Highly and fully automated vehicles allow a multitude of new interior ideas and interactions between humans and vehicles. In this paper, relevant aspects that are affected by the introduction of such high levels of automated driving are identified and the implications on different human-machine-interfaces against the background of four different vehicle concepts will be discussed. The paper is structured according to a disintegrated version of the driver-vehicle-control- loop, which in its original version can be used to analyse driver-vehicle interaction for manual and assisted driving. Based upon that, the paper presents potential activities as requested by users, as well as required functions for exploiting the full potential of AVs. As discussed in the paper, one of the major impact on interior and interaction design could result from alternative seating concepts. These would allow an improved user experience on the one hand, but would incorporate various challenges on the other hand.