1987 | OriginalPaper | Chapter
Interactions Between Substance P and Nicotinic Acetylcholine Receptors in Pain Control Mechanisms in the Rat
Authors : J. Del Rio, M. E. De Felipe, M. T. Molinero
Published in: Substance P and Neurokinins
Publisher: Springer New York
Included in: Professional Book Archive
Activate our intelligent search to find suitable subject content or patents.
Select sections of text to find matching patents with Artificial Intelligence. powered by
Select sections of text to find additional relevant content using AI-assisted search. powered by
Substance P (SP), an excitatory neuropeptide, has been shown to inhibit the excitatory actions of acetylcholine at nicotinic receptors in different preparations such as the spinal Renshaw cells (1) and the adrenal chromaffin and PC12 cells (2, 3). This effect of SP is presumably due to an enhanced desensitization of the nicotinic receptor (3,4).