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Journal of Materials Science

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19-07-2016 | Original Paper

High refractive index TiO₂-PHEMA hydrogel for ophthalmological applications

Authors: Hendrik M. Reinhardt, Dominik Recktenwald, Hee-Cheol Kim, Norbert A. Hampp

Published in: Journal of Materials Science | Issue 22/2016

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Abstract

A facile route for the synthesis of PHEMA hydrogel incorporating anatase nanoparticles is presented. The hydrogel features a refractive index of 1.527 and high transparency throughout the visual spectral range. Saturn rings have been machined in order to investigate the workability of the material and its potential applicability as intraocular lens implant. The resulting lenses feature high surface quality, foldability, and shape memory which makes them suitable for implantation via extracapsular cataract extraction.

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Thylefors B, Negrel AD, Pararajasegaram R, Dadzie KY (1995) Global data on blindness. Bull World Health Organ 73:115–121

Resnikoff S, Pascolini D, Etya’ale D, Kocur I, Pararajasegaram R, Pokharel GP, Mariotti SP (2004) Global data on visual impairment in the year 2002. Bull World Health Organ 82:844–851

Brian G, Taylor H (2001) Cataract blindness—challenges for the 21st century. Bull World Health Organ 79:249–256

Vos JJ, Van Norren D (2004) Thermal cataract, from furnaces to lasers. Clin Exp Optom 87:372–376CrossRef

Kottler UB, Dick HB, Augustin AJ (2003) Is a cataract avoidable? current status with special emphasis on the pathophysiology of oxidative lens damage, nutritional factors, and the ARED study. Ophthalmologe 100:190–196CrossRef

Kästle M, Grune T (2011) Protein oxidative modification in the aging organism and the role of the ubiquitin proteasomal system. Curr Pharm Des 17:4007–4022CrossRef

Harding JJ (1991) Post-translational modification of lens proteins in cataract. Lens Eye Toxic Res 8:245–250

Liu JP, Zhang JS (2011) Advances in studies on effects of osmotic pressure in occurrence of cataract. Int J Ophthalmol 11:1169–1171

De Iongh RU, Wederell E, Lovicu FJ, McAvoy JW (2005) Transforming growth factor-β-induced epithelial-mesenchymal transition in the lens: a model for cataract formation. Cells Tissues Organs 179:43–55CrossRef

10.

Goldacre MJ, Wotton CJ, Keenan TDL (2012) Risk of selected eye diseases in people admitted to hospital for hypertension or diabetes mellitus: record linkage studies. Br J Ophthalmol 96:872–876CrossRef

11.

Tezel G, Kolker AE, Kass MA, Wax MB (1997) Comparative results of combined procedures for glaucoma and cataract: I. extracapsular cataract extraction versus phacoemulsification and foldable versus rigid intraocular lenses. Ophthalmic Surg Lasers 28:539–550

12.

Grehn F (2008) Augenheilkunde. Springer Medizin Verlag, Heidelberg

13.

Mateo NB, Ratner BD (1989) Relating the surface properties of intraocular lens materials to endothelial cell adhesion damage. Invest Ophthalmol Vis Sci 30:853

14.

Hollick EJ, Spalton DJ, Lirsel PC (1999) The effect of polymethyl-methacrylate, silicone and polyacrylic intraocular lenses on posterior capsular opacification 3 years after cataract surgery. Ophthalmol 106:49–59CrossRef

15.

Kecova H, Necas A (2004) Phacoemulsification and intraocular lens implantation: recent trends in cataract surgery. Acta Vet Brno 73:85–92CrossRef

16.

Leaming DV (2004) Practice styles and preferences of ASCRS members—survey. J Cataract Refract Surg 30:892–900CrossRef

17.

Kato K et al (2001) Glistening formation in an AcrySof lens initiated by spinodal decomposition of the polymer network by temperature change. J Cataract Refract Surg 27:1493–1498CrossRef

18.

Seward HC (1997) Folding intraocular lenses: materials and methods. Br J Ophthalmol 81:340–341CrossRef

19.

Espandar L, Sikder S, Majid M (2011) Softec HD hydrophilic acrylic intraocular lens: biocompatibility and precision. Clin Ophthalmol 5:65–70

20.

Sung AY, Kim TH (2012) Ophthalmic application of poly(HEMA)s containing nanoparticles and dimethylacrylamide. J Nanosci Nanotechnol 12:5210–5215CrossRef

21.

Zhang et al (2012) High refractive index inorganic—organic interpenetrating polymer network (IPN) hydrogel nanocomposite toward artificial cornea implants. ACS Macro Lett 1:876–881CrossRef

22.

Caseri WR (2006) Polymer nanocomposites: microstructure control, properties and processing. Mater Sci Technol 22:807CrossRef

23.

Tsuzuki T (2008) Abnormal transmittance of refractive-index-modified ZnO/Organic hybrid films. Macromol Mater Eng 293:109–113CrossRef

24.

Lü C, Yang B (2009) High refractive index organic–inorganic nanocomposites: design, synthesis and application. J Mater Chem 19:2884–2901CrossRef

25.

Jintoku H, Ihara H (2014) The simplest method for fabrication of high refractive index polymer-metal oxide hybrids based on a soap-free process. Chem Comm 50:10611–10614CrossRef

26.

Asai T, Sakamoto W, Yogo T (2013) In situ synthesis of transparent TiO2 nanoparticle/polymer hybrid. J Mater Sci 48:7503–7509CrossRef

27.

Prashantha K, Rashmi BJ, Venkatesha TV, Lee JH (2006) Spectral characterization of apatite formation on poly(2-hydroxyethylmethacrylate)–TiO2 nanocomposite film prepared by sol–gel process. Spectrochim Acta A Mol Biomol Spectrosc 65:340–344CrossRef

28.

Guan C, Lü CL, Liu YF, Yang B (2006) Preparation and characterization of high refractive index thin films of TiO2/Epoxy resin nanocomposites. J Appl Polym Sci 102:1631–1636CrossRef

29.

Moret MP, Zallen R, Vijay DP, Desu SB (2000) Brookite-rich titania films made by pulsed laser deposition. Thin Solid Films 366:8–10CrossRef

30.

Sammelselg V, Rosental A, Tarre A, Niinisto L, Heiskanen K, Ilmonen K, Johansson LS, Uustare T (1998) TiO2 thin films by atomic layer deposition: a case of uneven growth at low temperature. Appl Surf Sci 134:78–86CrossRef

31.

Ranade M et al (2002) Energetics of nanocrystalline TiO2. Proc Natl Acad Sci USA 99:6476–6481CrossRef

32.

Soler-Illia G, Louis A, Sanchez C (2002) Synthesis and characterization of mesostructured titania-based materials through evaporation-induced self-assembly. Chem Mat 14:750–759CrossRef

33.

Yu JC, Zhang LZ, Zheng Z, Zhao JC (2003) Synthesis and characterization of phosphated mesoporous titanium dioxide with high photocatalytic activity. Chem Mat 15:2280–2286CrossRef

34.

Thakur VK, Tan EJ, Lin MF, Lee PS (2011) Poly(vinylidene fluoride)-graft-poly(2-hydroxyethyl methacrylate): a novel material for high energy density capacitors. J Mater Chem 21:3751–3759CrossRef

35.

Asai T, Sakamoto W, Yogo T (2013) In situ synthesis of transparent TiO2 nanoparticle/polymer hybrid. J Mater Sci 48:7503–7509CrossRef

36.

Costantini A, Luciani G, Annunziata G, Silvestri B, Branda F (2006) Swelling properties and bioactivity of silica gel/pHEMA nanocomposites. J Mater Sci Mater Med 17:319–325CrossRef

37.

El-Rady AAA, El-Sadek MSA, Breky MMES, Assaf FH (2013) Characterization and photocatalytic efficiency of palladium doped-TiO2 nanoparticles. Adv Nanopart 2:372–377CrossRef

Title: High refractive index TiO2-PHEMA hydrogel for ophthalmological applications
Authors: Hendrik M. Reinhardt
Dominik Recktenwald
Hee-Cheol Kim
Norbert A. Hampp
Publication date: 19-07-2016
Publisher: Springer US
Published in: Journal of Materials Science / Issue 22/2016
Print ISSN: 0022-2461
Electronic ISSN: 1573-4803
DOI: https://doi.org/10.1007/s10853-016-0224-x

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