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Substance P and Neurokinins Read chapter Read first chapter

1987 | OriginalPaper | Chapter

Intrathecal Substance P Produces a Long-Term Inhibition of the Spinal Analgesic Effect of Noradrenaline

Authors : J. Sawynok, P. W. Nance

Published in: Substance P and Neurokinins

Publisher: Springer New York

Included in: Professional Book Archive

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The local application of noradrenaline (NA), clonidine and ST-91 to the spinal cord by intrathecal (i.t.) injection produces analgesia in a variety of test systems in a number of species (reviewed ref. 1). Alpha-2 adrenergic receptors are implicated in analgesia produced by these agents. The mechanisms by which these agents produce analgesia are not clearly defined. Electrophysiologically, there is evidence for both pre- and postsynaptic effects of NA [1].

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Metadata
Title
Intrathecal Substance P Produces a Long-Term Inhibition of the Spinal Analgesic Effect of Noradrenaline
Authors
J. Sawynok
P. W. Nance
Copyright Year
1987
Publisher
Springer New York
Book
Substance P and Neurokinins

Print ISBN: 978-1-4612-9109-1

Electronic ISBN: 978-1-4612-4672-5

Copyright Year: 1987

DOI
https://doi.org/10.1007/978-1-4612-4672-5_83