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2013 | OriginalPaper | Chapter

14. Liposome-Encapsulated Hemoglobin as an Artificial Oxygen Carrier: Technological Features, Manufacturing and Issues for Practical Application

Authors : Shinichi Kaneda, Takanobu Ishizuka, Hiroshi Goto, Hiroaki Kasukawa

Published in: Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics

Publisher: Springer Berlin Heidelberg

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Abstract

While the use of liposome-encapsulated hemoglobin (LEH) as artificial oxygen carriers (AOCs) has long been studied, its complicated manufacturing process and large production costs have hindered the progress in its development and, subsequently, its advancement to practical applications. However, we have been persistently developing LEH as an analogue of red blood cells (RBCs) for its use as AOCs, and to this end we have constructed a Good Manufacturing Practice (GMP) facility where LEH can be manufactured as biologics under quality assurance systems as well as establishing the manufacturing processes of LEH at this facility. We have also clarified the physicochemical properties and stability of LEH, and further confirmed the fundamental efficacy and safety of LEH as AOCs. Although the technology of LEH has already reached the stage of clinical testing, its high manufacturing costs remains an unsolved issue if LEH is to be used as a medicinal product.

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Metadata
Title
Liposome-Encapsulated Hemoglobin as an Artificial Oxygen Carrier: Technological Features, Manufacturing and Issues for Practical Application
Authors
Shinichi Kaneda
Takanobu Ishizuka
Hiroshi Goto
Hiroaki Kasukawa
Copyright Year
2013
Publisher
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-642-40717-8_14

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