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Journal of Materials Science
Published in: Journal of Materials Science 11/2019

06-03-2019 | Materials for life sciences

Melt spinning of nano-hydroxyapatite and polycaprolactone composite fibers for bone scaffold application

Authors: Wen Xue, Peifeng Chen, Fujun Wang, Lu Wang

Published in: Journal of Materials Science | Issue 11/2019

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Abstract

Textile technology shows great advantages in tissue engineering applications and it is a promising candidate for bone scaffolds fabrication. Composite fibers made from nano-hydroxyapatite (nHA) particles and polycaprolactone (PCL) were prepared by the melt spinning technology. nHA particles with different concentrations (1, 3, 5 and 7 wt%) were loaded into PCL fibers, and their influence on fiber morphological, thermal, mechanical and biological performance was evaluated. Results indicated that nHA particles were homogeneously distributed in PCL fibers. And nHA loading improved the break stress and initial modulus of pure PCL fibers, as well as thermal stability, which was confirmed by thermogravimetric analysis. Mineral deposition was also observed on fibers with nHA loading, which was favorable to bone scaffolds. Tubular meshes made by weft knitting proved the manufacturability of nHA/PCL composite fibers for further scaffold applications.
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Metadata
Title
Melt spinning of nano-hydroxyapatite and polycaprolactone composite fibers for bone scaffold application
Authors
Wen Xue
Peifeng Chen
Fujun Wang
Lu Wang
Publication date
06-03-2019
Publisher
Springer US
Published in
Journal of Materials Science / Issue 11/2019
Print ISSN: 0022-2461
Electronic ISSN: 1573-4803
DOI
https://doi.org/10.1007/s10853-019-03475-y

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