Iridium Catalysts for Hydrogen Isotope Exchange

The chapter delves into the use of iridium catalysts for hydrogen isotope exchange (HIE), a crucial process in the synthesis of isotopically labeled compounds. It covers the fundamentals of isotopic labeling, the importance of HIE in pharmaceutical research, and the development of various synthetic methods for HIE. The chapter also provides a detailed mechanistic analysis of iridium-catalyzed HIE, highlighting the role of different ligands and catalyst structures in determining the selectivity and efficiency of the reaction. Additionally, it discusses the applications of HIE in mass spectrometry and the challenges associated with labeling complex organic molecules. The chapter concludes with a summary of recent advancements in the field and the potential for future developments in iridium-catalyzed HIE.