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1987 | OriginalPaper | Chapter

Interactions Between Substance P and Nicotinic Acetylcholine Receptors in Pain Control Mechanisms in the Rat

Authors : J. Del Rio, M. E. De Felipe, M. T. Molinero

Published in: Substance P and Neurokinins

Publisher: Springer New York

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Substance P (SP), an excitatory neuropeptide, has been shown to inhibit the excitatory actions of acetylcholine at nicotinic receptors in different preparations such as the spinal Renshaw cells (1) and the adrenal chromaffin and PC12 cells (2, 3). This effect of SP is presumably due to an enhanced desensitization of the nicotinic receptor (3,4).

Metadata
Title
Interactions Between Substance P and Nicotinic Acetylcholine Receptors in Pain Control Mechanisms in the Rat
Authors
J. Del Rio
M. E. De Felipe
M. T. Molinero
Copyright Year
1987
Publisher
Springer New York
DOI
https://doi.org/10.1007/978-1-4612-4672-5_102