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2024 | Book

Individual-Based Models and Their Limits

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About this book

Individual-based models (IBM) describe a population as a collection of different organisms whose local interactions determine the behaviour of the entire population. The individual description is convenient for computer simulations and the determination of various model parameters, and appropriate limit passages lead to the transport equations used in classical population dynamics models. The aim of this book is to provide a brief mathematical introduction to IBMs and their application to selected biological topics. The book is divided into seven chapters. In the first chapter we give a general description of IBMs and we present examples of models to illustrate their possible applications. Examples of applications include age, size and phenotype models, coagulation-fragmentation process, and models of genome evolution. The second chapter contains some theoretical results concerning limit passages from IBMs to phenotype and age-structured models. The rate of this convergence formulated as functional central limit theorems is presented in Chapter 3. As a result of the limit passage can be a superprocess, i.e., a stochastic process with values in a space of measures. Chapter 4 presented examples of such passages: from the branching Brownian motion to the Dawson--Watanabe superprocess and from the Moran's model of genetic drift with mutations to the Fleming--Viot superprocess. The next three chapters are devoted to models, in which we directly participated in the study. In Chapter 5 we study IBMs phenotype models and their limit passages. We show that random mating stabilises the distribution of traits, while assortative mating can lead to a polymorphic population. Formation of aggregates of phytoplankton and their movement is studied in Chapter 6. We present two types of models based on: fragmentation-coagulation processes; and diffusion with chemical signals leading to advanced superprocesses. Chapter 7 is devoted to rather advanced models with chemotaxis used to description of retinal angiogenesis and cell proliferations. The book is complemented by two appendices in which we have collected information about stochastic processes and various spaces we have used. The book is dedicated both to mathematicians and biologists. The first group will find here new biological models which leads to interesting and often new mathematical questions. Biologists can observe how to include seemingly different biological processes into a unified mathematical theory and deduce from this theory interesting biological conclusions. Apart from the sections on superprocesses, where quite advanced mathematical issues arise, such as stochastic partial equations, we try to keep the required mathematical and biological background to a minimum so that the topics are accessible to students.

Table of Contents

Frontmatter
Chapter 1. Models
Abstract
Individual-based models play a special role in applications of mathematics to biological problems. They describe a population as a heterogeneous family of individuals and the relationships between them. This description is relatively simple and convenient to simulate by computer and to determine various model parameters. Moreover, a macroscopic description of the population can be obtained from an individual-based model by appropriate limits. In this chapter we give a general characterization of individual-based models and we present examples of models to illustrate their possible applications. Examples of applications include age, size and phenotype models, coagulation-fragmentation process, and models of genome evolution.
Ryszard Rudnicki, Radosław Wieczorek
Chapter 2. Limit Passages
Abstract
In this chapter we introduce the mathematical apparatus needed to maintain macroscopic models from individual models through appropriate limit passages. We restrict our investigation to pure-jump IBMs. We show that starting from such models we can obtain in limits: phenotype models with intra-species competition, McKenrick’s age-structure model, and a superprocess which is a simplified version of Dawson’s superprocess.
Ryszard Rudnicki, Radosław Wieczorek
Chapter 3. Central Limit-Type Theorems
Abstract
Chapter 2 was devoted to limit passages of sequences of individual-based models to some, usually deterministic, limit. Here we investigate the behaviour of the fluctuation processes, i.e. the difference between the converging process and the limit. We show that after appropriate rescaling the fluctuation process can converge to some Gaussian process. We use this approach to the models from the previous chapter to prove examples of CLT-type theorems.
Ryszard Rudnicki, Radosław Wieczorek
Chapter 4. Selected Superprocesses
Abstract
In this chapter we present the Dawson–Watanabe superprocess. It is the limit process for an IBM, describing cells which move according to a Brownian motion and die or divide. We introduce a stochastic partial differential equation related to this superprocess. We also present a historical superprocess and the Fleming-Viot superprocess, which combines Moran’s model of genetic drift with mutations.
Ryszard Rudnicki, Radosław Wieczorek
Chapter 5. Phenotype Models
Abstract
We present phenotypic IBMs and the limit passage from these models to a non-linear transport equation. We study two types of models: with random or assortative mating. In the case of random mating we give a theorem on asymptotic stability of the model. We show that assortative mating can lead to a polymorphic population and sympatric speciation.
Ryszard Rudnicki, Radosław Wieczorek
Chapter 6. Modelling of Phytoplankton Dynamics
Abstract
IBMs allow us to describe processes of formation of aggregates of phytoplankton and their movement. We present two types of phytoplankton IBMs: the first type is based on fragmentation-coagulation processes. In the second type of models, we consider single cells that move by diffusion and chemical signals. The limit passages in these models lead to nonlinear transport equations and advanced superprocesses.
Ryszard Rudnicki, Radosław Wieczorek
Chapter 7. Chemotaxis Models
Abstract
In some models, individuals interact via some chemical factors. Such models are described by IBMs coupled to partial differential equations. We present two models of this kind: the first—motivating, strictly biological—a model of retinal angiogenesis. And the second, conceptually simpler but preserving most mathematical features, is a model of proliferating cells that undergo chemotaxis.
Ryszard Rudnicki, Radosław Wieczorek
Backmatter
Metadata
Title
Individual-Based Models and Their Limits
Authors
Ryszard Rudnicki
Radosław Wieczorek
Copyright Year
2024
Electronic ISBN
978-3-031-75270-4
Print ISBN
978-3-031-75269-8
DOI
https://doi.org/10.1007/978-3-031-75270-4

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