1987 | OriginalPaper | Chapter
Miotic Effect of Echothiophate Iodide in Humans: Possible Role of Iris Substance P
Authors : M. Fanciullacci, M. Nicolodi, U. Pietrini, P. Geppetti, S. Rizzo, F. Sicuteri
Published in: Substance P and Neurokinins
Publisher: Springer New York
Included in: Professional Book Archive
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In man trigeminal stimulation produces constriction of the pupil: this pupillary effect can be attributed to substance P (SP) release from trigeminal sensory nerve fibers [1]. In fact SP-1ike immunoreactive nerve fibers have been visualized in iris sphincter muscle [2]. This discovery has opened question about the pathophysiological role of SP in the human iris. Our radioimmunological and pupillopharmacological data have been carried out to clarify this problem.