The entrepreneurial ecosystem (EE) emerged in entrepreneurship literature in the 2000s, gained momentum in 2014, and dominated literature in 2016. EE-significant interaction between varying albeit interdependent stakeholders comprising players such as organizations and institutions facilitating the administration of resources and establishment and growth of new firms continues to be one of the hottest topics discussed in the entrepreneurship literature. EEs have been recognized as essential for achieving productive entrepreneurship in regions and, as a result, have gained the attraction of academia, policy, and practice. However, the term's conceptual, theoretical, and empirical foundations are still nascent, with many areas unclarified. There are concerns about the concept turning into a policy fad. With origins in the United States of America literature, and recent attention paid to emerging economies, Nigeria still trails far behind in the EE discourse. The study, therefore, aims at identifying and discussing salient gaps in the study of EE globally that require attention, narrowing the same to Africa, and specifically Nigeria, and proposing overarching research questions to guide Nigerian researchers in the study of EE. The study provides compelling arguments on why Nigerian literature needs to pay attention to this area of research, especially with the recent surge in entrepreneurial activities in selected regions in the Nation. The paper also identifies some key research questions based on the identified gaps in concepts, theories, empirical works, frameworks, methodology, geography, industry, and level of analysis that can help researchers get started in the study of EEs in Nigeria. The study concludes that the time is right for Nigerian scholars to jump on the bandwagon.