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Published in: Quality of Life Research 12/2017

05-09-2017

Measurement properties of the EQ-5D-5L compared to the EQ-5D-3L in psoriasis patients

Authors: Adrienn Katalin Poór, Fanni Rencz, Valentin Brodszky, László Gulácsi, Zsuzsanna Beretzky, Bernadett Hidvégi, Péter Holló, Sarolta Kárpáti, Márta Péntek

Published in: Quality of Life Research | Issue 12/2017

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Abstract

The purpose of this study is to assess the measurement properties of EQ-5D-5L compared to EQ-5D-3L in psoriasis patients.

Methods

A cross-sectional survey was carried out at an academic dermatology clinic in Hungary. Psoriasis patients completed the EQ-5D-3L, EQ-5D-5L and Dermatology Life Quality Index (DLQI) questionnaires, and Psoriasis Area and Severity Index (PASI) was assessed. The UK value sets were used to calculate the 3L and 5L index scores. We tested the feasibility, ceiling effect, redistribution properties, the level of inconsistency and informativity (Shannon and Shannon Evenness indices). Spearman’s rank-order correlations were performed between EQ-5D, EQ VAS, DLQI and PASI scores. Known-groups validity was evaluated by comparing age groups, clinical subtypes and treatment groups.

Results

Mean age of the 238 patients was 47 years, and 36.6% of them received biological therapy. Mean EQ-5D index score was 0.77 (SD: 0.26) with the 3L and 0.84 (SD: 0.19) with the 5L. The overall ceiling effect decreased from 37.1 (3L) to 32.9% (5L). Shannon index improved significantly for most dimensions, but Shannon Evenness index improved only in three dimensions. Compared to the 3L, the 5L version confirmed a better convergent validity with PASI, but not with the DLQI. Known-groups validity was equally demonstrated both for the 5L and 3L.

Conclusions

The EQ-5D-5L seems to improve measurement properties by reducing ceiling effects, strengthening correlations with PASI and improving informativity. Follow-up studies are needed to test responsiveness and reliability in psoriasis.

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Metadata
Title
Measurement properties of the EQ-5D-5L compared to the EQ-5D-3L in psoriasis patients
Authors
Adrienn Katalin Poór
Fanni Rencz
Valentin Brodszky
László Gulácsi
Zsuzsanna Beretzky
Bernadett Hidvégi
Péter Holló
Sarolta Kárpáti
Márta Péntek
Publication date
05-09-2017
Publisher
Springer International Publishing
Published in
Quality of Life Research / Issue 12/2017
Print ISSN: 0962-9343
Electronic ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-017-1699-x

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