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01-09-2018 | Research Paper

Immobilization of carborane derivatives on Ni/Fe nanotubes for BNCT

Authors: Ilya V. Korolkov, Artem L. Kozlovskiy, Yevgeniy G. Gorin, Aleksander V. Kazantsev, Dmitriy I. Shlimas, Maxim V. Zdorovets, Nazerke K. Ualieva, Viacheslav S. Rusakov

Published in: Journal of Nanoparticle Research | Issue 9/2018

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Abstract

The most important limitation for boron neutron capture therapy of cancer is the selective accumulation of boron compounds in tumor tissues in significant quantities. In this paper, we describe the possibility to use magnetic Ni/Fe nanotubes as carriers for boron delivery. Carborane derivatives containing 10 and 21 boron atoms per molecule were immobilized on Ni/Fe nanotubes by covalent and ionic interactions. Magnetic properties of NTs were investigated by Mössbauer spectroscopy. Structure, element, chemical composition, and morphology of obtained magnetic nanotubes were studied by XRD, SEM-EDA, and FTIR spectroscopy. Results indicate success immobilization of carborane derivatives on Ni/Fe nanotubes and great potential to use them as carriers for boron neutron cancer therapy of cancer.

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Title: Immobilization of carborane derivatives on Ni/Fe nanotubes for BNCT
Authors: Ilya V. Korolkov
Artem L. Kozlovskiy
Yevgeniy G. Gorin
Aleksander V. Kazantsev
Dmitriy I. Shlimas
Maxim V. Zdorovets
Nazerke K. Ualieva
Viacheslav S. Rusakov
Publication date: 01-09-2018
Publisher: Springer Netherlands
Published in: Journal of Nanoparticle Research / Issue 9/2018
Print ISSN: 1388-0764
Electronic ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-018-4346-8

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