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International Journal of Computer Assisted Radiology and Surgery

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01-03-2015 | Original Article

Multi-contrast unbiased MRI atlas of a Parkinson’s disease population

Authors: Yiming Xiao, Vladimir Fonov, Silvain Bériault, Fahd Al Subaie, M. Mallar Chakravarty, Abbas F. Sadikot, G. Bruce Pike, D. Louis Collins

Published in: International Journal of Computer Assisted Radiology and Surgery | Issue 3/2015

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Abstract

Purpose

Parkinson’s disease (PD) is the second leading neurodegenerative disease after Alzheimer’s disease. In PD research and its surgical treatment, such as deep brain stimulation (DBS), anatomical structural identification and references for spatial normalization are essential, and human brain atlases/templates are proven highly instrumental. However, two shortcomings affect current templates used for PD. First, many templates are derived from a single healthy subject that is not sufficiently representative of the PD-population anatomy. This may result in suboptimal surgical plans for DBS surgery and biased analysis for morphological studies. Second, commonly used mono-contrast templates lack sufficient image contrast for some subcortical structures (i.e., subthalamic nucleus) and biochemical information (i.e., iron content), a valuable feature in current PD research.

Methods

We employed a novel T1–T2* fusion MRI that visualizes both cortical and subcortical structures to drive groupwise registration to create co-registered multi-contrast (T1w, T2*w, T1–T2* fusion, phase, and an R2* map) unbiased templates from 15 PD patients, and a high-resolution histology-derived 3D atlas is co-registered. For validation, these templates are compared against the Colin27 template for landmark registration and midbrain nuclei segmentation.

Results

While the T1w, T2*w, and T1–T2* fusion templates provide excellent anatomical details for both cortical and subcortical structures, the phase and R2* map contain the biochemical features. By one-way ANOVA tests, our templates significantly (\(p<0.05\)) outperform the Colin27 template in the registration-based tasks.

Conclusion

The proposed unbiased templates are more representative of the population of interest and can benefit both the surgical planning and research of PD.

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Title: Multi-contrast unbiased MRI atlas of a Parkinson’s disease population
Authors: Yiming Xiao
Vladimir Fonov
Silvain Bériault
Fahd Al Subaie
M. Mallar Chakravarty
Abbas F. Sadikot
G. Bruce Pike
D. Louis Collins
Publication date: 01-03-2015
Publisher: Springer Berlin Heidelberg
Published in: International Journal of Computer Assisted Radiology and Surgery / Issue 3/2015
Print ISSN: 1861-6410
Electronic ISSN: 1861-6429
DOI: https://doi.org/10.1007/s11548-014-1068-y

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Abstract

Purpose

Methods

Results

Conclusion

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