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2017 | Book

Innovative Diagnostics and Treatment: Nanorobotics and Stem Cells

Authors: Tomasz Jadczyk, Ewa Bryndza Tfaily, Sachin Mishra, Marek Jędrzejek, Marta Bołoz, Parasuraman Padmanabhan, Wojciech Wojakowski, Zdeněk Stárek, Sylvain Martel, Balázs Gulyás

Publisher: Springer Singapore

Book Series : SpringerBriefs in Applied Sciences and Technology

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About this book

This book focuses on nanorobotic agents and stem cells for biomedical applications.It is intended for researchers and clinicians interested in innovative diagnostic and therapeutic strategies based on nanorobots and stem cells.It presents current advances in the field of molecular machines, which could be applied to generate novel therapeutic-diagnostic systems.

Table of Contents

Frontmatter
Chapter 1. Advances Is Mesenchymal Stem Cell Application for Cardiovascular Disease Treatment
Abstract
Novel strategies are developed to optimize MSC function. Among them genetic modification is a promising solution to improve cell survival/engraftment after transplantation as well as to enhance cardioprotective function. Following genetic modification are described: Bcl-2, CREG, Hsp20, Akt, PI3K-2α, ILK, periostin, CXCR4, TNFR, Ang1, VEGF, Wnt11. HO-1, GSK-3β, IGF-1, SDF-1, GATA-4. Pharmacological optimization or preconditioned media are also investigated to overcome current limitation in stem cell therapy. Pharmacological agent pretreatment strategy covered in this chapter includes application of diazoxide, estradiol, lysophosphatidic acid, lovastatin, oxytocin, phorbol myristate acetate, tadalafil, trimetazidine. Cytokine and growth factor pretreatment discussed below includes stromal-derived factor 1 alpha, angiopoietin-1, insulin-like growth factor-1, transforming growth factor-α, bone morphogenetic protein-2, fibroblast growth factor-2 and insulin-like growth factor-1 cocktail, interleukin-1β and transforming growth factor-β combination. Moreover, application of including injectable hydrogels are presented including cell containing injectable biomaterials, acellular scaffolds with incorporated bio-agents, and co-application of cells and bio-agents
Tomasz Jadczyk, Ewa Bryndza Tfaily, Sachin Mishra, Marek Jędrzejek, Marta Bołoz, Parasuraman Padmanabhan, Wojciech Wojakowski, Zdeněk Stárek, Sylvain Martel, Balázs Gulyás
Chapter 2. Nanorobotic Agents and Their Biomedical Applications
Abstract
Application of nanorobotic agents is one of the most-promising perspective for future development and progress in medicine. Molecular machines gain significant attention with an ultimate goal to create a theranostic platform interacting with biological system and being able to perform atomic-level tasks. Such concept requires advanced technological approach i.e. design and assembly techniques, in vivo real-time navigation system, sensing methods as well as data transfer. Currently, both artificial (carbon nanotubes) and biological (DNA, proteins, bacteria) components are investigated as a building blocks of nanobots. This chapter presents advancements in nanorobotic agents biomedical application.
Tomasz Jadczyk, Ewa Bryndza Tfaily, Sachin Mishra, Marek Jędrzejek, Marta Bołoz, Parasuraman Padmanabhan, Wojciech Wojakowski, Zdeněk Stárek, Sylvain Martel, Balázs Gulyás
Metadata
Title
Innovative Diagnostics and Treatment: Nanorobotics and Stem Cells
Authors
Tomasz Jadczyk
Ewa Bryndza Tfaily
Sachin Mishra
Marek Jędrzejek
Marta Bołoz
Parasuraman Padmanabhan
Wojciech Wojakowski
Zdeněk Stárek
Sylvain Martel
Balázs Gulyás
Copyright Year
2017
Publisher
Springer Singapore
Electronic ISBN
978-981-10-4527-1
Print ISBN
978-981-10-4526-4
DOI
https://doi.org/10.1007/978-981-10-4527-1