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GPR119 Promising Ligands: A Computational Analysis of New Strategies Against Type 2 Diabetes Mellitus

  • 2025
  • OriginalPaper
  • Chapter
Published in:
Authors
Luiz Felipe M. A. Benicio
Érica C. M. Nascimento
João Batista Lopes Martins
Published in
Computational Intelligence in Drug Development
Publisher
Springer Nature Switzerland

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Abstract

This chapter delves into the promising role of GPR119 ligands in the treatment of type 2 diabetes mellitus, focusing on computational analysis to identify new therapeutic strategies. The text explores the interaction between GPR119 and various ligands, including nortropanol derivatives, pyrazolopyrimidines, and spirocyclic cyclohexanes, highlighting their potential to induce insulin secretion and improve glycemic control. The study employs docking studies and ADMET analysis to evaluate the pharmacokinetic and toxicological profiles of these ligands, providing insights into their efficacy and safety. The results indicate that spirocyclic cyclohexane derivatives show the greatest potential for interaction with GPR119, with EC50 values in the nanomolar and micromolar range. The heatmap analysis further clusters these ligands into distinct groups, revealing similarities in their pharmacokinetic properties. Overall, this chapter offers a comprehensive overview of the potential of GPR119 ligands as a novel approach to managing type 2 diabetes mellitus, making it a compelling read for professionals in the field.
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Title
GPR119 Promising Ligands: A Computational Analysis of New Strategies Against Type 2 Diabetes Mellitus
Authors
Luiz Felipe M. A. Benicio
Érica C. M. Nascimento
João Batista Lopes Martins
Copyright Year
2025
Book
Computational Intelligence in Drug Development

Print ISBN: 978-3-032-07365-5

Electronic ISBN: 978-3-032-07366-2

Copyright Year: 2025

DOI
https://doi.org/10.1007/978-3-032-07366-2_3
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