2005 | OriginalPaper | Chapter
Genome Rearrangement in Mitochondria and Its Computational Biology
Authors : István Miklós, Jotun Hein
Published in: Comparative Genomics
Publisher: Springer Berlin Heidelberg
Activate our intelligent search to find suitable subject content or patents.
Select sections of text to find matching patents with Artificial Intelligence. powered by
Select sections of text to find additional relevant content using AI-assisted search. powered by
In the first part of this paper, we investigate gene orders of closely related mitochondrial genomes for studying the properties of mutations rearranging genes in mitochondria. Our conclusions are that the evolution of mitochondrial genomes is more complicated than it is considered in recent methods, and stochastic modelling is necessary for its deeper understanding and more accurate inferring. The second part is a review on the Markov chain Monte Carlo approaches for the stochastic modelling of genome rearrangement, which seem to be the only computationally tractable way to this problem. We introduce the concept of partial importance sampling, which yields a class of Markov chains being efficient both in terms of mixing and computational time. We also give a list of open algorithmic problems whose solution might help improve the efficiency of partial importance samplers.