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2011 | OriginalPaper | Chapter

Injectable Materials for Myocardial Tissue Engineering

Authors : Jennifer M. Singelyn, Karen L. Christman

Published in: Myocardial Tissue Engineering

Publisher: Springer Berlin Heidelberg

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Abstract

Injectable materials have gained recent focus as therapeutic alternatives to treat and prevent heart failure post-myocardial infarction. These materials offer the potential to treat the damaged region of the heart through minimally invasive catheter delivery. A variety of naturally derived and inspired materials, as well as synthetic materials have been explored as potential extracellular matrix replacement scaffolds to prevent a decline in cardiac function and/or improve cell transplant survival. Most recently, decellularized matrices have been suggested, to provide a cardiac-specific biomimetic replacement. This chapter will review the variety of materials that have been explored as injectable therapies for cardiac repair, with a particular focus on decellularized matrices. Additionally, this chapter will review the injection systems currently available, and the design criteria materials must meet for compatibility with minimally invasive catheter delivery.

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Title: Injectable Materials for Myocardial Tissue Engineering
Authors: Jennifer M. Singelyn
Karen L. Christman
Publisher: Springer Berlin Heidelberg
Book: Myocardial Tissue Engineering
Print ISBN: 978-3-642-18055-2

Electronic ISBN: 978-3-642-18056-9

Copyright Year: 2011
DOI: https://doi.org/10.1007/8415_2010_44