Kinetic Study of the Synthesis of a Fullerene Derivative Containing a Diterpene Fragment

The study focuses on the kinetics of synthesizing fullerene derivatives with a diterpene fragment using the Bingel reaction. It investigates the impact of halogen type in the functionalizing reagent, reagent ratios, and temperature on the reaction rates and product yields. High-performance liquid chromatography (HPLC) was employed to monitor these variables. The research reveals that increasing the mole ratio of reagents enhances the reaction rate and conversion to bis-adducts without affecting the yield of mono-adducts. Additionally, the study provides rate constants and activation energies for the reaction, demonstrating that the use of chloromethyl ketone results in slightly higher yields of mono-adducts compared to bromomethyl ketone. The kinetic modeling was performed using the DIPSolver and VizKim programs, with the results showing that a consecutive three-step mechanism best describes the reaction.