Skip to main content
main-content
Top

Hint

Swipe to navigate through the articles of this issue

01-01-2015 | Original Contribution | Issue 1/2015

Colloid and Polymer Science 1/2015

Interactions of Pluronic block copolymers with lipid vesicles depend on lipid phase and Pluronic aggregation state

Journal:
Colloid and Polymer Science > Issue 1/2015
Authors:
André Hädicke, Alfred Blume

Abstract

Differential scanning calorimetry (DSC) was used to systematically study the interaction of the Pluronic block copolymers with lipid vesicles. Concentration-dependent experiments were carried out to investigate the influence of different Pluronics (F127, F88, and F87) on the gel to liquid-crystalline phase transition of the lipids 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) and on the micellization of Pluronics. The incorporation of Pluronics into vesicles depends strongly on the lipid phase as well as the aggregation state of the polymer. For lipids in the liquid-crystalline state, membrane fluidity is high and incorporation of the poly-(propylene oxide) (PPO) part of single polymers is possible at high polymer concentration. Pluronic F127 with a longer PPO chain shows larger effects than the other Pluronics. Incorporation into gel-state liposomes is hindered, and self-aggregation into Pluronic micelles is favored. The peak width and the transition temperature of the micellization of the Pluronics are lowered in mixtures with lipids.

Please log in to get access to this content

To get access to this content you need the following product:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 69.000 Bücher
  • über 500 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Umwelt
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe

Testen Sie jetzt 30 Tage kostenlos.

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 50.000 Bücher
  • über 380 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Umwelt
  • Maschinenbau + Werkstoffe​​​​​​​




Testen Sie jetzt 30 Tage kostenlos.

Literature
About this article

Other articles of this Issue 1/2015

Colloid and Polymer Science 1/2015 Go to the issue

Premium Partner

    Image Credits