Top

Published in:

2023 | OriginalPaper | Chapter

2. Identification of Small-Molecule Inhibitors of Oncogenic Lin28–Let-7 Interaction

Author : Dr. Wan Gi Byun

Published in: Discovery of Small-Molecule Modulators of Protein–RNA Interactions for Treating Cancer and COVID-19

Publisher: Springer Nature Singapore

Activate our intelligent search to find suitable subject content or patents.

search-config

AI-assisted search

Off

Abstract

MicroRNAs (miRNAs) are small noncoding RNAs that function as guide molecules in RNA silencing to regulate gene expression. They work by base pairing with the 3′ untranslated region (UTR) of their target messenger RNAs (mRNAs).

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

über 102.000 Bücher
über 537 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Finance + Banking
Management + Führung
Marketing + Vertrieb
Maschinenbau + Werkstoffe
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

inform now

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 390 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Maschinenbau + Werkstoffe

Jetzt Wissensvorsprung sichern!

inform now

previous chapter Introduction

next chapter Discovery of Small-Molecule Modulators of Protein–RNA Interactions by Fluorescence Intensity-Based Binding Assay

Ha M, Kim VN (2014) Nat Rev Mol Cell Biol 15:509–524CrossRef

Huntzinger E, Izaurralde E (2011) Nat Rev Genet 12:99–110CrossRef

van Kouwenhove M, Kedde M, Agami R (2011) Nat Rev Cancer 11:644–656CrossRef

Dong HF, Lei JP, Ding L, Wen YQ, Ju HX, Zhang XJ (2013) Chem Rev 113:6207–6233CrossRef

Garzon R, Marcucci G, Croce CM (2010) Nat Rev Drug Discovery 9:775–789CrossRef

Li ZH, Rana TM (2014) Nat Rev Drug Discovery 13:622–638CrossRef

Li QJ, Chau J, Ebert PJR, Sylvester G, Min H, Liu G, Braich R, Manoharan M, Soutschek J, Skare P, Klein LO, Davis MM, Chen CZ (2007) Cell 129:147–161CrossRef

Thomas JR, Hergenrother PJ (2008) Chem Rev 108:1171–1224CrossRef

Heo I, Joo C, Kim YK, Ha M, Yoon MJ, Cho J, Yeom KH, Han J, Kim VN (2009) Cell 138:696–708CrossRef

10.

Trang P, Medina PP, Wiggins JF, Ruffino L, Kelnar K, Omotola M, Homer R, Brown D, Bader AG, Weidhaas JB, Slack FJ (2010) Oncogene 29:1580–1587CrossRef

11.

Chen PS, Su JL, Cha ST, Tarn WY, Wang MY, Hsu HC, Lin MT, Chu CY, Hua KT, Chen CN, Kuo TC, Chang KJ, Hsiao M, Chang YW, Chen JS, Yang PC, Kuo ML (2011) J Clin Invest 121:3442–3455CrossRef

12.

Boyerinas B, Park SM, Hau A, Murmann AE, Peter ME (2010) Endocr.-Relat. Cancer 17:F19–F36

13.

Xia Y, Zhu Y, Zhou XY, Chen YJ (2014) Tumor Biol 35:5143–5148CrossRef

14.

Buechner J, Tomte E, Haug BH, Henriksen JR, Lokke C, Flaegstad T, Einvik C (2011) Br J Cancer 105:296–303CrossRef

15.

Piskounova E, Polytarchou C, Thornton JE, LaPierre RJ, Pothoulakis C, Hagan JP, Iliopoulos D, Gregory RI (2011) Cell 147:1066–1079CrossRef

16.

Viswanathan SR, Daley GQ, Gregory RI (2008) Science 320:97–100ADSCrossRef

17.

Thornton JE, Gregory RI (2012) Trends Cell Biol 22:474–482CrossRef

18.

Chang HM, Triboulet R, Thornton JE, Gregory RI (2013) Nature 497:244–248ADSCrossRef

19.

Ng SC, Daley GQ (2013) Cell Stem Cell 12:395–406CrossRef

20.

Yu F, Yao H, Zhu P, Zhang X, Pan Q, Gong C, Huang Y, Hu X, Su F, Lieberman J, Song E (2007) Cell 131:1109–1123CrossRef

21.

Viswanathan SR, Powers JT, Einhorn W, Hoshida Y, Ng TL, Toffanin S, O’Sullivan M, Lu J, Phillips LA, Lockhart VL, Shah SP, Tanwar PS, Mermel CH, Beroukhim R, Azam M, Teixeira J, Meyerson M, Hughes TP, Llovet JM, Radich J, Mullighan CG, Golub TR, Sorensen PH, Daley GQ (2009) Nat Genet 41:843–848CrossRef

22.

Zhang WC, Shyh-Chang N, Yang H, Rai A, Umashankar S, Ma SM, Soh BS, Sun LL, Tai BC, Nga ME, Bhakoo KK, Jayapal SR, Nichane M, Yu Q, Ahmed DA, Tan C, Sing WP, Tam J, Thirugananam A, Noghabi MS, Pang YH, Ang HS, Mitchell W, Robson P, Kaldis P, Soo RA, Swarup S, Hsuen E, Lim B (2012) Cell 148:259–272CrossRef

23.

Hayashi S, Tanaka J, Okada S, Isobe T, Yamamoto G, Yasuhara R, Irie T, Akiyama C, Kohno Y, Tachikawa T, Mishima K (2013) Exp Cell Res 319:1220–1228CrossRef

24.

Zhou JB, Ng SB, Chng WJ (2013) Int J Biochem Cell Biol 45:973–978CrossRef

25.

Roos M, Rebhan MAE, Lucic M, Pavlicek D, Pradere U, Towbin H, Civenni G, Catapano CV, Hall J (2015) Nucleic Acids Res 43:e9CrossRef

26.

Roos M (2015) Ph.D. Thesis, ETH Zürich, Nr. 22468, Switzerland

27.

Roos M, Pradère U, Ngondo RP, Behera A, Allegrini S, Civenni G, Zagalak JA, Marchand JR, Menzi M, Towbin H, Scheuermann J, Neri D, Caflisch A, Catapano CV, Ciaudo C, Hall J (2016) ACS Chem Biol 11:2773–2781

28.

Velagapudi SP, Gallo SM, Disney MD (2014) Nat Chem Biol 10:291–297CrossRef

29.

Berney C, Danuser G (2003) Biophys J 84:3992–4010CrossRef

30.

Milroy LG, Grossmann TN, Hennig S, Brunsveld L, Ottmann C (2014) Chem Rev 114:4695–4748CrossRef

31.

Piston DW, Kremers GJ (2007) Trends Biochem Sci 32:407–414CrossRef

32.

Sahoo H (2012) RSC Adv 2:7017–7029ADSCrossRef

33.

Nam Y, Chen C, Gregory RI, Chou JJ, Sliz P (2011) Cell 147:1080–1091CrossRef

34.

Loughlin FE, Gebert LF, Towbin H, Brunschweiger A, Hall J, Allain FH (2012) Nat Struct Mol Biol 19:84–89CrossRef

35.

Triboulet R, Pirouz M, Gregory RI (2015) Cell Rep 13:260–266CrossRef

36.

Liu CC, Schultz PG (2010) Annu Rev Biochem 79:413–444CrossRef

37.

Young TS, Ahmad I, Yin JA, Schultz PG (2010) J Mol Biol 395:361–374CrossRef

38.

Johnson DBF, Xu JF, Shen ZX, Takimoto JK, Schultz MD, Schmitz RJ, Xiang Z, Ecker JR, Briggs SP, Wang L (2011) Nat Chem Biol 7:779–786CrossRef

39.

O’Donoghue P, Ling J, Wang YS, Soll D (2013) Nat Chem Biol 9:594–598CrossRef

40.

Cridge AG, Major LL, Mahagaonkar AA, Poole ES, Isaksson LA, Tate WP (2006) Nucleic Acids Res 34:1959–1973CrossRef

41.

Dommerholt J, Schmidt S, Temming R, Hendriks LJA, Rutjes FPJT, van Hest JCM, Lefeber DJ, Friedl P, van Delft FL (2010) Angew Chem Int Ed 49:9422–9425

42.

Zhang JH, Chung TDY, Oldenburg KR (1999) J Biomol Screening 4:67–73CrossRef

43.

Kim J, Kim H, Park SB (2014) J Am Chem Soc 136:14629–14638CrossRef

44.

Pagano JM, Clingman CC, Ryder SP (2011) RNA 17:14–20CrossRef

45.

Park SO, Kim J, Koh M, Park SB (2009) J Comb Chem 11:315–326CrossRef

46.

Nowak JS, Choudhury NR, Alves FD, Rappsilber J, Michlewski G (2014) Nat Commun 5:3687ADSCrossRef

47.

Warrander F, Faas L, Kovalevskiy O, Peters D, Coles M, Antson AA, Genever P, Isaacs HV (2016) Dev Dyn 245:34–46CrossRef

48.

Melton C, Judson RL, Blelloch R (2010) Nature 463:621–626ADSCrossRef

49.

Guan LR, Disney MD (2012) ACS Chem Biol 7:73–86CrossRef

50.

Clingman CC, Deveau LM, Hay SA, Genga RM, Shandilya SMD, Massi F, Ryder SP (2014) Elife 3:e02848CrossRef

51.

Park J-E, Heo I, Tian Y, Simanshu DK, Chang H, Jee D, Patel DJ, Kim VN (2011) Nature 475:201–205CrossRef

52.

Melton C, Judson RL, Blelloch R (2010) Nature 464:621–626ADSCrossRef

53.

Gerstberger S, Hafner M, Tuschl T (2014) Nat Rev Genet 15:829–845CrossRef

54.

Jankowsky E, Harris ME (2015) Nat Rev Mol Cell Biol 16:533–544CrossRef

55.

Pereira B, Billaud M, Almeida R (2017) Trends Cancer 3:506–528CrossRef

56.

Li Y, Kowdley KV (2012) Proteomics Bioinf 10:246–253

57.

Velagapudi SP, Cameron MD, Haga CL, Rosenberg LH, Lafitte M, Duckett DR, Phinney DG, Disney MD (2016) Proc Natl Acad Sci USA 113:5898–5903ADSCrossRef

58.

Disney MD, Angelbello AJ (2016) Acc Chem Res 49:2698–2704CrossRef

59.

Velagapudi SP, Luo Y, Tran T, Haniff HS, Nakai Y, Fallahi M, Martinez GJ, Childs-Disney JL, Disney MD (2017) ACS Cent Sci 3:205–216CrossRef

60.

Balzeau J, Menezes MR, Cao SY, Hagan JP (2017) Front Genet 8:1–16CrossRef

61.

Faehnle CR, Walleshauser J, Joshua-Tor L (2017) Nat Struct Mol Biol 24:658–665CrossRef

62.

Wang LF, Nam Y, Lee AK, Yu CX, Roth K, Chen C, Ransey EM, Sliz P (2017) Cell Rep 18:2664–2675CrossRef

63.

Jin B, Wang W, Meng XX, Du G, Li J, Zhang SZ, Zhou BH, Fu ZH (2016) BMC Cancer 16:863CrossRef

64.

Sun X, Liu J, Xu C, Tang SC, Ren H (2016) J Cell Mol Med 20:1779–1788CrossRef

65.

Peng F, Li TT, Wang KL, Xiao GQ, Wang JH, Zhao HD, Kang ZJ, Fan WJ, Zhu LL, Li M, Cui B, Zheng FM, Wang HJ, Lam EW, Wang B, Xu J, Liu Q (2017) Cell Death Dis 8:e2569

66.

Lim D, Byun WG, Koo JY, Park H, Park SB (2016) J Am Chem Soc 138:13630–13638CrossRef

67.

Roos M, Pradere U, Ngondo RP, Behera A, Allegrini S, Civenni G, Zagalak JA, Marchand JR, Menzi M, Towbin H, Scheuermann J, Neri D, Caflisch A, Catapano CV, Ciaudo C, Hall J (2016) ACS Chem Biol 11:2773–2781CrossRef

68.

Michlewski G, Caceres JF (2010) Nat Struct Mol Biol 17:1011–1018CrossRef

69.

Wang L, Rowe RG, Jaimes A, Yu C, Nam Y, Pearson DS, Zhang J, Xie X, Marion W, Heffron GJ, Daley GQ, Sliz P (2018) Cell Rep 23:3091–3101CrossRef

70.

Peng S, Maihle NJ, Huang Y (2010) Oncogene 29:2153–2159CrossRef

71.

Zhong X, Li N, Liang S, Huang Q, Coukos G, Zhang L (2010) J Biol Chem 285:41961–41971CrossRef

72.

Liu Y, Li H, Feng J, Cui X, Huang W, Li Y, Su F, Liu Q, Zhu J, Lv X, Chen J, Huang D, Yu F (2013) PLoS One 8:e83083

73.

Ran FA, Hsu PD, Wright J, Agarwala V, Scott DA, Zhang F (2013) Nat Protoc 8:2281–2308CrossRef

74.

Mayr C, Hemann MT, Bartel DP (2007) Science 315:1576–1579ADSCrossRef

75.

Busch B, Bley N, Muller S, Glass M, Misiak D, Lederer M, Vetter M, Strauss HG, Thomssen C, Huttelmaier S (2016) Nucleic Acids Res 44:3845–3864CrossRef

76.

Moon BS, Jeong WJ, Park J, Kim TI, Min DS, Choi KY (2014) J Natl Cancer Inst 106:djt373

77.

Madison BB, Jeganathan AN, Mizuno R, Winslow MM, Castells A, Cuatrecasas M, Rustgi AK (2015) PLoS Genet 11:e1005408

78.

Degrauwe N, Suva ML, Janiszewska M, Riggi N, Stamenkovic I (2016) Genes Dev 30:2459–2474CrossRef

79.

Sun J, Sun B, Zhu D, Zhao X, Zhang Y, Dong X, Che N, Li J, Liu F, Zhao N, Zhang D, Liu T, Lin X (2017) Sci Rep 7:260–274ADSCrossRef

80.

Najumudeen AK, Jaiswal A, Lectez B, Oetken-Lindholm C, Guzman C, Siljamaki E, Posada IM, Lacey E, Aittokallio T, Abankwa D (2016) Oncogene 35:5248–5262CrossRef

81.

Batlle E, Clevers H (2017) Nat Med 23:1124–1134CrossRef

82.

Hangauer MJ, Viswanathan VS, Ryan MJ, Bole D, Eaton JK, Matov A, Galeas J, Dhruv HD, Berens ME, Schreiber SL, McCormick F, McManus MT (2017) Nature 551:247–250ADSCrossRef

83.

Boyerinas B, Park SM, Murmann AE, Gwin K, Montag AG, Zillhardt M, Hua YJ, Lengyel E, Peter ME (2012) Int J Cancer 130:1787–1797CrossRef

84.

Abdullah LN, Chow EK (2013) Clin Transl Med 2:3CrossRef

85.

Chen K, Huang YH, Chen JL (2013) Acta Pharmacol Sin 34:732–740CrossRef

86.

Chen YC, Ingram PN, Fouladdel S, McDermott SP, Azizi E, Wicha MS, Yoon E (2016) Sci Rep 6:27301ADSCrossRef

87.

Bae S, Park J, Kim JS (2014) Bioinformatics 30:1473–1475CrossRef

Title: Identification of Small-Molecule Inhibitors of Oncogenic Lin28–Let-7 Interaction
Author: Dr. Wan Gi Byun
Publisher: Springer Nature Singapore
Book: Discovery of Small-Molecule Modulators of Protein–RNA Interactions for Treating Cancer and COVID-19
Print ISBN: 978-981-19-7813-5

Electronic ISBN: 978-981-19-7814-2

Copyright Year: 2023
DOI: https://doi.org/10.1007/978-981-19-7814-2_2