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Published in: Journal of Computational Neuroscience 3/2009

01-12-2009

Implications of gain modulation in brainstem circuits: VOR control system

Authors: Elham Khojasteh, Henrietta L. Galiana

Published in: Journal of Computational Neuroscience | Issue 3/2009

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Abstract

Gain modulation is believed to be a common integration mechanism employed by neurons to combine information from various sources. Although gain fields have been shown to exist in some cortical and subcortical areas of the brain, their existence has not been explored in the brainstem. In the present modeling study, we develop a physiologically relevant simplified model for the angular vestibulo-ocular reflex (VOR) to show that gain modulation could also be the underlying mechanism that modifies VOR function with sensorimotor context (i.e. concurrent eye positions and stimulus intensity). The resulting nonlinear model is further extended to generate both slow and quick phases of the VOR. Through simulation of the hybrid nonlinear model we show that disconjugate eye movements during the VOR are an inevitable consequence of the existence of such gain fields in the bilateral VOR pathway. Finally, we will explore the properties of the predicted disconjugate component. We will demonstrate that the apparent phase characteristics of the disconjugate response vary with the concurrent conjugate component.

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Appendix
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Metadata
Title
Implications of gain modulation in brainstem circuits: VOR control system
Authors
Elham Khojasteh
Henrietta L. Galiana
Publication date
01-12-2009
Publisher
Springer US
Published in
Journal of Computational Neuroscience / Issue 3/2009
Print ISSN: 0929-5313
Electronic ISSN: 1573-6873
DOI
https://doi.org/10.1007/s10827-009-0156-4

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