef
go back to reference Cani P, Dewever C, Delzenne M (2004) Inulin-type fructans modulate gastrointestinal peptides involved in appetite regulation (glucagon-like peptide-1 and ghrelin) in rats. Br J Nutr 92:521–526CrossRef Cani P, Dewever C, Delzenne M (2004) Inulin-type fructans modulate gastrointestinal peptides involved in appetite regulation (glucagon-like peptide-1 and ghrelin) in rats. Br J Nutr 92:521–526CrossRef
go back to reference Cani PD, Hoste S, Guiot Y, Delzenne NM (2007a) Dietary non-digestible carbohydrates promote L-cell differentiation in the proximal colon of rats. Br J Nutr 98:32–37CrossRef Cani PD, Hoste S, Guiot Y, Delzenne NM (2007a) Dietary non-digestible carbohydrates promote L-cell differentiation in the proximal colon of rats. Br J Nutr 98:32–37CrossRef
go back to reference Cani P, Joly E, Hormans Y, Delzenne N (2006a) Oligofructose promotes satiety in healthy human: a pilot study. Eur J Clin Nutr 60:567–572CrossRef Cani P, Joly E, Hormans Y, Delzenne N (2006a) Oligofructose promotes satiety in healthy human: a pilot study. Eur J Clin Nutr 60:567–572CrossRef
go back to reference Cani P, Knauf C, Iglesias M, Drucker D, Delzenne N, Burcelin R (2006b) Improvement of glucose tolerance and hepatic insulin secretion by oligofructose requires a functional glucagon-like peptide 1 receptor. Diabetes 55:1484–1490CrossRef Cani P, Knauf C, Iglesias M, Drucker D, Delzenne N, Burcelin R (2006b) Improvement of glucose tolerance and hepatic insulin secretion by oligofructose requires a functional glucagon-like peptide 1 receptor. Diabetes 55:1484–1490CrossRef
go back to reference Cani PD, Neyrinck AM, Fava F, Knauf C, Burcelin RG, Tuohy KM, Gibson GR, Delzenne NM (2007b) Selective increases of bifidobacteria in gut microflora improve high-fat-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologica 50:2374–2383CrossRef Cani PD, Neyrinck AM, Fava F, Knauf C, Burcelin RG, Tuohy KM, Gibson GR, Delzenne NM (2007b) Selective increases of bifidobacteria in gut microflora improve high-fat-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologica 50:2374–2383CrossRef
go back to reference Cani P, Neyrinck A, Maton N, Delzenne N (2005a) Oligofructose promotes satiety in rats fed a high-fat diet: involvement of glucagon-like peptide-1. Obes Res 13:1000–1007CrossRef Cani P, Neyrinck A, Maton N, Delzenne N (2005a) Oligofructose promotes satiety in rats fed a high-fat diet: involvement of glucagon-like peptide-1. Obes Res 13:1000–1007CrossRef
go back to reference Casellas F, Borruel N, Torrejón A, Varela E, Antolin M, Guarner F, Malagelada J-R (2007). Oral oligofructose-enriched inulin supplementation in acute colitis is well tolerated and associated with lower faecal calprotectin. Aliment Pharmacol Ther 25:1061–1067CrossRef Casellas F, Borruel N, Torrejón A, Varela E, Antolin M, Guarner F, Malagelada J-R (2007). Oral oligofructose-enriched inulin supplementation in acute colitis is well tolerated and associated with lower faecal calprotectin. Aliment Pharmacol Ther 25:1061–1067CrossRef
go back to reference Cherbut C, Michel C, Lecannu G (2003) The prebiotic characteristics of fructooligosaccharides are necessary for reduction of TNBS-induced colitis in rats. J Nutr 133:21–27 Cherbut C, Michel C, Lecannu G (2003) The prebiotic characteristics of fructooligosaccharides are necessary for reduction of TNBS-induced colitis in rats. J Nutr 133:21–27
go back to reference Daubioul C, Rousseau N, Demeure R, Gallez B, Taper H, Declerck B, Delzenne N (2002) Dietary fructans, but not cellulose, decrease triglyceride accumulation in the liver of obese Zucker fa/fa rats. J Nutr 132:967–973 Daubioul C, Rousseau N, Demeure R, Gallez B, Taper H, Declerck B, Delzenne N (2002) Dietary fructans, but not cellulose, decrease triglyceride accumulation in the liver of obese Zucker fa/fa rats. J Nutr 132:967–973
go back to reference Davidson MH, Maki KC (1999) Effects of dietary inulin on serum lipids. J Nutr 129:1474S–1477S Davidson MH, Maki KC (1999) Effects of dietary inulin on serum lipids. J Nutr 129:1474S–1477S
go back to reference Delzenne N, Aertssens J, Verplaetse H, Roccaro M, Roberfroid M (1995) Effect of fermentable fructo-oligosaccharides on mineral, nitrogen and energy digestive balance in the rat. Life Sci 57:1579–1587CrossRef Delzenne N, Aertssens J, Verplaetse H, Roccaro M, Roberfroid M (1995) Effect of fermentable fructo-oligosaccharides on mineral, nitrogen and energy digestive balance in the rat. Life Sci 57:1579–1587CrossRef
go back to reference Den Hond E, Geypens B, Ghoos Y (2000) Effect of high performance chicory inulin on constipation. Nutr Res 20:731–736CrossRef Den Hond E, Geypens B, Ghoos Y (2000) Effect of high performance chicory inulin on constipation. Nutr Res 20:731–736CrossRef
go back to reference Duncan SH, Holtrop G, Lobley GE, Calder AG, Stewart CS, Flint HJ (2004) Contribution of acetate to butyrate formation by human faecal bacteria. Br J Nutr 91:915–923CrossRef Duncan SH, Holtrop G, Lobley GE, Calder AG, Stewart CS, Flint HJ (2004) Contribution of acetate to butyrate formation by human faecal bacteria. Br J Nutr 91:915–923CrossRef
go back to reference Falony G, Vlachou A, Verbrugge K, De Vuyst L (2006) Cross-feeding between Bifidobacterium longum BB536 and acetate-converting, butyrate-producing colon bacteria during growth on oligofructose. Appl Environ Microbiol 72:7835–7841CrossRef Falony G, Vlachou A, Verbrugge K, De Vuyst L (2006) Cross-feeding between Bifidobacterium longum BB536 and acetate-converting, butyrate-producing colon bacteria during growth on oligofructose. Appl Environ Microbiol 72:7835–7841CrossRef
go back to reference Firmansyah A, Pramita G, Fassler C, Haschke F, Link-Amster H (2001) Improved humoral immune response to measles vaccine in infants receiving infant cereal with fructooligosaccharides. J Pediatr Gastroenterol Nutr 31:A521 Firmansyah A, Pramita G, Fassler C, Haschke F, Link-Amster H (2001) Improved humoral immune response to measles vaccine in infants receiving infant cereal with fructooligosaccharides. J Pediatr Gastroenterol Nutr 31:A521
go back to reference Fisberg M, Maulen I, Vasquez E, Garcia J, Comer GM, Alarcon PA (2000) Effect of oral supplementation with and without synbiotics on catch-up growth in preschool children. J Pediatr Gastroenterol Nutr 31:A521 Fisberg M, Maulen I, Vasquez E, Garcia J, Comer GM, Alarcon PA (2000) Effect of oral supplementation with and without synbiotics on catch-up growth in preschool children. J Pediatr Gastroenterol Nutr 31:A521
go back to reference Franck A (2002) Technological functionality of inulin and oligofructose. Br J Nutr 87:S287–S291CrossRef Franck A (2002) Technological functionality of inulin and oligofructose. Br J Nutr 87:S287–S291CrossRef
go back to reference Fukushima A, Ohta A, Sakai K, Sakuma K (2005) Expression of calbindin-D9k, VDR and Cdx-2 Messenger RNA in the process by which fructo-oligosaccharides increase calcium absorption in rats. J Nutr Sci Vitaminol 51:426–432 Fukushima A, Ohta A, Sakai K, Sakuma K (2005) Expression of calbindin-D9k, VDR and Cdx-2 Messenger RNA in the process by which fructo-oligosaccharides increase calcium absorption in rats. J Nutr Sci Vitaminol 51:426–432
go back to reference Furrie E, Macfarlane S, Kennedy A, Cummings JH, Walsh SV, O’Neil DA, Macfarlane GT (2005) Synbiotic therapy (Bifidobacterium longum/Synergy1) initiates resolution of inflammation in patients with active ulcerative colitis: a randomized controlled pilot trial. Gut 54:242–249CrossRef Furrie E, Macfarlane S, Kennedy A, Cummings JH, Walsh SV, O’Neil DA, Macfarlane GT (2005) Synbiotic therapy (Bifidobacterium longum/Synergy1) initiates resolution of inflammation in patients with active ulcerative colitis: a randomized controlled pilot trial. Gut 54:242–249CrossRef
go back to reference Gibson GR, Beatty ER, Cummings J (1995a) Selective fermentation of bifidobacteria in the human colon by oligofructose and inulin. Gastroenterology 108:975–982CrossRef Gibson GR, Beatty ER, Cummings J (1995a) Selective fermentation of bifidobacteria in the human colon by oligofructose and inulin. Gastroenterology 108:975–982CrossRef
go back to reference Gibson GR, Probert HM, Van Loo J, Rastall RA Roberfroid MB (2004) Dietary modulation of the human colonic microbiota: updating the concept of prebiotics. Nutr Res Rev 17:259–275CrossRef Gibson GR, Probert HM, Van Loo J, Rastall RA Roberfroid MB (2004) Dietary modulation of the human colonic microbiota: updating the concept of prebiotics. Nutr Res Rev 17:259–275CrossRef
go back to reference Gibson GR, Roberfroid MB (1995b) Dietary modulation of the human colonic microbiota - Introducing the concept of prebiotics. J Nutr 125:1401–1412 Gibson GR, Roberfroid MB (1995b) Dietary modulation of the human colonic microbiota - Introducing the concept of prebiotics. J Nutr 125:1401–1412
go back to reference Griffin IJ, Hicks PMD, Heaney RP, Abrams SA (2003) Enriched chicory inulin increases calcium absorption mainly in girls with lower calcium absorption. Nutr Res 23:901–909CrossRef Griffin IJ, Hicks PMD, Heaney RP, Abrams SA (2003) Enriched chicory inulin increases calcium absorption mainly in girls with lower calcium absorption. Nutr Res 23:901–909CrossRef
go back to reference Hoebregs H (1997) Fructans in foods and food products, ion-exchange chromatographic method: collaborative study. J AOAC 5:80–102 Hoebregs H (1997) Fructans in foods and food products, ion-exchange chromatographic method: collaborative study. J AOAC 5:80–102
go back to reference Hoentjen F, Welling GW, Harmsen HJM, Zhang X, Snart J, Tannock GW, Lien K, Churchill TA, Lupicki M, Dieleman LA (2005) Reduction of colitis by prebiotics in HLA-B27 transgenic rats is associated with microflora changes and immunomodulation. Inflamm Bowel Dis 11:977–985CrossRef Hoentjen F, Welling GW, Harmsen HJM, Zhang X, Snart J, Tannock GW, Lien K, Churchill TA, Lupicki M, Dieleman LA (2005) Reduction of colitis by prebiotics in HLA-B27 transgenic rats is associated with microflora changes and immunomodulation. Inflamm Bowel Dis 11:977–985CrossRef
go back to reference Holloway L, Moynihan S, Abrams SA, Kent K, Hsu AR, Friedlander AL (2007) Effects of oligofructose-enriched inulin on intestinal absorption of calcium and magnesium and bone turnover markers in postmenopausal women. Br J Nutr 97:365–372CrossRef Holloway L, Moynihan S, Abrams SA, Kent K, Hsu AR, Friedlander AL (2007) Effects of oligofructose-enriched inulin on intestinal absorption of calcium and magnesium and bone turnover markers in postmenopausal women. Br J Nutr 97:365–372CrossRef
go back to reference Jackson KG, Taylor GR, Clohessy AM, Williams CM (1999) The effect of the daily intake of inulin on fasting lipid, insulin and glucose concentrations in middle-aged men and women. Br J Nutr 82:23–30 Jackson KG, Taylor GR, Clohessy AM, Williams CM (1999) The effect of the daily intake of inulin on fasting lipid, insulin and glucose concentrations in middle-aged men and women. Br J Nutr 82:23–30
go back to reference Kleessen B, Sykura B, Zunft H-J, Blaut M (1997) Effects of inulin and lactose on feval microbiota, microbial activity, and bowel habit in elderly constipated persons. Am J Clin Nutr 65:1397–1402 Kleessen B, Sykura B, Zunft H-J, Blaut M (1997) Effects of inulin and lactose on feval microbiota, microbial activity, and bowel habit in elderly constipated persons. Am J Clin Nutr 65:1397–1402
go back to reference Klinder A, Förster A, Caderni G, Femia AP, Pool-Zobel NL (2004) Fecal water genotoxicity is predictice of tumor-preventive activities by inulin-like oligofructoses, probiotics (Lactobacillus rhamnosus and Bifidobacterium lactis), and their synbiotic combination. Nutr Cancer 49:144–155CrossRef Klinder A, Förster A, Caderni G, Femia AP, Pool-Zobel NL (2004) Fecal water genotoxicity is predictice of tumor-preventive activities by inulin-like oligofructoses, probiotics (Lactobacillus rhamnosus and Bifidobacterium lactis), and their synbiotic combination. Nutr Cancer 49:144–155CrossRef
go back to reference Kok NN, Morgan LM, Williams CM, Roberfroid MB, Thissen JP, Delzenne NM (1998) Insulin, glucagon-like peptide 1, glucose-dependent insulinotropic polypeptide and insulin-like growth factor I as putative mediators of the hypolipidemic effect of oligofructose in rats. J Nutr 128:1099–1103 Kok NN, Morgan LM, Williams CM, Roberfroid MB, Thissen JP, Delzenne NM (1998) Insulin, glucagon-like peptide 1, glucose-dependent insulinotropic polypeptide and insulin-like growth factor I as putative mediators of the hypolipidemic effect of oligofructose in rats. J Nutr 128:1099–1103
go back to reference Langlands SJ, Hopkins MJ, Coleman N, Cummings JH (2004) Prebiotic carbohydrates modify the mucosa associated microflora of the human large bowel. Gut 53:1610–1616CrossRef Langlands SJ, Hopkins MJ, Coleman N, Cummings JH (2004) Prebiotic carbohydrates modify the mucosa associated microflora of the human large bowel. Gut 53:1610–1616CrossRef
go back to reference Lesniewska V, Rowland I, Laerke HN, Grant G, Naughton PJ (2006) Relationship between dietary-induced changes in intestinal commensal microflora and duodenojejunal myoelectric activity monitored by radiotelemetry in the rat in vivo. Exp Physiology 91:229–237CrossRef Lesniewska V, Rowland I, Laerke HN, Grant G, Naughton PJ (2006) Relationship between dietary-induced changes in intestinal commensal microflora and duodenojejunal myoelectric activity monitored by radiotelemetry in the rat in vivo. Exp Physiology 91:229–237CrossRef
go back to reference Lewis S, Burmeister S, Brazier J (2005) Effect of the prebiotic oligofructose on relapse of Clostridium difficile-associated diarrhea: a randomized, controlled study. Clin Gastroenterol Hepatol 3:442–448CrossRef Lewis S, Burmeister S, Brazier J (2005) Effect of the prebiotic oligofructose on relapse of Clostridium difficile-associated diarrhea: a randomized, controlled study. Clin Gastroenterol Hepatol 3:442–448CrossRef
go back to reference Ley et al. (2006) Human gut microbes associated with obesity. Nature 444:1022–1023CrossRef Ley et al. (2006) Human gut microbes associated with obesity. Nature 444:1022–1023CrossRef
go back to reference Lindsay JO, Whelan K, Stagg AJ, Gobin P, Al-Hassi HO, Raiment N, Kamm MA, Knight SC, Forbes A (2006) Clinical, microbiological and immunological effects of fructo-oligosaccharides in patients with Crohn’s disease. Gut 55:348–355CrossRef Lindsay JO, Whelan K, Stagg AJ, Gobin P, Al-Hassi HO, Raiment N, Kamm MA, Knight SC, Forbes A (2006) Clinical, microbiological and immunological effects of fructo-oligosaccharides in patients with Crohn’s disease. Gut 55:348–355CrossRef
go back to reference Mathey J, Puel C, Kati-Coulibaly S, Bennetau-Pelissero C, Lebecque P, Horcajada MN, Coxam V (2004) Fructo-oligosaccharides maximize bone-spearing effects of soy isoflavone-enriched diet in ovariectomized rat. Calcif Tissue Int 75:169–179CrossRef Mathey J, Puel C, Kati-Coulibaly S, Bennetau-Pelissero C, Lebecque P, Horcajada MN, Coxam V (2004) Fructo-oligosaccharides maximize bone-spearing effects of soy isoflavone-enriched diet in ovariectomized rat. Calcif Tissue Int 75:169–179CrossRef
go back to reference Oli MW, Petschow BW, Buddington RK (1998) Evaluation of fructooligosaccharide supplementation of oral electrolyte solutions for treatment of diarrhea: Recovery of the intestinal bacteria. Dig Dis Sci 43:138–147CrossRef Oli MW, Petschow BW, Buddington RK (1998) Evaluation of fructooligosaccharide supplementation of oral electrolyte solutions for treatment of diarrhea: Recovery of the intestinal bacteria. Dig Dis Sci 43:138–147CrossRef
go back to reference Orrhage K, Sjostedt S, Nord CE (2000) Effects of supplements with lactic acid bacteria. J Antimicrob Chemother 46:603–611CrossRef Orrhage K, Sjostedt S, Nord CE (2000) Effects of supplements with lactic acid bacteria. J Antimicrob Chemother 46:603–611CrossRef
go back to reference Osman N, Adawi D, Molin G, Ahrne S, Berggren A, Jeppsson B (2006) Bifidobacterium infantis strain with and without a combination of oligofructose-enriched inulin (OFI) attenuate inflammation in DSS-induced colitis in rats. BMC Gastroenterology 6:31 (online publication)CrossRef Osman N, Adawi D, Molin G, Ahrne S, Berggren A, Jeppsson B (2006) Bifidobacterium infantis strain with and without a combination of oligofructose-enriched inulin (OFI) attenuate inflammation in DSS-induced colitis in rats. BMC Gastroenterology 6:31 (online publication)CrossRef
go back to reference Paineau D, Payen F, Panserieu S, Coulombier G, Sobaszek A, Lartigau I, Brabet M, Galmiche J-P, Tripodi D, Sacher-Huvelin S, Chapalain V, Zourabichvilli O, Respondek F, Wagner A, Bornet FRJ (2008) The effects of regular consumption of short-chain fructo-oligosaccharides on digestive comport of subjects with minor functional bowel disorders. Br J Nutr 13:311–318 Paineau D, Payen F, Panserieu S, Coulombier G, Sobaszek A, Lartigau I, Brabet M, Galmiche J-P, Tripodi D, Sacher-Huvelin S, Chapalain V, Zourabichvilli O, Respondek F, Wagner A, Bornet FRJ (2008) The effects of regular consumption of short-chain fructo-oligosaccharides on digestive comport of subjects with minor functional bowel disorders. Br J Nutr 13:311–318
go back to reference Rafter J, Bennett M, Caderni G, Clune Y, Hughes R, Karlsson PC, Klinder A, O’ Riordan M, O’Sullivan GC, Pool-Zobel B, Rechkemmer G, Roller M, Rowland I, Salvadori M, Thijs H, Van Loo J, Watzl B, Collins JK (2007) Dietary synbiotics reduce cancer risk factors in polypectomized and colon cancer patients. Am J Clin Nutr 85:488–496 Rafter J, Bennett M, Caderni G, Clune Y, Hughes R, Karlsson PC, Klinder A, O’ Riordan M, O’Sullivan GC, Pool-Zobel B, Rechkemmer G, Roller M, Rowland I, Salvadori M, Thijs H, Van Loo J, Watzl B, Collins JK (2007) Dietary synbiotics reduce cancer risk factors in polypectomized and colon cancer patients. Am J Clin Nutr 85:488–496
go back to reference Rao A (2001) The prebiotic properties of oligofructose at low intake levels. Nutr Res 21:843–848CrossRef Rao A (2001) The prebiotic properties of oligofructose at low intake levels. Nutr Res 21:843–848CrossRef
go back to reference Raschka L, Daniel H (2005) Mechanisms underlying the effects of inulin-type fructans on calcium absorption in the large intestine of rats. Bone 37:728–735CrossRef Raschka L, Daniel H (2005) Mechanisms underlying the effects of inulin-type fructans on calcium absorption in the large intestine of rats. Bone 37:728–735CrossRef
go back to reference Rault-Nania MH, Gueux E, Demougeot C, Demigne C, Rock E, Mazur A (2006) Inulin attenuates atherosclerosis in apolipoprotein E-deficient mice. Br J Nutr 96:840–844CrossRef Rault-Nania MH, Gueux E, Demougeot C, Demigne C, Rock E, Mazur A (2006) Inulin attenuates atherosclerosis in apolipoprotein E-deficient mice. Br J Nutr 96:840–844CrossRef
go back to reference Roberfroid MB, Cumps J, Devogelaer JP (2002) Dietary chicory inulin increases whole-body bone mineral density in growing male rats. J Nutr 132:3599–3602 Roberfroid MB, Cumps J, Devogelaer JP (2002) Dietary chicory inulin increases whole-body bone mineral density in growing male rats. J Nutr 132:3599–3602
go back to reference Roberfroid M, Gibson G, Delzenne N (1993) Biochemistry of oligofructose, a non-digestible fructooligosaccharide: an approach to estimate its caloric value. Nutr Rev 51:137CrossRef Roberfroid M, Gibson G, Delzenne N (1993) Biochemistry of oligofructose, a non-digestible fructooligosaccharide: an approach to estimate its caloric value. Nutr Rev 51:137CrossRef
go back to reference Roller M, Femia AP, Caderni G, Rechkemmer G, Watzl B (2004) Intestinal immunity of rats with colon cancer is modulated by oligofructose-enriched inulin combined with Lactobacillus rhamnosus and Bifidobacterium lactis. Br J Nutr 92:931–938CrossRef Roller M, Femia AP, Caderni G, Rechkemmer G, Watzl B (2004) Intestinal immunity of rats with colon cancer is modulated by oligofructose-enriched inulin combined with Lactobacillus rhamnosus and Bifidobacterium lactis. Br J Nutr 92:931–938CrossRef
go back to reference Saavedra J, Tschernia A (2002) Human studies with probiotics and prebiotics: clinical implications. Br J Nutr 87:S241–S246CrossRef Saavedra J, Tschernia A (2002) Human studies with probiotics and prebiotics: clinical implications. Br J Nutr 87:S241–S246CrossRef
go back to reference Sauer J, Richter KK, Pool-Zobel BL (2007) Products formed during fermentation of the prebiotic inulin with human gut flora enhances expression of biotransformation genes in human primary colon cells. Br J Nutr 97:928–937CrossRef Sauer J, Richter KK, Pool-Zobel BL (2007) Products formed during fermentation of the prebiotic inulin with human gut flora enhances expression of biotransformation genes in human primary colon cells. Br J Nutr 97:928–937CrossRef
go back to reference Scholtens PAM, Alles MS, Willemsen LEM, van der Braak C, Bindels JG, Boehm G, Govers MJAP (2006) Dietary fructo-oligosaccharides in healthy adults do not negatively affect faecal cytotoxicity: a randomised, double-blind, placebo-controlled crossover trial. Br J Nutr 95:1143–1149CrossRef Scholtens PAM, Alles MS, Willemsen LEM, van der Braak C, Bindels JG, Boehm G, Govers MJAP (2006) Dietary fructo-oligosaccharides in healthy adults do not negatively affect faecal cytotoxicity: a randomised, double-blind, placebo-controlled crossover trial. Br J Nutr 95:1143–1149CrossRef
go back to reference Scholz-Ahrens KE, Acil Y, Schrezenmeir J (2002) Effect of oligofructose or dietary calcium on repeated calcium and phosphorus balances, bone mineralization and trabecular structure in ovariectomized rats. Br J Nutr 88:365–377CrossRef Scholz-Ahrens KE, Acil Y, Schrezenmeir J (2002) Effect of oligofructose or dietary calcium on repeated calcium and phosphorus balances, bone mineralization and trabecular structure in ovariectomized rats. Br J Nutr 88:365–377CrossRef
go back to reference Steegmans M, Iliaens S, Hoebregs H (2004) Enzymatic, spectrophotometric determination of glucose, fructose, sucrose and inulin/oligofructose in foods. J AOAC Int 87:1200–1207 Steegmans M, Iliaens S, Hoebregs H (2004) Enzymatic, spectrophotometric determination of glucose, fructose, sucrose and inulin/oligofructose in foods. J AOAC Int 87:1200–1207
go back to reference Ten Bruggencate SJ, Bovee-Oudenhoven IM, Lettink-Wissink ML, Katan MB, Van der Meer R (2004) Dietary fructo-oligosaccharides and inulin decrease resistance of rats to Salmonella: protective role of calcium. Gut 53:530–535CrossRef Ten Bruggencate SJ, Bovee-Oudenhoven IM, Lettink-Wissink ML, Katan MB, Van der Meer R (2004) Dietary fructo-oligosaccharides and inulin decrease resistance of rats to Salmonella: protective role of calcium. Gut 53:530–535CrossRef
go back to reference Tuohy KM (2001) A human volunteer study on the prebiotic effects of HP-inulin-faecal bacteria enumerated using fluorescent in situ hybridisation (FISH). Anaerobe 7:113–118CrossRef Tuohy KM (2001) A human volunteer study on the prebiotic effects of HP-inulin-faecal bacteria enumerated using fluorescent in situ hybridisation (FISH). Anaerobe 7:113–118CrossRef
go back to reference Van Loo J, Coussement P, De Leenheer L, Hoebregs H, Smits G (1995) On the presence of inulin and oligofructose as natural ingredients in the Western diet. Crit Rev Food Sci Nutr 35:525–552CrossRef Van Loo J, Coussement P, De Leenheer L, Hoebregs H, Smits G (1995) On the presence of inulin and oligofructose as natural ingredients in the Western diet. Crit Rev Food Sci Nutr 35:525–552CrossRef
go back to reference Verghese M, Walker LT, Shackelford L, Chawan CB (2005) Inhibitory effects of nondigestible carbohydrates of different chain lengths on azoxymethane-induced aberrant crypt foci in Fisher 344 rats. Nutr Res 25:859–868CrossRef Verghese M, Walker LT, Shackelford L, Chawan CB (2005) Inhibitory effects of nondigestible carbohydrates of different chain lengths on azoxymethane-induced aberrant crypt foci in Fisher 344 rats. Nutr Res 25:859–868CrossRef
go back to reference Videla S, Vilaseca J, Antolin M, Garcia-Lafuente A, Guarner F, Crespo E, Casalots J, Salas A, Malagelada JR (2001) Dietary inulin improves distal colitis induced by dextran sodium sulfate in the rat. Am J Gastroenterol 96:1486–1493CrossRef Videla S, Vilaseca J, Antolin M, Garcia-Lafuente A, Guarner F, Crespo E, Casalots J, Salas A, Malagelada JR (2001) Dietary inulin improves distal colitis induced by dextran sodium sulfate in the rat. Am J Gastroenterol 96:1486–1493CrossRef
go back to reference Waligora-Dupriet A-J, Campeotto F, Nicolis I, Bonet A, Soulaines P, Dupont C, Butel M-J (2007) Effect of oligofructose supplementation on gut microflora and well-being in young children attending a day care centre. Int J Food Microbiol 113:108–113CrossRef Waligora-Dupriet A-J, Campeotto F, Nicolis I, Bonet A, Soulaines P, Dupont C, Butel M-J (2007) Effect of oligofructose supplementation on gut microflora and well-being in young children attending a day care centre. Int J Food Microbiol 113:108–113CrossRef
go back to reference Welters CF, Heineman E, Thunnissen FB, van den Bogaard AE, Soeters PB, Baeten CG (2002) Effect of dietary inulin supplementation on inflammation of pouch mucosa in patients with an ileal pouch-anal anastomosis. Dis Colon Rectum 45:621–627CrossRef Welters CF, Heineman E, Thunnissen FB, van den Bogaard AE, Soeters PB, Baeten CG (2002) Effect of dietary inulin supplementation on inflammation of pouch mucosa in patients with an ileal pouch-anal anastomosis. Dis Colon Rectum 45:621–627CrossRef
go back to reference Whelan K, Efthymiou L, Judd PA, Preedy VR, Taylor MA (2006) Appetite during consumption of enteral formula as a sole source of nutrition: the effect of supplementing pea-fibre and fructo-oligosaccharides. Br J Nutr 96:350–356CrossRef Whelan K, Efthymiou L, Judd PA, Preedy VR, Taylor MA (2006) Appetite during consumption of enteral formula as a sole source of nutrition: the effect of supplementing pea-fibre and fructo-oligosaccharides. Br J Nutr 96:350–356CrossRef
go back to reference Yasuda K, Roneker K, Miller D, Welch R, Lei XG (2006) Supplemental dietary inulin affects the bioavailability of iron in corn and soybean meal to young pigs. J Nutr 136:3033–3038 Yasuda K, Roneker K, Miller D, Welch R, Lei XG (2006) Supplemental dietary inulin affects the bioavailability of iron in corn and soybean meal to young pigs. J Nutr 136:3033–3038
go back to reference Zafar TA, Weaver CM, Zhao Y, Martin BR, Wastney ME (2004) Nondigestible oligosaccharides increase calcium absorption and suppress bone resorption in ovariectomized rats. J Nutr 134:399–402 Zafar TA, Weaver CM, Zhao Y, Martin BR, Wastney ME (2004) Nondigestible oligosaccharides increase calcium absorption and suppress bone resorption in ovariectomized rats. J Nutr 134:399–402
go back to reference Zunft H-JF, Hanisch C, Mueller S, Koebnick C, Blaut M, Doré J (2004) Synbiotic containing Bifidobacterium animalis and inulin increases stool frequency in elderly healthy people. Asia Pac J Clin Nutr 13:112 Zunft H-JF, Hanisch C, Mueller S, Koebnick C, Blaut M, Doré J (2004) Synbiotic containing Bifidobacterium animalis and inulin increases stool frequency in elderly healthy people. Asia Pac J Clin Nutr 13:112
Metadata
Title
Fructan Prebiotics Derived from Inulin
Author
Douwina Bosscher
Copyright Year
2009
Publisher
Springer New York
DOI
https://doi.org/10.1007/978-0-387-79058-9_6

Premium Partners